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Graefe's Archive for Clinical and Experimental Ophthalmology

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Open Access 01-07-2019 | Angiography | Retinal Disorders

Patient characteristics of untreated chronic central serous chorioretinopathy patients with focal versus diffuse leakage

Authors: Thomas J. van Rijssen, Elon H. C. van Dijk, Paula Scholz, Myrte B. Breukink, Rocio Blanco-Garavito, Eric H. Souied, Robert E. MacLaren, Giuseppe Querques, Sascha Fauser, Carel B. Hoyng, Susan M. Downes, Camiel J. F. Boon

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2019

Abstract

Purpose

To describe the characteristics and potential differences between focal and diffuse phenotypes of untreated chronic central serous chorioretinopathy (cCSC).

Methods

For this study, patients were divided in two groups. Focal leakage was defined as 1 “hot spot” of leakage, whereas diffuse leakage was defined as either > 1 hot spot or a larger area of widespread leakage on FA. Clinical characteristics were assessed at presentation. After Bonferroni correction, P values < 0.00125 were deemed statistically significant.

Results

The focal leakage group included 68 eyes (53 males), and the diffuse leakage group included 105 eyes (88 males). Mean best-corrected visual acuity (BCVA) was 77.1 ± 8.1 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the focal group and 76.0 ± 9.6 ETDRS letters in the diffuse group (p = 0.440). In the focal group, mean age was 46.9 ± 8.8 years, whereas this was 49.7 ± 8.3 years in the diffuse group (p = 0.033). Mean central foveal thickness was 107.1 ± 21.3 μm in the focal group and 106.2 ± 27.3 μm in the diffuse group (p = 0.818). Mean choroidal thickness was 407.5 ± 114.8 μm in the focal group and 419.1 ± 113.9 μm in the diffuse group (p = 0.578). In the focal group, subretinal fluid was present in the fellow eye in 16% of the patients, as compared to 29% in the diffuse group (p = 0.067).

Conclusions

In untreated cCSC patients with focal or diffuse leakage on FA, no marked differences in clinical characteristics were found. Extensive choroidal abnormalities may be present in both groups, which are presumed to lie at the basis of the development of cCSC.

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Title: Patient characteristics of untreated chronic central serous chorioretinopathy patients with focal versus diffuse leakage
Authors: Thomas J. van Rijssen
Elon H. C. van Dijk
Paula Scholz
Myrte B. Breukink
Rocio Blanco-Garavito
Eric H. Souied
Robert E. MacLaren
Giuseppe Querques
Sascha Fauser
Carel B. Hoyng
Susan M. Downes
Camiel J. F. Boon
Publication date: 01-07-2019
Publisher: Springer Berlin Heidelberg
Keywords: Angiography
Photodynamic Therapy
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04333-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Patient characteristics of untreated chronic central serous chorioretinopathy patients with focal versus diffuse leakage

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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