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International Archives of Occupational and Environmental Health

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22-12-2022 | Original Article

High-density lipoprotein cholesterol modifies the association between blood lead and uric acid: results from NHANES 2005–2016

Authors: Xiaoting Zou, Zifan Zhao, Weichao Huang, Yue Chen, Wanlin Zhang, Jing Luo, Tianyi Zhao, Luying Wu, Xiaoman Ma, Xuguang Guo

Published in: International Archives of Occupational and Environmental Health | Issue 4/2023

Abstract

Background

The association between blood lead (PbB) and uric acid (SUA) remains unclear in US adults without a high level of lead exposure. Additionally, the effects of high-density lipoprotein cholesterol (HDL-C) modifying this association are still unclear. Therefore, this study aims to assess the effect of modification of high-density lipoprotein cholesterol on the association between PbB and SUA.

Method

This research analyzed National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2016. Through several screenings, 18,578 participants over the age of 20 were eligible for the analysis. Multivariable linear regression was used to evaluate the association between PbB and SUA. By having stratified participants based on the HDL-C intake category (low HDL-C intake < 50 mg/dl; high HDL-C intake ≥ 50 mg/dl), effect modification by HDL-C was assessed through a likelihood ratio test between PbB and SUA.

Result

Multivariable linear regression indicated that PbB positively affects SUA (β = 0.19, 95% CI 0.16–0.22). The relationship between PbB and SUA was different in the low and high HDL-C intake group (β 0.12 95% Cl 0.08–0.16 vs. β 0.26 95% Cl 0.22 ~ − 0.30). Furthermore, high-density lipoprotein cholesterol significantly modified the relationship between PbB and SUA in all models which indicates that the interaction of lead exposure and HDL-C is more dangerous than the sum of the individual effects.

Conclusions

Our study shows that high-density lipoprotein cholesterol and blood lead have an interactive effect on increasing uric acid, which may have great importance for clinical medication.

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Title: High-density lipoprotein cholesterol modifies the association between blood lead and uric acid: results from NHANES 2005–2016
Authors: Xiaoting Zou
Zifan Zhao
Weichao Huang
Yue Chen
Wanlin Zhang
Jing Luo
Tianyi Zhao
Luying Wu
Xiaoman Ma
Xuguang Guo
Publication date: 22-12-2022
Publisher: Springer Berlin Heidelberg
Published in: International Archives of Occupational and Environmental Health / Issue 4/2023
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-022-01944-7

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Springer Medicine

High-density lipoprotein cholesterol modifies the association between blood lead and uric acid: results from NHANES 2005–2016

Abstract

Background

Method

Result

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Result

Conclusions

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