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01-10-2013 | Educational Review

Is obesity a risk factor for chronic kidney disease in children?

Authors: Sujana S. Gunta, Robert H. Mak

Published in: Pediatric Nephrology | Issue 10/2013

Abstract

There is a rapid increase worldwide in the prevalence of obesity in adults and children. Obesity is not only a comorbidity for chronic kidney disease (CKD) but may also be a risk factor for CKD. Epidemiological correlations and pathophysiological changes have been observed associating obesity with CKD. Low birth weight may be associated with both obesity and low nephron mass, leading to CKD later in life. Elevated levels of adipokines, such as leptin and adiponectin, in obesity may be factors in CKD pathogenesis and progression. Furthermore, various other factors, such as hypertension, increased cardiovascular morbidity, insulin resistance, dyslipidemia, and lipotoxicity, may play significant roles in the pathogenesis of CKD in obesity. Reduction in obesity, which is a potentially modifiable risk factor, might help decrease the burden of CKD in the population. Apart from individualized options, community-based interventions have the potential to create a strong impact in this condition.

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Title: Is obesity a risk factor for chronic kidney disease in children?
Authors: Sujana S. Gunta
Robert H. Mak
Publication date: 01-10-2013
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 10/2013
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2353-z

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