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Published in: Langenbeck's Archives of Surgery 6/2014

01-08-2014 | Original Article

Morbidity of central neck dissection: primary surgery vs reoperation. Results of a case–control study

Authors: Celestino Pio Lombardi, Marco Raffaelli, Carmela De Crea, Luca Sessa, Rocco Bellantone

Published in: Langenbeck's Archives of Surgery | Issue 6/2014

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Abstract

Purpose

Complication rate in reoperative central neck node surgery is one of the main arguments to favor prophylactic central neck dissection at first operation in patients with papillary thyroid carcinoma. We evaluated if reoperative central neck dissection implies an increased postoperative morbidity. Secondarily, we aimed also to verify the effectiveness of the surgical resection of reoperative central neck dissection.

Methods

Forty-one patients who underwent reoperative central neck dissection after initial thyroidectomy for papillary thyroid carcinoma between January 2008 and May 2012 were compared to 41 controls who underwent central neck dissection at initial operation.

Results

The two groups were well matched for age, sex, and pN stage (P = 0.296, 0.199, and 1.000, respectively). Three patients had distant metastases at presentation. No significant difference was found concerning mean number of removed nodes (P = 0.064). No significant difference was found between the reoperative and the control groups concerning transient hypocalcemia (17 vs 19, respectively) (P = 0.901) and transient recurrent nerve palsy (2 vs 2) (P = 0.608). Follow-up was completed in 69 out of all the included patients (85.2 %). At a mean follow-up of 33 months, two patients (2.9 %) experienced nodal recurrence.

Conclusions

Morbidity of central neck dissection is similar for primary surgery and reoperation. In high-volume centers, reoperative central neck dissection can be safely accomplished when needed, allowing to achieve locoregional control in most of patients.
Literature
1.
go back to reference Shan CX, Zhang W, Jiang DZ, Zheng XM, Liu S, Qui M (2011) Routine central neck dissection in differentiated thyroid carcinoma: a systematic review and meta-analysis. Laryngoscope 122:797–804CrossRef Shan CX, Zhang W, Jiang DZ, Zheng XM, Liu S, Qui M (2011) Routine central neck dissection in differentiated thyroid carcinoma: a systematic review and meta-analysis. Laryngoscope 122:797–804CrossRef
2.
go back to reference Sippel RS, Chen H (2009) Controversies in the surgical management of newly diagnosed and recurrent/residual thyroid cancer. Thyroid 19:1373–1380PubMedCrossRef Sippel RS, Chen H (2009) Controversies in the surgical management of newly diagnosed and recurrent/residual thyroid cancer. Thyroid 19:1373–1380PubMedCrossRef
3.
go back to reference Shaha AR (2009) Prophylactic central compartment dissection in thyroid cancer: a new avenue of debate. Surgery 146:1224–1227PubMedCrossRef Shaha AR (2009) Prophylactic central compartment dissection in thyroid cancer: a new avenue of debate. Surgery 146:1224–1227PubMedCrossRef
4.
go back to reference Carling T, Long WD III, Udelsman R (2010) Controversy surrounding the role for routine central lymph node dissection for differentiated thyroid cancer. Curr Opin Oncol 22:30–34PubMedCrossRef Carling T, Long WD III, Udelsman R (2010) Controversy surrounding the role for routine central lymph node dissection for differentiated thyroid cancer. Curr Opin Oncol 22:30–34PubMedCrossRef
5.
go back to reference McHenry CR (2011) Prophylactic central compartment neck dissection for papillary thyroid cancer: the search for justification continues. Surgery 150:1058–1060PubMedCrossRef McHenry CR (2011) Prophylactic central compartment neck dissection for papillary thyroid cancer: the search for justification continues. Surgery 150:1058–1060PubMedCrossRef
6.
go back to reference Hay ID, Thompson GB, Grant CS, Bergstralh EJ, Dvorak CE, Gorman CA, Maurer MS, McIver B, Mullan BP, Oberg AL, Powell CC, van Heerden JA, Goellner JR (2002) Papillary thyroid carcinoma managed at the Mayo Clinic during six decades (1940–1999): temporal trends in initial therapy and long-term outcome in 2444 consecutively treated patients. World J Surg 26:879–885PubMedCrossRef Hay ID, Thompson GB, Grant CS, Bergstralh EJ, Dvorak CE, Gorman CA, Maurer MS, McIver B, Mullan BP, Oberg AL, Powell CC, van Heerden JA, Goellner JR (2002) Papillary thyroid carcinoma managed at the Mayo Clinic during six decades (1940–1999): temporal trends in initial therapy and long-term outcome in 2444 consecutively treated patients. World J Surg 26:879–885PubMedCrossRef
7.
go back to reference Hughes DT, Laird AM, Miller BS, Gauger PG, Doherty GM (2012) Reoperative lymph node dissection for recurrent papillary thyroid cancer and effect on serum thyroglobulin. Ann Surg Oncol 19:2951–2957PubMedCrossRef Hughes DT, Laird AM, Miller BS, Gauger PG, Doherty GM (2012) Reoperative lymph node dissection for recurrent papillary thyroid cancer and effect on serum thyroglobulin. Ann Surg Oncol 19:2951–2957PubMedCrossRef
8.
go back to reference American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19:1167–1214PubMedCrossRef American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19:1167–1214PubMedCrossRef
9.
go back to reference Simon D, Goretzki PE, Witte J, Röher HD (1996) Incidence of regional recurrence guiding radicality in differentiated thyroid carcinoma. World J Surg 20:860–866PubMedCrossRef Simon D, Goretzki PE, Witte J, Röher HD (1996) Incidence of regional recurrence guiding radicality in differentiated thyroid carcinoma. World J Surg 20:860–866PubMedCrossRef
10.
go back to reference Segal K, Friedental R, Lubin E, Shvero J, Sulkes J, Feinmesser R (1995) Papillary carcinoma of the thyroid. Otolaryngol Head Neck Surg 113:356–363PubMedCrossRef Segal K, Friedental R, Lubin E, Shvero J, Sulkes J, Feinmesser R (1995) Papillary carcinoma of the thyroid. Otolaryngol Head Neck Surg 113:356–363PubMedCrossRef
11.
go back to reference Moley JF, Lairmore TC, Doherty GM, Brunt LM, DeBenedetti MK (1999) Preservation of the recurrent laryngeal nerves in thyroid and parathyroid reoperations. Surgery 126:673–679PubMedCrossRef Moley JF, Lairmore TC, Doherty GM, Brunt LM, DeBenedetti MK (1999) Preservation of the recurrent laryngeal nerves in thyroid and parathyroid reoperations. Surgery 126:673–679PubMedCrossRef
12.
go back to reference Uruno T, Miyauchi A, Shimizu K, Nakano K, Takamura Y, Ito Y, Miya A, Kobayashi K, Yokozawa T, Matsuzuka F, Kuma K (2004) Prognosis after reoperation for local recurrence of papillary thyroid carcinoma. Surg Today 34:891–895PubMedCrossRef Uruno T, Miyauchi A, Shimizu K, Nakano K, Takamura Y, Ito Y, Miya A, Kobayashi K, Yokozawa T, Matsuzuka F, Kuma K (2004) Prognosis after reoperation for local recurrence of papillary thyroid carcinoma. Surg Today 34:891–895PubMedCrossRef
13.
go back to reference Ondik MP, Dezfoli S, Lipinski L, Ruggiero F, Goldenberg D (2009) Secondary central compartment surgery for thyroid cancer. Laryngoscope 119:1947–1950PubMedCrossRef Ondik MP, Dezfoli S, Lipinski L, Ruggiero F, Goldenberg D (2009) Secondary central compartment surgery for thyroid cancer. Laryngoscope 119:1947–1950PubMedCrossRef
14.
go back to reference Kim MK, Mandel SH, Baloch Z, LiVolsi VA, Langer JE, DiDonato L, Fish S, Weber RS (2004) Morbidity following central compartment reoperation for recurrent or persistent thyroid cancer. Arch Otolaryngol Head Neck Surg 130:1214–1216PubMedCrossRef Kim MK, Mandel SH, Baloch Z, LiVolsi VA, Langer JE, DiDonato L, Fish S, Weber RS (2004) Morbidity following central compartment reoperation for recurrent or persistent thyroid cancer. Arch Otolaryngol Head Neck Surg 130:1214–1216PubMedCrossRef
15.
go back to reference Alvarado R, Sywak MS, Delbridge L, Sidhu SB (2009) Central lymph node dissection as a secondary procedure for papillary thyroid cancer: is there added morbidity? Surgery 145:514–518PubMedCrossRef Alvarado R, Sywak MS, Delbridge L, Sidhu SB (2009) Central lymph node dissection as a secondary procedure for papillary thyroid cancer: is there added morbidity? Surgery 145:514–518PubMedCrossRef
16.
go back to reference Shen WT, Ogawa L, Ruan D, Suh I, Kebebew E, Duh QY, Clark OH (2010) Central neck lymph node dissection for papillary thyroid cancer: comparison of complication and recurrence rates in 295 initial dissections and reoperations. Arch Surg 145:272–275PubMedCrossRef Shen WT, Ogawa L, Ruan D, Suh I, Kebebew E, Duh QY, Clark OH (2010) Central neck lymph node dissection for papillary thyroid cancer: comparison of complication and recurrence rates in 295 initial dissections and reoperations. Arch Surg 145:272–275PubMedCrossRef
17.
go back to reference White ML, Gauger PG, Doherty GM (2007) Central lymph node dissection in differentiated thyroid cancer. World J Surg 31:895–904PubMedCrossRef White ML, Gauger PG, Doherty GM (2007) Central lymph node dissection in differentiated thyroid cancer. World J Surg 31:895–904PubMedCrossRef
18.
go back to reference Al-Saif O, Farrar WB, Bloomston M, Porter K, Ringel MD, Kloos RT (2010) Long-term efficacy of lymph node reoperation for persistent papillary thyroid cancer. J Clin Endocrinol Metab 95:2187–2194PubMedCrossRef Al-Saif O, Farrar WB, Bloomston M, Porter K, Ringel MD, Kloos RT (2010) Long-term efficacy of lymph node reoperation for persistent papillary thyroid cancer. J Clin Endocrinol Metab 95:2187–2194PubMedCrossRef
19.
go back to reference Schuff KG, Weber SM, Givi B, Samuels MH, Andersen PE, Cohen JI (2008) Efficacy of nodal dissection for treatment of persistent/recurrent papillary thyroid cancer. Laryngoscope 118:768–775PubMedCrossRef Schuff KG, Weber SM, Givi B, Samuels MH, Andersen PE, Cohen JI (2008) Efficacy of nodal dissection for treatment of persistent/recurrent papillary thyroid cancer. Laryngoscope 118:768–775PubMedCrossRef
20.
go back to reference Yim JH, Kim WB, Kim EY, Kim TY, Ryu JS, Gong G, Hong SJ, Shong YK (2011) The outcomes of first reoperation for locoregionally recurrent/persistent papillary thyroid carcinoma in patients who initially underwent total thyroidectomy and remnant ablation. J Clin Endocrinol Metab 96:2049–2056PubMedCrossRef Yim JH, Kim WB, Kim EY, Kim TY, Ryu JS, Gong G, Hong SJ, Shong YK (2011) The outcomes of first reoperation for locoregionally recurrent/persistent papillary thyroid carcinoma in patients who initially underwent total thyroidectomy and remnant ablation. J Clin Endocrinol Metab 96:2049–2056PubMedCrossRef
21.
go back to reference Tufano RP, Bishop J, Wu G (2012) Reoperative central compartment dissection for patients with recurrent/persistent papillary thyroid cancer: efficacy, safety, and the association of the BRAF mutation. Laryngoscope 122:1634–1640PubMedCrossRef Tufano RP, Bishop J, Wu G (2012) Reoperative central compartment dissection for patients with recurrent/persistent papillary thyroid cancer: efficacy, safety, and the association of the BRAF mutation. Laryngoscope 122:1634–1640PubMedCrossRef
22.
go back to reference American Thyroid Association Surgery Working Group; American Association of Endocrine Surgeons, American Accademy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society, Carty SE, Cooper DS, Doherty GM, Duh QY, Kloos RT, Mandel SJ, Randolph GW, Stack BC Jr, Steward DL, Terris DJ, Thompson GB, Tufano RP, Tuttle RM, Udelsman R (2009) Consensus statement on the terminology and classification of central neck dissection for thyroid cancer. Thyroid 19:1153–1158PubMedCrossRef American Thyroid Association Surgery Working Group; American Association of Endocrine Surgeons, American Accademy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society, Carty SE, Cooper DS, Doherty GM, Duh QY, Kloos RT, Mandel SJ, Randolph GW, Stack BC Jr, Steward DL, Terris DJ, Thompson GB, Tufano RP, Tuttle RM, Udelsman R (2009) Consensus statement on the terminology and classification of central neck dissection for thyroid cancer. Thyroid 19:1153–1158PubMedCrossRef
23.
go back to reference Stack BC, Ferris RL, Goldenberg D, Haymart M, Shaha A, Sheth S, Sosa JA, Tufano RP, for the American Thyroid Association Surgical Affairs Committee (2012) American Thyroid Association consensus review and statement regarding the anatomy, terminology, and rationale for lateral neck dissection in differentiated thyroid cancer. Thyroid 22:501–508PubMedCrossRef Stack BC, Ferris RL, Goldenberg D, Haymart M, Shaha A, Sheth S, Sosa JA, Tufano RP, for the American Thyroid Association Surgical Affairs Committee (2012) American Thyroid Association consensus review and statement regarding the anatomy, terminology, and rationale for lateral neck dissection in differentiated thyroid cancer. Thyroid 22:501–508PubMedCrossRef
24.
go back to reference American Joint Committee on Cancer (2010) Thyroid. AJCC Cancer Staging Manual, 7th edn. Springer, New York, pp 87–92CrossRef American Joint Committee on Cancer (2010) Thyroid. AJCC Cancer Staging Manual, 7th edn. Springer, New York, pp 87–92CrossRef
25.
go back to reference Raffaelli M, De Crea C, Carrozza C, D’Amato G, Zuppi C, Bellantone R, Lombardi CP (2012) Combining early postoperative parathyroid hormone and serum calcium levels allows for an efficacious selective post thyroidectomy supplementation treatment. World J Surg 36:1307–1313PubMedCrossRef Raffaelli M, De Crea C, Carrozza C, D’Amato G, Zuppi C, Bellantone R, Lombardi CP (2012) Combining early postoperative parathyroid hormone and serum calcium levels allows for an efficacious selective post thyroidectomy supplementation treatment. World J Surg 36:1307–1313PubMedCrossRef
26.
go back to reference Lombardi CP, Raffaelli M, De Crea C, Princi P, Castaldi P, Spaventa A, Salvatori M, Bellantone R (2007) Report on 8 years of experience with video assisted thyroidectomy for papillary thyroid carcinoma. Surgery 142:944–951PubMedCrossRef Lombardi CP, Raffaelli M, De Crea C, Princi P, Castaldi P, Spaventa A, Salvatori M, Bellantone R (2007) Report on 8 years of experience with video assisted thyroidectomy for papillary thyroid carcinoma. Surgery 142:944–951PubMedCrossRef
27.
go back to reference Salvatori M, Raffaelli M, Castaldi P, Treglia G, Rufini V, Perotti G, Lombardi CP, Rubello D, Ardito G, Bellantone R (2007) Evaluation of the surgical completeness after total thyroidectomy for differentiated thyroid carcinoma. Eur J Surg Oncol 33:648–654PubMedCrossRef Salvatori M, Raffaelli M, Castaldi P, Treglia G, Rufini V, Perotti G, Lombardi CP, Rubello D, Ardito G, Bellantone R (2007) Evaluation of the surgical completeness after total thyroidectomy for differentiated thyroid carcinoma. Eur J Surg Oncol 33:648–654PubMedCrossRef
28.
go back to reference Lombardi CP, Bellantone R, De Crea C, Paladino NC, Fadda G, Salvatori M, Raffaelli M (2010) Papillary thyroid microcarcinoma: extrathyroidal extension, lymph node metastases, and risk factors for recurrence in a high prevalence of goiter area. World J Surg 34:1214–1221PubMedCrossRef Lombardi CP, Bellantone R, De Crea C, Paladino NC, Fadda G, Salvatori M, Raffaelli M (2010) Papillary thyroid microcarcinoma: extrathyroidal extension, lymph node metastases, and risk factors for recurrence in a high prevalence of goiter area. World J Surg 34:1214–1221PubMedCrossRef
29.
go back to reference Lombardi CP, Raffaelli M, De Crea C, Sessa L, Rampulla V, Bellantone R (2012) Video-assisted versus conventional total thyroidectomy and central compartment neck dissection for papillary thyroid carcinoma. World J Surg 36:1225–1230PubMedCrossRef Lombardi CP, Raffaelli M, De Crea C, Sessa L, Rampulla V, Bellantone R (2012) Video-assisted versus conventional total thyroidectomy and central compartment neck dissection for papillary thyroid carcinoma. World J Surg 36:1225–1230PubMedCrossRef
30.
go back to reference Raffaelli M, De Crea C, Sessa L, Giustacchini P, Revelli L, Bellantone C, Lombardi CP (2012) Prospective evaluation of total thyroidectomy versus ipsilateral versus bilateral central neck dissection in patients with clinically node negative papillary thyroid carcinoma. Surgery 152:957–964PubMedCrossRef Raffaelli M, De Crea C, Sessa L, Giustacchini P, Revelli L, Bellantone C, Lombardi CP (2012) Prospective evaluation of total thyroidectomy versus ipsilateral versus bilateral central neck dissection in patients with clinically node negative papillary thyroid carcinoma. Surgery 152:957–964PubMedCrossRef
31.
go back to reference Torlontano M, Crocetti U, Augello G, D’Aloiso L, Bonfitto N, Varraso A, Dicembrino F, Modoni S, Frusciante V, DiGiorgio A, Bruno R, Filetti S, Trischitta V (2006) Comparative evaluation of recombinant human thyrotropin-stimulated thyroglobulin levels, 131I whole-body scintigraphy, and neck ultrasonography in the follow-up of patients with papillary thyroid microcarcinoma who have not undergone radioiodine therapy. J Clin Endocrinol Metab 91:60–63PubMedCrossRef Torlontano M, Crocetti U, Augello G, D’Aloiso L, Bonfitto N, Varraso A, Dicembrino F, Modoni S, Frusciante V, DiGiorgio A, Bruno R, Filetti S, Trischitta V (2006) Comparative evaluation of recombinant human thyrotropin-stimulated thyroglobulin levels, 131I whole-body scintigraphy, and neck ultrasonography in the follow-up of patients with papillary thyroid microcarcinoma who have not undergone radioiodine therapy. J Clin Endocrinol Metab 91:60–63PubMedCrossRef
32.
33.
go back to reference Dralle H, Sekulla C, Lorenz K, Brauckhoff M, Machens A, German IONM Study Group (2008) Intraoperative monitoring of the recurrent laryngeal nerve in thyroid surgery. World J Surg 32:1358–1366PubMedCrossRef Dralle H, Sekulla C, Lorenz K, Brauckhoff M, Machens A, German IONM Study Group (2008) Intraoperative monitoring of the recurrent laryngeal nerve in thyroid surgery. World J Surg 32:1358–1366PubMedCrossRef
34.
go back to reference Agarwal A, Mishra AK, Lombardi CP, Raffaelli M (2012) Applied embryology of the thyroid and parathyroid glands. In: Randolph GW (ed) Surgery of the thyroid and parathyroid glands, 2nd edn. Elsevier Saunders, Philadelphia, pp 15–24 Agarwal A, Mishra AK, Lombardi CP, Raffaelli M (2012) Applied embryology of the thyroid and parathyroid glands. In: Randolph GW (ed) Surgery of the thyroid and parathyroid glands, 2nd edn. Elsevier Saunders, Philadelphia, pp 15–24
35.
go back to reference Raffaelli M, De Crea C, Sessa L, Giustacchini P, Bellantone R, Lombardi CP (2013) Can intraoperative frozen section influence the extension of central neck dissection in cN0 papillary thyroid carcinoma? Langenbecks Arch Surg 398:383–388PubMedCrossRef Raffaelli M, De Crea C, Sessa L, Giustacchini P, Bellantone R, Lombardi CP (2013) Can intraoperative frozen section influence the extension of central neck dissection in cN0 papillary thyroid carcinoma? Langenbecks Arch Surg 398:383–388PubMedCrossRef
Metadata
Title
Morbidity of central neck dissection: primary surgery vs reoperation. Results of a case–control study
Authors
Celestino Pio Lombardi
Marco Raffaelli
Carmela De Crea
Luca Sessa
Rocco Bellantone
Publication date
01-08-2014
Publisher
Springer Berlin Heidelberg
Published in
Langenbeck's Archives of Surgery / Issue 6/2014
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-014-1201-y

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