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01-03-2009 | Original Article

Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives

Authors: R. V. Vince, L. R. McNaughton, L. Taylor, A. W. Midgley, G. Laden, L. A. Madden

Published in: European Journal of Applied Physiology | Issue 4/2009

Abstract

Microparticles (MP) are shed into the circulation from endothelium following activation or apoptosis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positive microparticles (VCAM + MP) following simulated SCUBA dives, breathing either air or oxygen. VCAM + MP were quantified pre-dive (09:00 and 13:00) and post-dive (+1, +3 and +15 h) on both air and oxygen dives and compared with control samples taken from the same subjects. VCAM + MP followed a similar trend in all experiments, however both dives caused a change in endothelial state, as measured by VCAM + MP. A significant increase in VCAM + MP was observed 1 h post-air dive relative to the control (p = 0.013), which was not observed after the oxygen dive (p = 0.095). Oxidative stress (TBARS) was correlated with VCAM + MP. Data presented highlights the potential of MP as a biological marker of both endothelial state and decompression illness.

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Title: Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives
Authors: R. V. Vince
L. R. McNaughton
L. Taylor
A. W. Midgley
G. Laden
L. A. Madden
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 4/2009
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-008-0927-z

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Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives

Abstract

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Abstract

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