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Published in: Lung 5/2013

01-10-2013

Age Dependency of Oxygen Uptake and Related Parameters in Exercise Testing: An Expert Opinion on Reference Values Suitable for Adults

Author: Joachim Schneider

Published in: Lung | Issue 5/2013

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Abstract

Background

Spiroergometry has been established to determine physical capacity. Reference values collected mostly in a younger population can be obtained from a number of studies and therefore may differ. Regression equations are complex and cannot be transferred easily to clinical practice. Our aim was to obtain reference values for spiroergometric parameters in cardiopulmonary exercise in healthy adult populations.

Methods

Eighteen studies of healthy adults (>40 years) that assessed maximal oxygen uptake (VO2max), oxygen uptake in relation to body weight (VO2max/kg), and oxygen pulse (VO2max/heart rate) were included. After data processing, spiroergometric parameters were correlated to age. Regression analysis was performed separately for each study and also weighted with the number of participants.

Results

For all spiroergometric parameters, age dependency was detectable for both males and females. After performing regression analysis, the following linear regression equations were determined: VO2max: Males = −28 × age (years) + 4,000; females = −20 × age (years) + 2,700 (ml/min); VO2max/kg: Males = −0.42 × age (years) + 58; females = −0.35 × age (years) + 46 (ml/min/kg); VO2max/heart rate: Males = −0.10 × age (years) + 20.50; females = −0.05 × age (years) + 13 (ml/min/heart rate).

Conclusions

The present study provides practicable reference values for the spiroergometric parameters of adult men and women.
Literature
1.
go back to reference Preisser AM, Ochmann U (2011) Cardiopulmonary exercise testing in occupational medical fitness examination and assessment. Pneumologie 65:662–670PubMedCrossRef Preisser AM, Ochmann U (2011) Cardiopulmonary exercise testing in occupational medical fitness examination and assessment. Pneumologie 65:662–670PubMedCrossRef
2.
go back to reference Posner JD, Gorman KM, Klein HS, Cline CJ (1987) Ventilatory threshold: measurement and variation with age. J Appl Physiol 63:1519–1525PubMed Posner JD, Gorman KM, Klein HS, Cline CJ (1987) Ventilatory threshold: measurement and variation with age. J Appl Physiol 63:1519–1525PubMed
3.
go back to reference Takeshima N, Kobayashi F, Watanabe T, Tanaka K, Tomita M, Pollock ML (1996) Cardiorespiratory responses to cycling exercise in trained and untrained elderly: with special reference to the lactate threshold. Appl Human Sci 15:267–273PubMedCrossRef Takeshima N, Kobayashi F, Watanabe T, Tanaka K, Tomita M, Pollock ML (1996) Cardiorespiratory responses to cycling exercise in trained and untrained elderly: with special reference to the lactate threshold. Appl Human Sci 15:267–273PubMedCrossRef
4.
go back to reference Neder JA, Nery LE, Castelo A, Andreoni S, Lerario MC, Sachs A et al (1999) Prediction of metabolic and cardiopulmonary responses to maximum cycle ergometry: a randomised study. Eur Respir J 14:1304–1313PubMedCrossRef Neder JA, Nery LE, Castelo A, Andreoni S, Lerario MC, Sachs A et al (1999) Prediction of metabolic and cardiopulmonary responses to maximum cycle ergometry: a randomised study. Eur Respir J 14:1304–1313PubMedCrossRef
5.
go back to reference Koch B, Schäper C, Ittermann T, Spielhagen T, Dörr M, Völzke H et al (2009) Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study. Eur Respir J 33:389–397PubMedCrossRef Koch B, Schäper C, Ittermann T, Spielhagen T, Dörr M, Völzke H et al (2009) Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study. Eur Respir J 33:389–397PubMedCrossRef
6.
go back to reference Jones NL, Makrides L, Hitchcock C, Chypchar T, McCartney N (1985) Normal standards for an incremental progressive cycle ergometer test. Am Rev Respir Dis 131:700–708PubMed Jones NL, Makrides L, Hitchcock C, Chypchar T, McCartney N (1985) Normal standards for an incremental progressive cycle ergometer test. Am Rev Respir Dis 131:700–708PubMed
7.
go back to reference Pothoff G, Winter U, Wassermann K, Jäkel D, Steinbach M (1994) Ergospirometric studies of normal probands for an unsteady-state increment test program. Z Kardiol 83:116–123PubMed Pothoff G, Winter U, Wassermann K, Jäkel D, Steinbach M (1994) Ergospirometric studies of normal probands for an unsteady-state increment test program. Z Kardiol 83:116–123PubMed
8.
go back to reference Saltin B, Grimby G (1968) Physiological analysis of middle-aged and old former athletes: comparison with still active athletes of the same ages. Circulation 38:1104–1115PubMedCrossRef Saltin B, Grimby G (1968) Physiological analysis of middle-aged and old former athletes: comparison with still active athletes of the same ages. Circulation 38:1104–1115PubMedCrossRef
9.
go back to reference Ong KC, Loo CM, Ong YY, Chan SP, Earnest A, Saw SM (2002) Predictive values for cardiopulmonary exercise testing in sedentary Chinese adults. Respirology 7:225–231PubMedCrossRef Ong KC, Loo CM, Ong YY, Chan SP, Earnest A, Saw SM (2002) Predictive values for cardiopulmonary exercise testing in sedentary Chinese adults. Respirology 7:225–231PubMedCrossRef
10.
go back to reference Åstrand I, Astrand PO, Hallbäck I, Kilbom A (1973) Reduction in maximal oxygen uptake with age. J Appl Physiol 35:649–654PubMed Åstrand I, Astrand PO, Hallbäck I, Kilbom A (1973) Reduction in maximal oxygen uptake with age. J Appl Physiol 35:649–654PubMed
11.
go back to reference Sidney KH, Shephard RJ (1977) Maximum and submaximum exercise tests in men and women in the seventh, eighth and ninth decades of life. J Appl Physiol 43:280–287PubMed Sidney KH, Shephard RJ (1977) Maximum and submaximum exercise tests in men and women in the seventh, eighth and ninth decades of life. J Appl Physiol 43:280–287PubMed
12.
go back to reference Blackie SP, Fairbarn MS, McElvaney GN, Morrison NJ, Wilcox PG, Pardy RL (1989) Prediction of maximal oxygen uptake and power during cycle ergometry in subjects older than 55 years of age. Am Rev Respir Dis 139:1424–1429PubMedCrossRef Blackie SP, Fairbarn MS, McElvaney GN, Morrison NJ, Wilcox PG, Pardy RL (1989) Prediction of maximal oxygen uptake and power during cycle ergometry in subjects older than 55 years of age. Am Rev Respir Dis 139:1424–1429PubMedCrossRef
13.
go back to reference Fairbarn MS, Blackie SP, McElvaney NG, Wiggs BR, Paré PD, Pardy RL (1994) Prediction of heart rate and oxygen uptake during incremental and maximal exercise in healthy adults. Chest 105:1365–1369PubMedCrossRef Fairbarn MS, Blackie SP, McElvaney NG, Wiggs BR, Paré PD, Pardy RL (1994) Prediction of heart rate and oxygen uptake during incremental and maximal exercise in healthy adults. Chest 105:1365–1369PubMedCrossRef
14.
go back to reference Funk M, Schneider J (2012) Spiroergometric reference values for the sociomedical assessment of performance in adults aged over 60 years. Pneumologie 66:329–337PubMedCrossRef Funk M, Schneider J (2012) Spiroergometric reference values for the sociomedical assessment of performance in adults aged over 60 years. Pneumologie 66:329–337PubMedCrossRef
15.
go back to reference Neder JA, Nery LE, Peres C, Whipp BJ (2001) Reference values for dynamic responses to incremental cycle ergometry in males and females aged 20 to 80. Am Respir Crit Care Med 164:1481–1486CrossRef Neder JA, Nery LE, Peres C, Whipp BJ (2001) Reference values for dynamic responses to incremental cycle ergometry in males and females aged 20 to 80. Am Respir Crit Care Med 164:1481–1486CrossRef
16.
go back to reference McDonough JR, Kusumi F, Bruce RA (1970) Variations in maximal oxygen intake with physical activity in middle-aged men. Circulation 41:743–752PubMedCrossRef McDonough JR, Kusumi F, Bruce RA (1970) Variations in maximal oxygen intake with physical activity in middle-aged men. Circulation 41:743–752PubMedCrossRef
17.
go back to reference Drinkwater BL, Horvath SM, Wells CL (1975) Aerobic power of females, ages 10 to 68. J Gerontol 30:385–394 Drinkwater BL, Horvath SM, Wells CL (1975) Aerobic power of females, ages 10 to 68. J Gerontol 30:385–394
18.
go back to reference Herdy AH, Uhlendorf D (2011) Reference values for cardiopulmonary exercise testing for sedentary and active men and women. Arq Bras Cardiol 96:54–59PubMedCrossRef Herdy AH, Uhlendorf D (2011) Reference values for cardiopulmonary exercise testing for sedentary and active men and women. Arq Bras Cardiol 96:54–59PubMedCrossRef
19.
go back to reference Bruce RA, Kusumi F, Hosmer D (1973) Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am Heart J 85:546–562PubMedCrossRef Bruce RA, Kusumi F, Hosmer D (1973) Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am Heart J 85:546–562PubMedCrossRef
20.
go back to reference Vogel JA, Patton JF, Mello RP, Daniels WL (1986) An analysis of aerobic capacity in a large United States population. J Appl Physiol 60:494–500PubMed Vogel JA, Patton JF, Mello RP, Daniels WL (1986) An analysis of aerobic capacity in a large United States population. J Appl Physiol 60:494–500PubMed
21.
go back to reference Inbar O, Oren A, Scheinowitz M, Rotstein A, Dlin R, Casaburi R (1994) Normal cardiopulmonary responses during incremental exercise in 20- to 70-yr old men. Med Sci Sports Exerc 26:538–546PubMed Inbar O, Oren A, Scheinowitz M, Rotstein A, Dlin R, Casaburi R (1994) Normal cardiopulmonary responses during incremental exercise in 20- to 70-yr old men. Med Sci Sports Exerc 26:538–546PubMed
22.
go back to reference Hansen JE, Sue DY, Wassermann K (1984) Predicted values for clinical exercise testing. Am Rev Respir Dis 129(Suppl):49–55 Hansen JE, Sue DY, Wassermann K (1984) Predicted values for clinical exercise testing. Am Rev Respir Dis 129(Suppl):49–55
23.
go back to reference Storer TW, Davis JA, Caiozzo VJ (1990) Accurate prediction of VO2max in cycle ergometry. Med Sci Sports Exerc 22:704–712PubMedCrossRef Storer TW, Davis JA, Caiozzo VJ (1990) Accurate prediction of VO2max in cycle ergometry. Med Sci Sports Exerc 22:704–712PubMedCrossRef
24.
go back to reference Lubinski W, Golczewski T (2010) Physiologically interpretable prediction equations for spirometric indexes. J Appl Physiol 108:1440–1446PubMedCrossRef Lubinski W, Golczewski T (2010) Physiologically interpretable prediction equations for spirometric indexes. J Appl Physiol 108:1440–1446PubMedCrossRef
25.
go back to reference Mohrer D, Liberati A, Tetzlaff J, Altman DG, for the PRISMA group (2009) Preferred reporting items for systematic review and mate-analyses: The PRISMA statement. PLoS Med 6:e1000097. doi:10.1371/journal.pmed.1000097 Mohrer D, Liberati A, Tetzlaff J, Altman DG, for the PRISMA group (2009) Preferred reporting items for systematic review and mate-analyses: The PRISMA statement. PLoS Med 6:e1000097. doi:10.​1371/​journal.​pmed.​1000097
Metadata
Title
Age Dependency of Oxygen Uptake and Related Parameters in Exercise Testing: An Expert Opinion on Reference Values Suitable for Adults
Author
Joachim Schneider
Publication date
01-10-2013
Publisher
Springer US
Published in
Lung / Issue 5/2013
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-013-9483-3

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