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01-10-2004 | Original Article

Mitochondrial DNA control region sequences from Nairobi (Kenya): inferring phylogenetic parameters for the establishment of a forensic database

Authors: Anita Brandstätter, Christine T. Peterson, Jodi A. Irwin, Solomon Mpoke, Davy K. Koech, Walther Parson, Thomas J. Parsons

Published in: International Journal of Legal Medicine | Issue 5/2004

Abstract

Large forensic mtDNA databases which adhere to strict guidelines for generation and maintenance, are not available for many populations outside of the United States and western Europe. We have established a high quality mtDNA control region sequence database for urban Nairobi as both a reference database for forensic investigations, and as a tool to examine the genetic variation of Kenyan sequences in the context of known African variation. The Nairobi sequences exhibited high variation and a low random match probability, indicating utility for forensic testing. Haplogroup identification and frequencies were compared with those reported from other published studies on African, or African-origin populations from Mozambique, Sierra Leone, and the United States, and suggest significant differences in the mtDNA compositions of the various populations. The quality of the sequence data in our study was investigated and supported using phylogenetic measures. Our data demonstrate the diversity and distinctiveness of African populations, and underline the importance of establishing additional forensic mtDNA databases of indigenous African populations.

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Title: Mitochondrial DNA control region sequences from Nairobi (Kenya): inferring phylogenetic parameters for the establishment of a forensic database
Authors: Anita Brandstätter
Christine T. Peterson
Jodi A. Irwin
Solomon Mpoke
Davy K. Koech
Walther Parson
Thomas J. Parsons
Publication date: 01-10-2004
Publisher: Springer-Verlag
Published in: International Journal of Legal Medicine / Issue 5/2004
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-004-0466-z

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Mitochondrial DNA control region sequences from Nairobi (Kenya): inferring phylogenetic parameters for the establishment of a forensic database

Abstract

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