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Published in: Lung 6/2012

01-12-2012

Effect of Continuous Positive Airway Pressure on Hemoglobin A1c in Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-analysis

Authors: Imran H. Iftikhar, Robert P. Blankfield

Published in: Lung | Issue 6/2012

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Abstract

Background

There is little conclusive data regarding the effect of continuous positive airway pressure (CPAP) on glycated hemoglobin (HbA1c). An earlier meta-analysis included two randomized controlled trials (RCTs) and found no significant effect of CPAP on HbA1c. The meta-analysis presented here was conducted to include all relevant observational studies and RCTs on the effect of CPAP on HbA1c.

Methods

We searched the PubMed database for all studies published prior to March 2012 for trials of the effect of CPAP on HbA1c. Data from observational studies and RCTs that met the inclusion criteria were extracted for pre- and post-treatment HbA1c.

Results

A total of nine studies that included 151 subjects met the inclusion criteria. The duration of the studies ranged from 41 days to 6 months. The mean net change in the HbA1c was −0.06 % [95 % CI: −0.24, 0.12] (p = 0.5). Five of the nine studies, with a total of 112 subjects, comprised patients with diabetes mellitus (DM) type 2. The mean net change in HbA1c for the subjects with DM type 2 was 0.08 % [95 % CI: −0.26, 0.42] (p = 0.65). The mean net change in HbA1c for subjects with DM type 2 in studies that were at least 3 months in duration was 0.16 % [95 % CI: −0.26, 0.58] (p = 0.45).

Conclusions

This meta-analysis found that CPAP does not reduce HbA1c levels when used in the short term.
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Metadata
Title
Effect of Continuous Positive Airway Pressure on Hemoglobin A1c in Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-analysis
Authors
Imran H. Iftikhar
Robert P. Blankfield
Publication date
01-12-2012
Publisher
Springer-Verlag
Published in
Lung / Issue 6/2012
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-012-9404-x

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