Beneficial and adverse effects of ketamine and its enantiomers, and the underlying mechanisms of ECT and rTMS efficacy

Excerpt

Suicide represents a major global public health challenge, with a notably higher prevalence observed among individuals suffering from major depressive disorder (MDD) in comparison to the general population. Depression, widely recognized as a prevalent mental health disorder, is characterized by enduring sadness, diminished interest in activities, and a range of emotional and physical issues, all of which markedly elevate the risk of suicide. Recent meta-analysis findings have indicated that the severity of hopelessness is a significant predictor of suicidal ideation (SI) and suicide attempts [1]. Additionally, factors such as a history of suicide attempts, SI, severe depression, and psychotic symptoms have been identified as predictors of subsequent suicide attempts and suicide deaths [1]. In this issue, a scoping review by Phalen et al. [2] explores the notion that emotional distress and dysregulation could serve as promising therapeutic targets for addressing suicide in individuals with psychosis. Overall, the urgent need for the development of effective depression treatments remains a critical gap in the effort to prevent suicide. …