Skip to main content
Top
Published in: European Archives of Oto-Rhino-Laryngology 3/2005

01-03-2005 | Laryngology

Carcinoid tumours of the larynx

Authors: Urmi Bapat, Neil A. MacKinnon, Michael G. Spencer

Published in: European Archives of Oto-Rhino-Laryngology | Issue 3/2005

Login to get access

Abstract

The larynx is a rare site of origin of neuroendocrine carcinomas. They can be divided into typical, atypical and small cell tumours on the basis of their histopathological differentiation. The tumour histology and prognosis correlate closely. The typical carcinoid tumours are well differentiated with a benign course. Conservative surgery for local disease is the treatment and is associated with good survival. The atypical carcinoid tumours are poorly differentiated with an aggressive course. Response to radiotherapy and chemotherapy is poor. The treatment of choice is adequate total excision of the lesion with neck dissection if there is clinical evidence of cervical lymphadenopathy and a careful follow-up so as to recognise and treat any metastatic spread. We present two cases with similar history and clinical findings—one typical and the other atypical—and discuss the relevant literature.
Literature
1.
go back to reference Batsakis JG, El-Naggar AK, Luna MA (1992) Pathology consultation: neuroendocrine tumors of larynx. Ann Otol Rhinol Laryngol 101:710–714PubMed Batsakis JG, El-Naggar AK, Luna MA (1992) Pathology consultation: neuroendocrine tumors of larynx. Ann Otol Rhinol Laryngol 101:710–714PubMed
2.
go back to reference Baugh RF, Wolf GT, Lloyd RV, McClatchey KD, Evans DA (1987) Carcinoid (neuroendocrine carcinoma) of the larynx. Ann Otol Rhinol Laryngol 96:315–321PubMed Baugh RF, Wolf GT, Lloyd RV, McClatchey KD, Evans DA (1987) Carcinoid (neuroendocrine carcinoma) of the larynx. Ann Otol Rhinol Laryngol 96:315–321PubMed
3.
go back to reference Blok PHHM, Manni JJ, van der Broek P, van Haelst UJGM, Slooff JL (1985) Carcinoid of the larynx: a report of three cases and a review of literature. Laryngoscope 95:715–719PubMed Blok PHHM, Manni JJ, van der Broek P, van Haelst UJGM, Slooff JL (1985) Carcinoid of the larynx: a report of three cases and a review of literature. Laryngoscope 95:715–719PubMed
4.
go back to reference Ereno C, Lopez JI, Sanchez JM (1997) Atypical carcinoid of larynx: presentation with scalp metastases. J Laryngol Otol 111:89–91 Ereno C, Lopez JI, Sanchez JM (1997) Atypical carcinoid of larynx: presentation with scalp metastases. J Laryngol Otol 111:89–91
5.
go back to reference Ferlito A, Barnes L, Rinaldo A, Gnepp DR, Milroy CM (1998) A review of neuroendocrine neoplasms of the larynx: Update on diagnosis and treatment. J Laryngol Otol 112:827–834PubMed Ferlito A, Barnes L, Rinaldo A, Gnepp DR, Milroy CM (1998) A review of neuroendocrine neoplasms of the larynx: Update on diagnosis and treatment. J Laryngol Otol 112:827–834PubMed
6.
go back to reference Ferlito A, Friedman I (1989) Review of neuroendocrine carcinomas of the larynx. Ann Otol Rhinol Laryngol 98:780–790PubMed Ferlito A, Friedman I (1989) Review of neuroendocrine carcinomas of the larynx. Ann Otol Rhinol Laryngol 98:780–790PubMed
7.
go back to reference Gnepp DR (1991) Small cell neuroendocrine carcinoma of the larynx. A critical review of the literature. ORL J Otorhinolaryngol Relat Spec 53:210–219PubMed Gnepp DR (1991) Small cell neuroendocrine carcinoma of the larynx. A critical review of the literature. ORL J Otorhinolaryngol Relat Spec 53:210–219PubMed
8.
go back to reference Goldman NC, Hood CI, Singleton GT (1969) Carcinoid of the larynx. Arch Otolaryngol 90:91–93 Goldman NC, Hood CI, Singleton GT (1969) Carcinoid of the larynx. Arch Otolaryngol 90:91–93
9.
go back to reference Hoff M, Kramp B (2000) Neuroendocrine tumors of the larynx (NETL). Laryngorhinootologie 79:573–578CrossRefPubMed Hoff M, Kramp B (2000) Neuroendocrine tumors of the larynx (NETL). Laryngorhinootologie 79:573–578CrossRefPubMed
10.
go back to reference Laccourreye O, Brasnu D, Carnot F, Fichaux P, Laccourreye H (1991) Carcinoid (neuroendocrine) tumor of the arytenoid. Arch Otolaryngol Head Neck Surg 117:1395–1399PubMed Laccourreye O, Brasnu D, Carnot F, Fichaux P, Laccourreye H (1991) Carcinoid (neuroendocrine) tumor of the arytenoid. Arch Otolaryngol Head Neck Surg 117:1395–1399PubMed
11.
go back to reference Logue JP, Banerjee SS, Slevin NJ, Vasanthan S (1991) Neuroendocrine carcinomas of the larynx. J Laryngol Otol 105:1031–1035PubMed Logue JP, Banerjee SS, Slevin NJ, Vasanthan S (1991) Neuroendocrine carcinomas of the larynx. J Laryngol Otol 105:1031–1035PubMed
12.
go back to reference McBride LC, Righi PD, Krakovitz PR (1999) Case study of well differentiated carcinoid tumor of the larynx and review of laryngeal neuroendocrine tumors. Otolaryngol Head Neck Surg 120:536–539CrossRefPubMed McBride LC, Righi PD, Krakovitz PR (1999) Case study of well differentiated carcinoid tumor of the larynx and review of laryngeal neuroendocrine tumors. Otolaryngol Head Neck Surg 120:536–539CrossRefPubMed
13.
go back to reference Overholt SM, Donovan DT, Schwartz MR, Laucirica R, Green LK, Alford BR (1995) Neuroendocrine neoplasms of the larynx. Laryngoscope 105:789–794PubMed Overholt SM, Donovan DT, Schwartz MR, Laucirica R, Green LK, Alford BR (1995) Neuroendocrine neoplasms of the larynx. Laryngoscope 105:789–794PubMed
14.
go back to reference Paladugu RR, Nethwani BN, Goodstein J, Dardo LE, Memoli VE, Gould VE (1982) Carcinoma of the larynx with mucosubstance production and neuroendocrine differentiation: An ultrastructural and immunohistochemical study. Cancer 49:343–349PubMed Paladugu RR, Nethwani BN, Goodstein J, Dardo LE, Memoli VE, Gould VE (1982) Carcinoma of the larynx with mucosubstance production and neuroendocrine differentiation: An ultrastructural and immunohistochemical study. Cancer 49:343–349PubMed
15.
go back to reference Shanmugaratnam K, Sobin LH (1991) Histological typing of tumours of the upper respiratory tract and ear, 2nd edn. Springer, Berlin Heidelberg New York Shanmugaratnam K, Sobin LH (1991) Histological typing of tumours of the upper respiratory tract and ear, 2nd edn. Springer, Berlin Heidelberg New York
16.
go back to reference Soga J, Osaka M, Yakuwa Y (2002) Laryngeal endocrinomas (carcinoids and relevant neoplasms): analysis of 278 reported cases. J Exp Clin Cancer Res 21:5–13PubMed Soga J, Osaka M, Yakuwa Y (2002) Laryngeal endocrinomas (carcinoids and relevant neoplasms): analysis of 278 reported cases. J Exp Clin Cancer Res 21:5–13PubMed
17.
go back to reference Weighill JS, Tankel W, Mene A (1986) Carcinoid tumour of the larynx. J Laryngol Otol 100:1421–1426PubMed Weighill JS, Tankel W, Mene A (1986) Carcinoid tumour of the larynx. J Laryngol Otol 100:1421–1426PubMed
18.
go back to reference Woodruff JM, Senie RT (1991) Atypical carcinoid tumour of the larynx: a critical review of literature. ORL J Otorhinolaryngol Relat Spec 53:194–209PubMed Woodruff JM, Senie RT (1991) Atypical carcinoid tumour of the larynx: a critical review of literature. ORL J Otorhinolaryngol Relat Spec 53:194–209PubMed
Metadata
Title
Carcinoid tumours of the larynx
Authors
Urmi Bapat
Neil A. MacKinnon
Michael G. Spencer
Publication date
01-03-2005
Publisher
Springer-Verlag
Published in
European Archives of Oto-Rhino-Laryngology / Issue 3/2005
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-004-0788-y

Other articles of this Issue 3/2005

European Archives of Oto-Rhino-Laryngology 3/2005 Go to the issue

Letter to the Editors

Reply concerning Botox dosage