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19-05-2023 | Strabismus | Review

Epigenetic modifications and obsessive–compulsive disorder: what do we know?

Authors: Amir Hossein Mohammadi, Mohammad Karimian, Hamed Mirzaei, Alireza Milajerdi

Published in: Brain Structure and Function | Issue 5/2023

Abstract

Obsessive–Compulsive Disorder (OCD) is a chronic, severe disabling neuropsychiatric disorder whose pathophysiology is not yet well defined. Generally, the symptom onset occurs during pre-adult life and affects subjects in different life aspects, including professional and social relationships. Although robust evidence indicates the presence of genetic factors in the etiopathology of OCD, the entirely mechanisms are not totally clarified. Thus, the possible interactions between genes and environmental risk factors mediated by epigenetic mechanisms should be sought. Therefore, we provide a review of genetic and epigenetic mechanisms related to OCD with a deep focus on the regulation of critical genes of the central nervous system seeking possible potential biomarkers.

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Title: Epigenetic modifications and obsessive–compulsive disorder: what do we know?
Authors: Amir Hossein Mohammadi
Mohammad Karimian
Hamed Mirzaei
Alireza Milajerdi
Publication date: 19-05-2023
Publisher: Springer Berlin Heidelberg
Keywords: Strabismus
Strabismus
Obsessive-Compulsive Disorder
Epigenetics
Published in: Brain Structure and Function / Issue 5/2023
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-023-02649-4

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Epigenetic modifications and obsessive–compulsive disorder: what do we know?

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