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Archives of Gynecology and Obstetrics

Published in:

01-04-2016 | Gynecologic Oncology

Association between serum folate level and cervical cancer: a meta-analysis

Authors: Xinyue Zhou, Yuanguang Meng

Published in: Archives of Gynecology and Obstetrics | Issue 4/2016

Abstract

Purpose

The aim of this study was to evaluate the association between serum folate level and cervical cancer.

Methods

PubMed, Medline, Springer, Elsevier Science Direct, Cochrane Library and Google scholar were searched for relevant trials. Rev.Man5.1 and Stata 11.0 software were applied for this meta-analysis. Odds Ratio (OR) and 95 % confidence intervals (95 % CI) were collected and calculated in a fixed-effects model or a random-effects model when appropriate. Subgroup analysis was performed by sample size, participant’s geographical location and definition of deficient serum folate level.

Results

A total of 6 case–control studies including 2383 participants were included in the meta-analysis. The overall meta-analysis showed that there were significant differences between cases and controls, suggesting that deficient serum folate level was associated with the increased risk of cervical cancer. After stratification subgroup analysis, significant difference was also found in subgroup with sample size <500 as well as in Asian population, but not in subgroup with sample size ≥500, American populations as well as different definition of deficient serum folate level (<6.4 ng/ml or others).

Conclusions

Based on our meta-analysis, deficiency of serum folate level was associated with the increased risk of cervical cancer among Asian populations.

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Title: Association between serum folate level and cervical cancer: a meta-analysis
Authors: Xinyue Zhou
Yuanguang Meng
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 4/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-015-3852-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between serum folate level and cervical cancer: a meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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