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Graefe's Archive for Clinical and Experimental Ophthalmology

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Open Access 01-09-2020 | Edema | Retinal Disorders

The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema

Authors: Ryosuke Fujino, Ryo Asaoka, Shuichiro Aoki, Aya Sugiura, Mari Kusakabe, Kimiko Asano-Shimizu, Yoko Nomura, Aya Aoki, Yohei Hashimoto, Keiko Azuma, Tatsuya Inoue, Ryo Obata

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 9/2020

Abstract

Purpose

To evaluate the usefulness of the retinal sensitivity in branch retinal vein occlusion (BVO) with macular edema (ME) following the anti-vascular endothelial growth factor (anti-VEGF) treatment.

Methods

Best-corrected visual acuity (BCVA), microperimetry, and optical coherence tomography (OCT) measurements were carried out in 20 patients with BVO with ME, at baseline and 1 month after the anti-VEGF treatment. The relationships among BCVA, mean retinal sensitivity (MS), macular volume (MV), central retinal thickness (CRT), integrity of ellipsoid zone (EZ), mean retinal sensitivity in the most affected quadrant (qMS), and macular volume in the most affected quadrant (qMV) were investigated. In addition, the relationships among the change in BCVA at 1 month (ΔBCVA1m), mean sensitivity in the most affected quadrant at 1 month (ΔqMS1m), MV in the most affected quadrant at 1 month (ΔqMV1m), and CRT at 1 month (ΔCRT1m) were analyzed. The optimal model for BCVA at 3 months after the treatment (BCVA3m) was identified.

Results

There was not a significant difference in BCVA (paired Wilcoxon test, p = 0.058) between at baseline and after the treatment, but there were significant differences in MS, MV, CRT, qMS, and qMV (p < 0.05). There was a significant relationship between ΔqMS1m and ΔMV1m, ΔCRT1m, and ΔqMV1m, respectively. ΔMS1m or ΔqMS1m and BCVA at baseline and ΔBCVA1m were selected as explanatory variables in the optimal model for BCVA3m.

Conclusion

Retinal sensitivity was related to retinal structure, whereas this was not the case with BCVA. In addition, retinal sensitivity was useful to predict BCVA after anti-VEGF therapy.

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Title: The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema
Authors: Ryosuke Fujino
Ryo Asaoka
Shuichiro Aoki
Aya Sugiura
Mari Kusakabe
Kimiko Asano-Shimizu
Yoko Nomura
Aya Aoki
Yohei Hashimoto
Keiko Azuma
Tatsuya Inoue
Ryo Obata
Publication date: 01-09-2020
Publisher: Springer Berlin Heidelberg
Keyword: Edema
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 9/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04759-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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