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European Archives of Psychiatry and Clinical Neuroscience

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01-09-2011 | Original Paper

A visual [18F]FDG-PET rating scale for the differential diagnosis of frontotemporal lobar degeneration

Authors: Stefan Poljansky, Bernd Ibach, Barbara Hirschberger, Peter Männer, Hans Klünemann, Göran Hajak, Jörg Marienhagen

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 6/2011

Abstract

This study presents a visual rating scale for the assessment of cerebral [¹⁸F]fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) scans to characterize typical findings in dementias associated with frontotemporal lobar degeneration (FTLD) and to differentiate individual patients with FTLD compared to Alzheimer’s disease (AD) and mild cognitive impairment (MCI). A total of 43 cerebral PET scans from patients with FTLD (n = 16, mean age 58.4 years), AD (n = 16, 59.9 years) and MCI (n = 11, 57.9 years) were analysed. Every PET data set was visually rated for seven brain regions on each hemisphere (frontal lobe, temporal lobe, parietal lobe, occipital lobe, basal ganglia, thalamus and cerebellum). The extent of the impairment in metabolism was classified as absent, mild, medium or strong. Using this four-stage visual rating scale, characteristic profiles of metabolic impairment in FTLD, AD, MCI and the FTLD-subgroup FTD (n = 9) could be demonstrated. Patients with FTLD showed a significantly lower metabolism in the left frontal lobe and in the left basal ganglia when compared to AD and to MCI. Complementary analyses using statistical parametric mapping (SPM2) supported the findings of the visual analysis. In detecting FTLD with visual rating, sensitivity/specificity was 81/94% compared to AD and 81/64% compared to MCI. Patients with FTD were correctly attributed to a diagnosis of FTLD with a sensitivity of 89%. This visual rating scale may facilitate the differential diagnosis of FTLD in clinical routine.

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Title: A visual [18F]FDG-PET rating scale for the differential diagnosis of frontotemporal lobar degeneration
Authors: Stefan Poljansky
Bernd Ibach
Barbara Hirschberger
Peter Männer
Hans Klünemann
Göran Hajak
Jörg Marienhagen
Publication date: 01-09-2011
Publisher: Springer-Verlag
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 6/2011
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-010-0184-0

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A visual [18F]FDG-PET rating scale for the differential diagnosis of frontotemporal lobar degeneration

Abstract

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