Published in:
01-04-2018 | Invited Editorial
Pulmonary neuroendocrine carcinomas—evidence for a spectrum of differentiation
Author:
Annikka Weissferdt
Published in:
Virchows Archiv
|
Issue 4/2018
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Excerpt
In this issue, Pelosi and colleagues present the results of a gene alteration analysis of a large series of pulmonary neuroendocrine carcinomas. This study provides molecular support for the concept that carcinoid tumors can transform into high-grade neuroendocrine carcinomas through the acquisition of additional molecular alterations. This concept challenges the current and widely held belief that carcinoid tumors are different histogenetic entities from the high-grade neuroendocrine carcinomas thereby denying the existence of any transitional forms. …