Skip to main content
Top
Published in: Lung 1/2008

01-02-2008

Before We Get Started: What Is a Cough?

Author: Giovanni A. Fontana

Published in: Lung | Special Issue 1/2008

Login to get access

Abstract

Cough is an airway defensive reflex consisting of an inspiratory phase followed by a forced expiratory effort initially against a closed glottis, followed by active glottal opening and rapid expiratory flow. The expiration reflex (ER) differentiates from cough for the lack of a preparatory inspiration. The reflexes subserve different functions: cough will clear the lower airways from debris and mucus, while the expiration reflex will prevent aspiration. Clinically, a cough epoch is a sequence of motor acts resulting from a combination of true coughs and ERs that need to be accurately identified and measured for adequate quantitative description.
Literature
1.
go back to reference Anonymous (1973) The Shorter Oxford English Dictionary 3rd ed. Oxford: Clarendon Press, p 436 Anonymous (1973) The Shorter Oxford English Dictionary 3rd ed. Oxford: Clarendon Press, p 436
2.
go back to reference Morice AH, McGarvey L, Pavord I (2006) Recommendations for the management of cough in adults. Thorax 61(Suppl 1):1–24CrossRef Morice AH, McGarvey L, Pavord I (2006) Recommendations for the management of cough in adults. Thorax 61(Suppl 1):1–24CrossRef
3.
go back to reference Morice AH, Fontana GA, Belvisi MG, Birring SS, Chung KF, Dicpinigaitis PV, Kastelik JA, McGarvey LP, Smith JA, Tatar M, Widdicombe J, European Respiratory Society (2007) ERS guidelines on the assessment of cough. Eur Respir J 29:1256–1276PubMedCrossRef Morice AH, Fontana GA, Belvisi MG, Birring SS, Chung KF, Dicpinigaitis PV, Kastelik JA, McGarvey LP, Smith JA, Tatar M, Widdicombe J, European Respiratory Society (2007) ERS guidelines on the assessment of cough. Eur Respir J 29:1256–1276PubMedCrossRef
4.
go back to reference Korpas J, Tomori Z (1979) Cough and Other Respiratory Reflexes. Basel: Karger, pp 1–281 Korpas J, Tomori Z (1979) Cough and Other Respiratory Reflexes. Basel: Karger, pp 1–281
5.
go back to reference Leith DE (1977) Cough. In: Brain JD, Proctor DF, Reid LM (eds) Respiratory defense mechanisms. New York: Marcel Dekker, pp 545–592 Leith DE (1977) Cough. In: Brain JD, Proctor DF, Reid LM (eds) Respiratory defense mechanisms. New York: Marcel Dekker, pp 545–592
6.
go back to reference Williams CBJ (1841) Report of experiments on the physiology of the lungs and air-tubes. Rep Br Assn Adv Sci August: 411–420 Williams CBJ (1841) Report of experiments on the physiology of the lungs and air-tubes. Rep Br Assn Adv Sci August: 411–420
7.
go back to reference Shannon R, Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG (2004) Production of reflex cough by brainstem respiratory networks. Pulm Pharmacol Ther 6:369–381CrossRef Shannon R, Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG (2004) Production of reflex cough by brainstem respiratory networks. Pulm Pharmacol Ther 6:369–381CrossRef
8.
go back to reference Baekey DM, Morris KF, Nuding SG, Segars LS, Lindsey BG, Shannon R (2004) Ventrolateral medullary respiratory network participation in the expiration reflex in the cat. J Appl Physiol 96:2057–2072PubMedCrossRef Baekey DM, Morris KF, Nuding SG, Segars LS, Lindsey BG, Shannon R (2004) Ventrolateral medullary respiratory network participation in the expiration reflex in the cat. J Appl Physiol 96:2057–2072PubMedCrossRef
10.
go back to reference Tatar M, Hanacek J, Widdicombe J (2007) The expiration reflex from the trachea and bronchi. Eur Respir J (in press) Tatar M, Hanacek J, Widdicombe J (2007) The expiration reflex from the trachea and bronchi. Eur Respir J (in press)
11.
go back to reference Nishino T, Tagaito Y, Isono S (1996) Cough and other reflexes on irritation of airway mucosa in man. Pulm Pharmacol 9:285–292PubMedCrossRef Nishino T, Tagaito Y, Isono S (1996) Cough and other reflexes on irritation of airway mucosa in man. Pulm Pharmacol 9:285–292PubMedCrossRef
12.
go back to reference Young S, Abdul-Sattar N, Caric D (1987) Glottic closure and high flows are not necessary for productive cough. Bull Eur Physiolpathol Respir 23(Suppl 10):13S–17S Young S, Abdul-Sattar N, Caric D (1987) Glottic closure and high flows are not necessary for productive cough. Bull Eur Physiolpathol Respir 23(Suppl 10):13S–17S
13.
go back to reference Davenport PW, Sapienza CM, Bolser DC (2002) Psychophysical assessment of the urge-to-cough. Eur Respir Rev 12:249–253 Davenport PW, Sapienza CM, Bolser DC (2002) Psychophysical assessment of the urge-to-cough. Eur Respir Rev 12:249–253
14.
go back to reference Hsu J-Y, Stone RA, Logan-Sinclair R, Worsdell M, Busst C, Chung KF (1994) Coughing frequency in patients with persistent cough using a 24-hour ambulatory recorder. Eur Respir J 7:1246–1253PubMedCrossRef Hsu J-Y, Stone RA, Logan-Sinclair R, Worsdell M, Busst C, Chung KF (1994) Coughing frequency in patients with persistent cough using a 24-hour ambulatory recorder. Eur Respir J 7:1246–1253PubMedCrossRef
15.
go back to reference Barry SJ, Dane AD, Morice AH, Walmsley AD (2006) The automatic recognition and counting of cough. Cough 2:8PubMedCrossRef Barry SJ, Dane AD, Morice AH, Walmsley AD (2006) The automatic recognition and counting of cough. Cough 2:8PubMedCrossRef
16.
go back to reference Morata A, Ohota N, Shibuya A, Ono H, Kudoh S (2006) New non-invasive automatic cough counting program based on 6 types of classified cough sounds. Intern Med 45:391–397CrossRef Morata A, Ohota N, Shibuya A, Ono H, Kudoh S (2006) New non-invasive automatic cough counting program based on 6 types of classified cough sounds. Intern Med 45:391–397CrossRef
17.
18.
go back to reference Bucher K (1958) Pathophysiology and pharmacology of cough. Pharm Rev 10:43–58PubMed Bucher K (1958) Pathophysiology and pharmacology of cough. Pharm Rev 10:43–58PubMed
19.
go back to reference Strohl KP, Mead J, Banzett RB, Loring S, Kosch P (1981) Regional differences in abdominal muscle activity during various maneuvres in humans. J Appl Physiol 51:1471–1476PubMed Strohl KP, Mead J, Banzett RB, Loring S, Kosch P (1981) Regional differences in abdominal muscle activity during various maneuvres in humans. J Appl Physiol 51:1471–1476PubMed
20.
go back to reference De Troyer A, Loring SH (1986) Action of respiratory muscles. In: Handbook of Physiology. The Respiratory System. Mechanics of Breathing. Bethesda, MD: Am Physiol Soc, sect 3, vol III, chap 27, pp 1–67 De Troyer A, Loring SH (1986) Action of respiratory muscles. In: Handbook of Physiology. The Respiratory System. Mechanics of Breathing. Bethesda, MD: Am Physiol Soc, sect 3, vol III, chap 27, pp 1–67
21.
go back to reference Fontana GA, Pantaleo T, Lavorini F, Boddi V, Panuccio P (1997) A non-invasive electromyographic study on threshold and intensity of cough in humans. Eur Respir J 10:983–989PubMedCrossRef Fontana GA, Pantaleo T, Lavorini F, Boddi V, Panuccio P (1997) A non-invasive electromyographic study on threshold and intensity of cough in humans. Eur Respir J 10:983–989PubMedCrossRef
22.
go back to reference Fontana GA, Pantaleo T, Lavorini F, Polli G, Pistolesi M (1999) Coughing in laryngectomized patients. Am J Respir Crit Care Med 160:1578–1584PubMed Fontana GA, Pantaleo T, Lavorini F, Polli G, Pistolesi M (1999) Coughing in laryngectomized patients. Am J Respir Crit Care Med 160:1578–1584PubMed
23.
go back to reference Fontana GA, Pantaleo T, Lavorini F, Benvenuti F, Gangemi S (1998) Defective motor control of coughing in Parkinson’s disease. Am J Respir Crit Care Med 158:458–464PubMed Fontana GA, Pantaleo T, Lavorini F, Benvenuti F, Gangemi S (1998) Defective motor control of coughing in Parkinson’s disease. Am J Respir Crit Care Med 158:458–464PubMed
24.
go back to reference Lavorini F, Pantaleo T, Geri P, Mutolo D, Pistolesi M, Fontana GA (2007) Cough and ventilatory adjustments evoked by aerosolised capsaicin and distilled water (fog) in man. Respir Physiol Neurobiol 156:331–339PubMedCrossRef Lavorini F, Pantaleo T, Geri P, Mutolo D, Pistolesi M, Fontana GA (2007) Cough and ventilatory adjustments evoked by aerosolised capsaicin and distilled water (fog) in man. Respir Physiol Neurobiol 156:331–339PubMedCrossRef
25.
go back to reference Desmedt JE, Godaux E (1977) Ballistic contractions in man: characteristic recruitment pattern of single motor units in the tibialis anterior muscle. J. Physiol 264:673–693PubMed Desmedt JE, Godaux E (1977) Ballistic contractions in man: characteristic recruitment pattern of single motor units in the tibialis anterior muscle. J. Physiol 264:673–693PubMed
26.
go back to reference Bigland B, Lippold OCJ (1954) The relation between force, velocity and integrated electrical activity in human muscles. J Physiol (Lond) 123:214–224 Bigland B, Lippold OCJ (1954) The relation between force, velocity and integrated electrical activity in human muscles. J Physiol (Lond) 123:214–224
27.
go back to reference Fontana GA (2003) Motor mechanisms and the mechanics of cough. In: Chung F, Widdicombe J, Boushey H (eds) Cough: Causes, Mechanisms and Therapy. Oxford: Blackwell Publishing, pp 193–205CrossRef Fontana GA (2003) Motor mechanisms and the mechanics of cough. In: Chung F, Widdicombe J, Boushey H (eds) Cough: Causes, Mechanisms and Therapy. Oxford: Blackwell Publishing, pp 193–205CrossRef
Metadata
Title
Before We Get Started: What Is a Cough?
Author
Giovanni A. Fontana
Publication date
01-02-2008
Publisher
Springer-Verlag
Published in
Lung / Issue Special Issue 1/2008
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-007-9036-8

Other articles of this Special Issue 1/2008

Lung 1/2008 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.