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Open Access 01-10-2006 | REVIEW

Genetics of human hydrocephalus

Authors: Jun Zhang, Sc.D., PhD, Michael A. Williams, Daniele Rigamonti

Published in: Journal of Neurology | Issue 10/2006

Abstract

Human hydrocephalus is a common medical condition that is characterized by abnormalities in the flow or resorption of cerebrospinal fluid (CSF), resulting in ventricular dilatation. Human hydrocephalus can be classified into two clinical forms, congenital and acquired. Hydrocephalus is one of the complex and multifactorial neurological disorders.

A growing body of evidence indicates that genetic factors play a major role in the pathogenesis of hydrocephalus. An understanding of the genetic components and mechanism of this complex disorder may offer us significant insights into the molecular etiology of impaired brain development and an accumulation of the cerebrospinal fluid in cerebral compartments during the pathogenesis of hydrocephalus. Genetic studies in animal models have started to open the way for understanding the underlying pathology of hydrocephalus. At least 43 mutants/loci linked to hereditary hydrocephalus have been identified in animal models and humans. Up to date, 9 genes associated with hydrocephalus have been identified in animal models. In contrast, only one such gene has been identified in humans. Most of known hydrocephalus gene products are the important cytokines, growth factors or related molecules in the cellular signal pathways during early brain development. The current molecular genetic evidence from animal models indicate that in the early development stage, impaired and abnormal brain development caused by abnormal cellular signaling and functioning, all these cellular and developmental events would eventually lead to the congenital hydrocephalus.

Owing to our very primitive knowledge of the genetics and molecular pathogenesis of human hydrocephalus, it is difficult to evaluate whether data gained from animal models can be extrapolated to humans. Initiation of a large population genetics study in humans will certainly provide invaluable information about the molecular and cellular etiology and the developmental mechanisms of human hydrocephalus.

This review summarizes the recent findings on this issue among human and animal models, especially with reference to the molecular genetics, pathological, physiological and cellular studies, and identifies future research directions.

Schurr PH, McLaurin RL, Ingraham FD (1953) Experimental studies on the circulation of the cerebrospinal fluid and methods of producing communicating hydrocephalus in the dog. J Neurosurg 10:515–525PubMed

Czosnyka M, Czosnyka Z, Schmidt EA, et al. (2003) Cerebrospinal fluid production. J Neurosurg 99:206–207 author reply 207PubMed

Willems PJ (1988) Heterogeneity in familial hydrocephalus. Am J Med Genet 31:471–473PubMed

Price JR, Horne BM (1968) Family history indicating hereditary factors in hydrocephalus. Ment Retard 6:40–41PubMed

Tipton RE (1971) Familial hydrocephalus. Birth Defects Orig Artic Ser 7:231PubMed

Stoll C, Alembik Y, Dott B, et al. (1992) An epidemiologic study of environmental and genetic factors in congenital hydrocephalus. Eur J Epidemiol 8:797–803PubMed

Mori K, Shimada J, Kurisaka M, et al. (1995) Classification of hydrocephalus and outcome of treatment. Brain Dev 17:338–348PubMed

Mori K (1990) Hydrocephalus–revision of its definition and classification with special reference to “intractable infantile hydrocephalus”. Childs Nerv Syst 6:198–204PubMed

Mori K (1995) Current concept of hydrocephalus: evolution of new classifications. Childs Nerv Syst 11:523–531 discussion p 531–522

10.

Haverkamp F, Wolfle J, Aretz M, et al. (1999) Congenital hydrocephalus internus and aqueduct stenosis: aetiology and implications for genetic counselling. Eur J Pediatr 158:474–478PubMed

11.

Chahlavi A, El-Babaa SK, Luciano MG (2001) Adult-onset hydrocephalus. Neurosurg Clin N Am 12:753–760, ixPubMed

12.

Czosnyka M., Richards HK, Czosnyka Z, et al. (2004) Normal-pressure hydrocephalus. J Neurosurg 101:1083–1084 author reply 1084PubMed

13.

Adams C, Johnston WP, Nevin NC (1982) Family study of congenital hydrocephalus. Dev Med Child Neurol 24:493–498PubMedCrossRef

14.

Fernell E, Hagberg B, Hagberg G, et al. (1986) Epidemiology of infantile hydrocephalus in Sweden. I. Birth prevalence and general data. Acta Paediatr Scand 75:975–981PubMed

15.

Teebi AS, Naguib KK (1988) Autosomal recessive nonsyndromal hydrocephalus. Am J Med Genet 31:467–470PubMed

16.

Partington MD (2001) Congenital hydrocephalus. Neurosurg Clin N Am 12:737–742, ixPubMed

17.

Shannon MW, Nadler HL (1968) X-linked hydrocephalus. J Med Genet 5:326–328PubMed

18.

Kuzniecky RI, Watters GV, Watters L, et al. (1986) X-linked hydrocephalus. Can J Neurol Sci 13:344–346PubMed

19.

Jansen J (1975) Sex-linked hydrocephalus. Dev Med Child Neurol 17:633–640PubMedCrossRef

20.

Halliday J, Chow CW, Wallace D, et al. (1986) X linked hydrocephalus: a survey of a 20 year period in Victoria, Australia. J Med Genet 23:23–31PubMed

21.

Sakata-Haga H, Sawada K, Ohnishi T, et al. (2004) Hydrocephalus following prenatal exposure to ethanol. Acta Neuropathol (Berl) 108:393–398

22.

Castro-Gago M, Novo I, Pena J (1987) Maternal alcohol ingestion and neural tube defects: observation of four brothers in a family. Brain Dev 9:321–322PubMed

23.

Schinazi RF, Yao X (1995) Hydrocephalus induction in mice infected with herpes simplex virus type 2 after antiviral treatment. Antiviral Res 28:291–302PubMed

24.

Stahl W, Kaneda Y (1997) Pathogenesis of murine toxoplasmic hydrocephalus. Parasitology 114( Pt 3): 219–229PubMed

25.

Tsunoda I, McCright IJ, Kuang LQ, et al. (1997) Hydrocephalus in mice infected with a Theiler’s murine encephalomyelitis virus variant. J Neuropathol Exp Neurol 56:1302–1313PubMed

26.

Aolad HM, Inouye M, Hayasaka S, et al. (1998) Congenital hydrocephalus caused by exposure to low level X-radiation at early gestational stage in mice. Biol Sci Space 12:256–257PubMed

27.

Aolad HM, Inouye M, Darmanto W, et al. (2000) Hydrocephalus in mice following X-irradiation at early gestational stage: possibly due to persistent deceleration of cell proliferation. J Radiat Res (Tokyo) 41:213–226

28.

Bay C, Kerzin L, Hall BD (1979) Recurrence risk in hydrocephalus. Birth Defects Orig Artic Ser 15:95–105PubMed

29.

Burton BK (1979A) Empiric recurrence risks for congenital hydrocephalus. Birth Defects Orig Artic Ser 15:107–115

30.

Burton BK (1979B) Recurrence risks for congenital hydrocephalus. Clin Genet 16:47–53CrossRef

31.

Barros-Nunes P, Rivas F (1993) Autosomal recessive congenital stenosis of aqueduct of Sylvius. Genet Couns 4:19–23PubMed

32.

Chow CW, McKelvie PA, Anderson RM, et al. (1990) Autosomal recessive hydrocephalus with third ventricle obstruction. Am J Med Genet 35:310–313PubMed

33.

Abdul-Karim R, Iliya F, Iskandar G (1964) Consecutive Hydrocephalus: Report of 2 Cases. Obstet Gynecol 24:376–378PubMed

34.

Game K, Friedman JM, Paradice B, et al. (1989) Fetal growth retardation, hydrocephalus, hypoplastic multilobed lungs, and other anomalies in 4 sibs. Am J Med Genet 33:276–279PubMed

35.

Zlotogora J, Sagi M, Cohen T (1994) Familial hydrocephalus of prenatal onset. Am J Med Genet 49:202–204PubMed

36.

Zlotogora J (1997) Autosomal recessive diseases among Palestinian Arabs. J Med Genet 34:765–766PubMed

37.

Zlotogora J (1997) Genetic disorders among Palestinian Arabs. 2. Hydrocephalus and neural tube defects. Am J Med Genet 71:33–35

38.

Castro-Gago M, Alonso A, Eiris-Punal J (1996) Autosomal recessive hydrocephalus with aqueductal stenosis. Childs Nerv Syst 12:188–191PubMed

39.

Chudley AE, McCullough C, McCullough DW (1997) Bilateral sensorineural deafness and hydrocephalus due to foramen of Monro obstruction in sibs: a newly described autosomal recessive disorder. Am J Med Genet 68:350–356PubMed

40.

Moog U, Bleeker-Wagemakers EM, Crobach P, et al. (1998) Sibs with Axenfeld-Rieger anomaly, hydrocephalus, and leptomeningeal calcifications: a new autosomal recessive syndrome? Am J Med Genet 78:263–266PubMed

41.

Chalmers RM, Andreae L, Wood NW, et al. (1999) Familial hydrocephalus. J Neurol Neurosurg Psychiatry 67:410–411PubMed

42.

Hamada H, Watanabe H, Sugimoto M, et al. (1999) Autosomal recessive hydrocephalus due to congenital stenosis of the aqueduct of sylvius. Prenat Diagn 19:1067–1069PubMed

43.

Castro-Gago M, Pintos-Martinez E, Forteza-Vila J, et al. (2001) Congenital hydranencephalic-hydrocephalic syndrome with proliferative vasculopathy: a possible relation with mitochondrial dysfunction. J Child Neurol 16:858–862PubMed

44.

Verhagen WI, Bartels RH, Fransen E, et al. (1998) Familial congenital hydrocephalus and aqueduct stenosis with probably autosomal dominant inheritance and variable expression. J Neurol Sci 158:101–105PubMed

45.

Vincent C, Kalatzis V, Compain S, et al. (1994) A proposed new contiguous gene syndrome on 8q consists of Branchio-Oto-Renal (BOR) syndrome, Duane syndrome, a dominant form of hydrocephalus and trapeze aplasia; implications for the mapping of the BOR gene. Hum Mol Genet 3:1859–1866PubMed

46.

Jouet M, Rosenthal A, MacFarlane J, et al. (1993) A missense mutation confirms the L1 defect in X-linked hydrocephalus (HSAS). Nat Genet 4:331PubMed

47.

Owler BK, Pickard JD (2001) Normal pressure hydrocephalus and cerebral blood flow: a review. Acta Neurol Scand 104:325–342PubMed

48.

Edwards RJ, Dombrowski SM, Luciano MG, et al. (2004) Chronic hydrocephalus in adults. Brain Pathol 14:325–336PubMedCrossRef

49.

Katsuragi S, Teraoka K, Ikegami K, et al. (2000) Late onset X-linked hydrocephalus with normal cerebrospinal fluid pressure. Psychiatry Clin Neurosci 54:487–492PubMed

50.

Portenoy RK, Berger A, Gross E (1984) Familial occurrence of idiopathic normal-pressure hydrocephalus. Arch Neurol 41:335–337PubMed

51.

Robertson JM, Samankova L, Ingalls TH. (1966) Hydrocephalus and cleft palate in an inbred rabbit colony. J Hered 57:142–148PubMed

52.

Mori A (1968) [Hereditary hydrocephalus in C57BL mouse]. No To Shinkei 20:695–700PubMed

53.

Silson M, Robinson R (1969) Hereditary hydrocephalus in the cat. Vet Rec 84:477PubMed

54.

Taraszewska A, Zaleska-Rutczynska Z (1970) Congenital hydrocephalus in mice of strains BN and C57BL. Pol Med J 9:187–195PubMed

55.

Yoon CH, Slaney J (1972) Hydrocephalus: a new mutation in the Syrian golden hamster. J Hered 63:344–346PubMed

56.

Yoon CH, Peterson JS (1977) Linkage group II in the Syrian hamster. Linkage between hydrocephalus and cream coat color. J Hered 68:418

57.

Leipold HW, Schalles R (1977) Genetic defects in cattle: transmission and control. Vet Med Small Anim Clin 72:80–85PubMed

58.

Park AW, Nowosielski-Slepowron BJ (1979) Hydrocephalus in the laboratory rat. Acta Morphol Neerl Scand 17:191–207PubMed

59.

Kohn DF, Chinookoswong N, Chou SM (1984) Animal model of human disease. Congenital hydrocephalus. Am J Pathol 114:184–185PubMed

60.

Weller RO, Williams BN (1975) Cerebral biopsy and assessment of brain damage in hydrocephalus. Arch Dis Child 50:763–768PubMedCrossRef

61.

Bruni JE, Del Bigio MR, Cardoso ER, et al. (1988) Hereditary hydrocephalus in laboratory animals and humans. Exp Pathol 35:239–246PubMed

62.

Jones HC (1984) The development of congenital hydrocephalus in the mouse. Z Kinderchir 39 Suppl 2:87–88

63.

Jones HC, Bucknall RM (1988) Inherited prenatal hydrocephalus in the H-Tx rat: a morphological study. Neuropathol Appl Neurobiol 14:263–274PubMedCrossRef

64.

Oi S, Yamada H, Sato O, et al. (1996) Experimental models of congenital hydrocephalus and comparable clinical problems in the fetal and neonatal periods. Childs Nerv Syst 12:292–302PubMed

65.

Jones HC, Carter BJ, Depelteau JS, et al. (2001) Chromosomal linkage associated with disease severity in the hydrocephalic H-Tx rat. Behav Genet 31:101–111PubMed

66.

Jones HC, Depelteau JS, Carter BJ, et al. (2001) Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat. Mamm Genome 12:22–26PubMed

67.

Jones HC, Depelteau JS, Carter BJ, et al. (2002) The frequency of inherited hydrocephalus is influenced by intrauterine factors in H-Tx rats. Exp Neurol 176:213–220PubMed

68.

Jones HC, Yehia B, Chen GF, et al. (2004) Genetic analysis of inherited hydrocephalus in a rat model. Exp Neurol 190:79–90PubMed

69.

Cai X, McGraw G, Pattisapu JV, et al. (2000) Hydrocephalus in the H-Tx rat: a monogenic disease? Exp Neurol 163:131–135PubMed

70.

Sasaki S, Goto H, Nagano H, et al. (1983) Congenital hydrocephalus revealed in the inbred rat, LEW/Jms. Neurosurgery 13:548–554PubMed

71.

Jones HC, Carter BJ, Morel L (2003) Characteristics of hydrocephalus expression in the LEW/Jms rat strain with inherited disease. Childs Nerv Syst 19:11–18PubMed

72.

Zygourakis CC, Rosen GD (2003) Quantitative trait loci modulate ventricular size in the mouse brain. J Comp Neurol 461:362–369PubMed

73.

Clark F (1932) Hydrocephalus, a hereditary character in the house mouse. Proc Natl Acad Sci USA 18:654–656PubMed

74.

Clark F (1934) Anatomical basis of a hereditary hydrocephalus in the house mouse. Anat Rec 58:225–233

75.

Zimmermann K (1933) Eine neue Mutation der Hausmaus: “hydrocephalus”. Z Indukt Abstamm Vererbungsl 64:176–180

76.

Clark F (1935) Two hereditary types of hydrocephalus in the house mouse (Mus musculus). Proc Natl Acad Sci USA 21(3): 150–152PubMed

77.

Dickie M (1968) Obstructive hydrocephalus. Mouse News Lett 39:27

78.

Borit A, Sidman RL (1972) New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. Acta Neuropathol (Berl) 21:316–331

79.

Gruneberg H (1943) Two new mutant genes in the house mouse. J Genet 45:22–28

80.

Raimondi AJ, Bailey OT, McLone DG, et al. (1973) The pathophysiology and morphology of murine hydrocephalus in Hy-3 and Ch mutants. Surg Neurol 1:50–55PubMed

81.

Robinson ML, Allen CE, Davy BE, et al. (2002) Genetic mapping of an insertional hydrocephalus-inducing mutation allelic to hy3. Mamm Genome 13:625–632PubMed

82.

Davy BE, Robinson ML (2003) Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. Hum Mol Genet 12:1163–1170PubMed

83.

Blackshear PJ, Graves JP, Stumpo DJ, et al. (2003) Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Development 130:4539–4552PubMed

84.

Kume T, Deng KY, Winfrey V, et al. (1998) The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. Cell 93:985–996PubMed

85.

Hong HK, Lass JH, Chakravarti A (1999) Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcriptionfactor gene. Hum Mol Genet 8:625–637PubMed

86.

Descipio C, Schneider L, Young TL, et al. (2005) Subtelomeric deletions of chromosome 6p: molecular and cytogenetic characterization of three new cases with phenotypic overlap with Ritscher-Schinzel (3C) syndrome. Am J Med Genet A 134:3–11PubMed

87.

Hong HK, Chakravarti A, Takahashi JS (2004) The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice. Proc Natl Acad Sci USA 101:1748–1753PubMed

88.

Kuwamura M, Kinoshita A, Okumoto M, et al. (2004) Hemorrhagic hydrocephalus (hhy): a novel mutation on mouse chromosome 12. Brain Res Dev Brain Res 152:69–72PubMed

89.

Abdelilah S, Mountcastle-Shah E, Harvey M, et al. (1996) Mutations affecting neural survival in the zebrafish Danio rerio. Development 123:217–227PubMed

90.

Driever W, Solnica-Krezel L, Schier AF, et al. (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development 123:37–46PubMed

91.

Sheen VL, Basel-Vanagaite L, Goodman JR, et al. (2004) Etiological heterogeneity of familial periventricular heterotopia and hydrocephalus. Brain Dev 26:326–334PubMed

92.

Miyan JA, Khan MI, Kawarada Y, et al. (1998) Cell death in the brain of the HTx rat. Eur J Pediatr Surg 8 Suppl 1:43–48PubMed

93.

Mori F, Tanji K, Yoshida Y, et al. (2002) Thalamic retrograde degeneration in the congenitally hydrocephalic rat is attributable to apoptotic cell death. Neuropathology 22:186–193PubMed

94.

Draper CE, Owen-Lynch PJ, Bannister CM, et al. (2001) Proliferation of cerebral cortical cells from the hydrocephalic HTx rat: an in vitro study. Eur J Pediatr Surg 11 Suppl 1:S51–52

95.

Mashayekhi F, Bannister CM, Miyan JA (2001) Failure in cell proliferation in the germinal epithelium of the HTx rats. Eur J Pediatr Surg 11 Suppl 1:S57–59

96.

Somera KC, Jones HC (2004) Reduced subcommissural organ glycoprotein immunoreactivity precedes aqueduct closure and ventricular dilatation in H-Tx rat hydrocephalus. Cell Tissue Res 315:361–373PubMed

97.

Somera KC, Jones H (2002) Subcommissural organ dysfunction in H-Tx rats with early-onset hydrocephalus. Eur J Pediatr Surg 12 Suppl 1:S45–47

98.

Ulfig N, Bohl J, Neudorfer F, et al. (2004) Brain macrophages and microglia in human fetal hydrocephalus. Brain Dev 26:307–315PubMed

99.

Okamoto N, Del Maestro R, Valero R, et al. (2004) Hydrocephalus and Hirschsprung’s disease with a mutation of L1CAM. J Hum Genet 49:334–337PubMed

100.

Chae TH, Kim S, Marz KE, et al. (2004) The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate. Nat Genet 36:264–270PubMed

101.

Kondziella D, Qu H, Ludemann W, et al. (2003) Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus. J Neurochem 85:274–281PubMedCrossRef

102.

Takano T, Mekata Y, Yamano T, et al. (1993) Early ependymal changes in experimental hydrocephalus after mumps virus inoculation in hamsters. Acta Neuropathol (Berl) 85:521–525

103.

Takano T, Rutka JT, Becker LE (1996) Overexpression of nestin and vimentin in ependymal cells in hydrocephalus. Acta Neuropathol (Berl) 92:90–97

104.

Jimenez AJ, Tome M, Paez P, et al. (2001) A programmed ependymal denudation precedes congenital hydrocephalus in the hyh mutant mouse. J Neuropathol Exp Neurol 60:1105–1119PubMed

105.

Wagner C, Batiz LF, Rodriguez S, et al. (2003) Cellular mechanisms involved in the stenosis and obliteration of the cerebral aqueduct of hyh mutant mice developing congenital hydrocephalus. J Neuropathol Exp Neurol 62:1019–1040PubMed

106.

Ibanez-Tallon I, Pagenstecher A, Fliegauf M, et al. (2004) Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation. Hum Mol Genet 13:2133–2141PubMed

107.

Fernandez-Llebrez P, Grondona JM, Perez J, et al. (2004) Msx1-deficient mice fail to form prosomere 1 derivatives, subcommissural organ, and posterior commissure and develop hydrocephalus. J Neuropathol Exp Neurol 63:574–586PubMed

108.

Ramos C, Fernandez-Llebrez P, Bach A, et al. (2004) Msx1 disruption leads to diencephalon defects and hydrocephalus. Dev Dyn 230:446–460PubMed

109.

Fukumitsu H, Ohmiya M, Nitta A, et al. (2000) Aberrant expression of neurotrophic factors in the ventricular progenitor cells of infant congenitally hydrocephalic rats. Childs Nerv Syst 16:516–521PubMed

110.

Ohmiya M, Fukumitsu H, Nitta A, et al. (2001) Administration of FGF-2 to embryonic mouse brain induces hydrocephalic brain morphology and aberrant differentiation of neurons in the postnatal cerebral cortex. J Neurosci Res 65:228–235PubMed

111.

Miyan JA, Mashayekhi F, Bannister CM (2001) Developmental abnormalities in early-onset hydrocephalus: clues to signalling. Symp Soc Exp Biol 91–106

112.

Galbreath E, Kim SJ, Park K, et al. (1995) Overexpression of TGF-beta 1 in the central nervous system of transgenic mice results in hydrocephalus. J Neuropathol Exp Neurol 54:339–349PubMed

113.

Cohen AR, Leifer DW, Zechel M, et al. (1999) Characterization of a model of hydrocephalus in transgenic mice. J Neurosurg 91:978–988PubMedCrossRef

114.

Li X, Miyajima M, Arai H (2005) Analysis of TGF-beta2 and TGF-beta3 expression in the hydrocephalic H-Tx rat brain. Childs Nerv Syst 21:32–38PubMed

115.

Doublier S, Duyckaerts C, Seurin D, et al. (2000) Impaired brain development and hydrocephalus in a line of transgenic mice with liver-specific expression of human insulin-like growth factor binding protein-1. Growth Horm IGF Res 10:267–274PubMed

116.

Nitta J, Tada T (1998) Ultramicroscopic structures of the leptomeninx of mice with communicating hydrocephalus induced by human recombinant transforming growth factor-beta 1. Neurol Med Chir (Tokyo) 38:819–824 discussion 824–815CrossRef

117.

Johanson CE, Szmydynger-Chodobska J, Chodobski A, et al. (1999) Altered formation and bulk absorption of cerebrospinal fluid in FGF-2-induced hydrocephalus. Am J Physiol 277:R263–271PubMed

118.

Krebs DL, Metcalf D, Merson TD, et al. (2004) Development of hydrocephalus in mice lacking SOCS7. Proc Natl Acad Sci USA 101:15446–15451PubMed

119.

Zechel J, Gohil H, Lust WD, et al. (2002) Alterations in matrix metalloproteinase-9 levels and tissue inhibitor of matrix metalloproteinases-1 expression in a transforming growth factor-beta transgenic model of hydrocephalus. J Neurosci Res 69:662–668PubMed

120.

Crews L, Wyss-Coray T, Masliah E (2004) Insights into the pathogenesis of hydrocephalus from transgenic and experimental animal models. Brain Pathol 14:312–316PubMedCrossRef

121.

Tullio AN, Bridgman PC, Tresser NJ, et al. (2001) Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain. J Comp Neurol 433:62–74PubMed

122.

Makiyama Y, Shoji S, Mizusawa H (1997) Hydrocephalus in the Otx2+/− mutant mouse. Exp Neurol 148:215–221PubMed

123.

Jones HC, Harris NG, Rocca JR, Anderson RW (2000) Progressive tissue injury in infantile hydrocephalus and prevention/reversal with shunt treatment. Neurol Res 22:89–96PubMed

Title: Genetics of human hydrocephalus
Authors: Jun Zhang, Sc.D., PhD
Michael A. Williams
Daniele Rigamonti
Publication date: 01-10-2006
Publisher: Steinkopff-Verlag
Published in: Journal of Neurology / Issue 10/2006
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-006-0245-5

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Genetics of human hydrocephalus

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