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01-10-2006 | ORIGINAL COMMUNICATION

Spect measurements of regional cerebral perfusion and carbondioxide reactivity: Correlation with cerebral collaterals in internal carotid artery occlusive disease

Authors: Michiel J. de Boorder, MSc, Jeroen van der Grond, PhD, Alice J. van Dongen, MSc, Catharina J.M. Klijn, MD, L. Jaap Kappelle, MD, Peter P. Van Rijk, MD, Jeroen Hendrikse, MD, PhD

Published in: Journal of Neurology | Issue 10/2006

Abstract

Background

The aim of the present study was to assess the regional variation in cerebral perfusion, vasomotor reactivity (VMR) and the role of cerebral collaterals in patients with symptomatic internal carotid artery (ICA).

Methods

Seventeen functionally independent patients (60±9 years, mean±SD) with a unilateral symptomatic internal carotid artery occlusion and a <30% contralateral ICA stenosis were investigated. (99 m) Tc-hexamethyl propyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) was performed to study cerebral blood flow in rest and during a CO₂ challenge in the cerebellum, temporal lobe, occipital lobe, basal ganglia, frontal lobe and parietal lobe. Time of flight and phase contrast MRA were used to study collateral flow via circle of Willis.

Results

In rest, cerebral perfusion on the side ipsilateral to the ICA occlusion was decreased compared with the contralateral side in the basal ganglia (p<0.05), frontal lobe (p<0.01) and parietal lobe (p<0.01). During a CO₂ challenge only the ipsilateral frontal lobe demonstrated a perfusion decrease compared with the contralateral frontal lobe (p<0.05). Furthermore, in patients without collateral flow via the anterior circle of Willis the perfusion of the ipsilateral frontal lobe was significantly decreased (p<0.01) during the CO₂ challenge and crossed cerebellar diaschisis with a decreased perfusion on the contralateral cerebellar hemisphere was detected (p<0.05). No cerebral blood flow (CBF) differences were found for present/absent collateral flow via the posterior communicating artery.

Conclusion

Regional assessment of cerebral perfusion and VMR with SPECT demonstrated the heterogeneity of cerebral hemodynamics and the importance of collateral flow via the anterior circle of Willis.

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Title: Spect measurements of regional cerebral perfusion and carbondioxide reactivity: Correlation with cerebral collaterals in internal carotid artery occlusive disease
Authors: Michiel J. de Boorder, MSc
Jeroen van der Grond, PhD
Alice J. van Dongen, MSc
Catharina J.M. Klijn, MD
L. Jaap Kappelle, MD
Peter P. Van Rijk, MD
Jeroen Hendrikse, MD, PhD
Publication date: 01-10-2006
Publisher: Steinkopff-Verlag
Published in: Journal of Neurology / Issue 10/2006
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-006-0192-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Spect measurements of regional cerebral perfusion and carbondioxide reactivity: Correlation with cerebral collaterals in internal carotid artery occlusive disease

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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