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Published in: Archives of Gynecology and Obstetrics 2/2014

01-08-2014 | Review

Amniotic fluid-derived mesenchymal stem cells: characteristics and therapeutic applications

Published in: Archives of Gynecology and Obstetrics | Issue 2/2014

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Abstract

Purpose

Amniotic fluid mesenchymal stem cells (AF-MSCs) are promising candidates for cell-based therapy. This review presents a comprehensive overview of the features and therapeutic applications of these cells.

Methods

This is a literature review combined with experience of practice.

Conclusion

Although the long-term risks of AF-MSCs require further investigation, these cells are increasing in popularity in the fields of regenerative medicine and targeting therapy because of their unique properties.
Literature
1.
go back to reference Kang NH, Hwang KA, Kim SU, Kim YB, Hyun SH, Jeung EB, Choi KC (2012) Potential antitumor therapeutic strategies of human amniotic membrane and amniotic fluid-derived stem cells. Cancer Gene Ther 19(8):517–522. doi:10.1038/cgt.2012.30 PubMedCrossRef Kang NH, Hwang KA, Kim SU, Kim YB, Hyun SH, Jeung EB, Choi KC (2012) Potential antitumor therapeutic strategies of human amniotic membrane and amniotic fluid-derived stem cells. Cancer Gene Ther 19(8):517–522. doi:10.​1038/​cgt.​2012.​30 PubMedCrossRef
2.
go back to reference Bitsika V, Roubelakis MG, Zagoura D, Trohatou O, Makridakis M, Pappa KI, Marini FC, Vlahou A, Anagnou NP (2012) Human amniotic fluid-derived mesenchymal stem cells as therapeutic vehicles: a novel approach for the treatment of bladder cancer. Stem Cells Dev 21(7):1097–1111. doi:10.1089/scd.2011.0151 PubMedCrossRef Bitsika V, Roubelakis MG, Zagoura D, Trohatou O, Makridakis M, Pappa KI, Marini FC, Vlahou A, Anagnou NP (2012) Human amniotic fluid-derived mesenchymal stem cells as therapeutic vehicles: a novel approach for the treatment of bladder cancer. Stem Cells Dev 21(7):1097–1111. doi:10.​1089/​scd.​2011.​0151 PubMedCrossRef
3.
go back to reference Ferroni L, Gardin C, Tocco I, Epis R, Casadei A, Vindigni V, Mucci G, Zavan B (2012) Potential for neural differentiation of mesenchymal stem cells. Adv Biochem Eng Biotechnol. doi:10.1007/10_2012_152 Ferroni L, Gardin C, Tocco I, Epis R, Casadei A, Vindigni V, Mucci G, Zavan B (2012) Potential for neural differentiation of mesenchymal stem cells. Adv Biochem Eng Biotechnol. doi:10.​1007/​10_​2012_​152
5.
go back to reference Marappagounder D, Somasundaram I, Janvikula RS, Dorairaj S (2012) Long-term culture optimization of human omentum fat-derived mesenchymal stem cells. Cell Biol Int 36(11):1029–1036. doi:10.1042/CBI20120201 PubMedCrossRef Marappagounder D, Somasundaram I, Janvikula RS, Dorairaj S (2012) Long-term culture optimization of human omentum fat-derived mesenchymal stem cells. Cell Biol Int 36(11):1029–1036. doi:10.​1042/​CBI20120201 PubMedCrossRef
6.
go back to reference Tsai MS, Lee JL, Chang YJ, Hwang SM (2004) Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol. Hum Reprod 19(6):1450–1456. doi:10.1093/humrep/deh279 PubMedCrossRef Tsai MS, Lee JL, Chang YJ, Hwang SM (2004) Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol. Hum Reprod 19(6):1450–1456. doi:10.​1093/​humrep/​deh279 PubMedCrossRef
7.
go back to reference Antonucci I, Stuppia L, Kaneko Y, Yu S, Tajiri N, Bae EC, Chheda SH, Weinbren NL, Borlongan CV (2011) Amniotic fluid as a rich source of mesenchymal stromal cells for transplantation therapy. Cell Transplant 20(6):789–795. doi:10.3727/096368910X539074 PubMedCrossRef Antonucci I, Stuppia L, Kaneko Y, Yu S, Tajiri N, Bae EC, Chheda SH, Weinbren NL, Borlongan CV (2011) Amniotic fluid as a rich source of mesenchymal stromal cells for transplantation therapy. Cell Transplant 20(6):789–795. doi:10.​3727/​096368910X539074​ PubMedCrossRef
8.
go back to reference Kim J, Lee Y, Kim H, Hwang KJ, Kwon HC, Kim SK, Cho DJ, Kang SG, You J (2007) Human amniotic fluid-derived stem cells have characteristics of multipotent stem cells. Cell Prolif 40:75–90PubMedCrossRef Kim J, Lee Y, Kim H, Hwang KJ, Kwon HC, Kim SK, Cho DJ, Kang SG, You J (2007) Human amniotic fluid-derived stem cells have characteristics of multipotent stem cells. Cell Prolif 40:75–90PubMedCrossRef
9.
go back to reference Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, Cazzanti F, Risso M, Gualandi F, Mancardi GL, Pistoia V, Uccelli A (2006) Human mesenchymal stem cells modulate B-cell functions. Blood 107(1):367–372. doi:10.1182/blood-2005-07-2657 PubMedCrossRef Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, Cazzanti F, Risso M, Gualandi F, Mancardi GL, Pistoia V, Uccelli A (2006) Human mesenchymal stem cells modulate B-cell functions. Blood 107(1):367–372. doi:10.​1182/​blood-2005-07-2657 PubMedCrossRef
13.
go back to reference De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A (2007) Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol 25(1):100–106. doi:10.1038/nbt1274 PubMedCrossRef De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A (2007) Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol 25(1):100–106. doi:10.​1038/​nbt1274 PubMedCrossRef
14.
go back to reference In’t Anker PS, Scherjon SA, Kleijburg-van der Keur C, de Groot-Swings GM, Claas FH, Fibbe WE, Kanhai HH (2004) Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells 22(7):1338–1345. doi:10.1634/stemcells.2004-0058 CrossRef In’t Anker PS, Scherjon SA, Kleijburg-van der Keur C, de Groot-Swings GM, Claas FH, Fibbe WE, Kanhai HH (2004) Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells 22(7):1338–1345. doi:10.​1634/​stemcells.​2004-0058 CrossRef
15.
go back to reference Mauro A, Turriani M, Ioannoni A, Russo V, Martelli A, Di Giacinto O, Nardinocchi D, Berardinelli P (2010) Isolation, characterization, and in vitro differentiation of ovine amniotic stem cells. Vet Res Commun 34(Suppl 1):S25–S28. doi:10.1007/s11259-010-9393-2 PubMedCrossRef Mauro A, Turriani M, Ioannoni A, Russo V, Martelli A, Di Giacinto O, Nardinocchi D, Berardinelli P (2010) Isolation, characterization, and in vitro differentiation of ovine amniotic stem cells. Vet Res Commun 34(Suppl 1):S25–S28. doi:10.​1007/​s11259-010-9393-2 PubMedCrossRef
16.
go back to reference Pesce M, Schöler HR (2001) Oct-4—gatekeeper in the beginnings of mammalian development. Stem Cells 19:271–278PubMedCrossRef Pesce M, Schöler HR (2001) Oct-4—gatekeeper in the beginnings of mammalian development. Stem Cells 19:271–278PubMedCrossRef
17.
go back to reference Cananzi M, Atala A, De Coppi P (2009) Stem cells derived from amniotic fluid—new potentials in regenerative medicine. Ethics Biosci Life 4(1):17–27 Cananzi M, Atala A, De Coppi P (2009) Stem cells derived from amniotic fluid—new potentials in regenerative medicine. Ethics Biosci Life 4(1):17–27
19.
go back to reference Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8(4):315–317. doi:10.1080/14653240600855905 PubMedCrossRef Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8(4):315–317. doi:10.​1080/​1465324060085590​5 PubMedCrossRef
21.
go back to reference Bai J, Hu Y, Wang YR, Liu LF, Chen J, Su SP, Wang Y (2012) Comparison of human amniotic fluid-derived and umbilical cord Wharton’s jelly-derived mesenchymal stromal cells: characterization and myocardial differentiation capacity. J Geriatr Cardiol JGC 9(2):166–171. doi:10.3724/SP.J.1263.2011.12091 CrossRef Bai J, Hu Y, Wang YR, Liu LF, Chen J, Su SP, Wang Y (2012) Comparison of human amniotic fluid-derived and umbilical cord Wharton’s jelly-derived mesenchymal stromal cells: characterization and myocardial differentiation capacity. J Geriatr Cardiol JGC 9(2):166–171. doi:10.​3724/​SP.​J.​1263.​2011.​12091 CrossRef
22.
go back to reference HU Jie YANG Li-Juan, LIU Hui, WANG Yun-Fang (2009) Fractional cultivation, identification and immunosuppression of amniotic fluid-derived human mesenchymal stem cells. Bull Acad Mil Med Sci 33(2) HU Jie YANG Li-Juan, LIU Hui, WANG Yun-Fang (2009) Fractional cultivation, identification and immunosuppression of amniotic fluid-derived human mesenchymal stem cells. Bull Acad Mil Med Sci 33(2)
23.
go back to reference Tolar J, Nauta AJ, Osborn MJ, Panoskaltsis Mortari A, McElmurry RT, Bell S, Xia L, Zhou N, Riddle M, Schroeder TM, Westendorf JJ, McIvor RS, Hogendoorn PC, Szuhai K, Oseth L, Hirsch B, Yant SR, Kay MA, Peister A, Prockop DJ, Fibbe WE, Blazar BR (2007) Sarcoma derived from cultured mesenchymal stem cells. Stem Cells 25(2):371–379. doi:10.1634/stemcells.2005-0620 PubMedCrossRef Tolar J, Nauta AJ, Osborn MJ, Panoskaltsis Mortari A, McElmurry RT, Bell S, Xia L, Zhou N, Riddle M, Schroeder TM, Westendorf JJ, McIvor RS, Hogendoorn PC, Szuhai K, Oseth L, Hirsch B, Yant SR, Kay MA, Peister A, Prockop DJ, Fibbe WE, Blazar BR (2007) Sarcoma derived from cultured mesenchymal stem cells. Stem Cells 25(2):371–379. doi:10.​1634/​stemcells.​2005-0620 PubMedCrossRef
24.
go back to reference Wang Y, Bai J, Chen J, Liu L, Wang Y (2012) Comparative studies on different cryopreservation protocols of human amniotic fluid-derived mesenchymal stem cells. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chin J Reparative Reconstr Surg 26(2):141–145 Wang Y, Bai J, Chen J, Liu L, Wang Y (2012) Comparative studies on different cryopreservation protocols of human amniotic fluid-derived mesenchymal stem cells. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chin J Reparative Reconstr Surg 26(2):141–145
25.
go back to reference Carraro G, Perin L, Sedrakyan S, Giuliani S, Tiozzo C, Lee J, Turcatel G, De Langhe SP, Driscoll B, Bellusci S, Minoo P, Atala A, De Filippo RE, Warburton D (2008) Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells 26(11):2902–2911. doi:10.1634/stemcells.2008-0090 PubMedCentralPubMedCrossRef Carraro G, Perin L, Sedrakyan S, Giuliani S, Tiozzo C, Lee J, Turcatel G, De Langhe SP, Driscoll B, Bellusci S, Minoo P, Atala A, De Filippo RE, Warburton D (2008) Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells 26(11):2902–2911. doi:10.​1634/​stemcells.​2008-0090 PubMedCentralPubMedCrossRef
27.
go back to reference Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L (2008) Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2. Blood 111(3):1327–1333. doi:10.1182/blood-2007-02-074997 PubMedCrossRef Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L (2008) Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2. Blood 111(3):1327–1333. doi:10.​1182/​blood-2007-02-074997 PubMedCrossRef
29.
go back to reference Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, Lanino E, Sundberg B, Bernardo ME, Remberger M, Dini G, Egeler RM, Bacigalupo A, Fibbe W, Ringdén O (2008) Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 371(9624):1579–1586. doi:10.1016/s0140-6736(08)60690-x PubMedCrossRef Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, Lanino E, Sundberg B, Bernardo ME, Remberger M, Dini G, Egeler RM, Bacigalupo A, Fibbe W, Ringdén O (2008) Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 371(9624):1579–1586. doi:10.​1016/​s0140-6736(08)60690-x PubMedCrossRef
31.
go back to reference Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, Wang S, Morton CC, McMahon AP, Powers D, Melton DA (2004) Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med 350(13):1353–1356. doi:10.1056/NEJMsr040330 PubMedCrossRef Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, Wang S, Morton CC, McMahon AP, Powers D, Melton DA (2004) Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med 350(13):1353–1356. doi:10.​1056/​NEJMsr040330 PubMedCrossRef
32.
go back to reference Amit M, Carpenter MK, Inokuma MS, Chiu CP, Harris CP, Waknitz MA, Itskovitz-Eldor J, Thomson JA (2000) Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev Biol 227(2):271–278. doi:10.1006/dbio.2000.9912 PubMedCrossRef Amit M, Carpenter MK, Inokuma MS, Chiu CP, Harris CP, Waknitz MA, Itskovitz-Eldor J, Thomson JA (2000) Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev Biol 227(2):271–278. doi:10.​1006/​dbio.​2000.​9912 PubMedCrossRef
33.
go back to reference Aguilar S (2007) Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung. Stem Cells 25(1586–1594):2006 10.1634/stemcells-0762 Aguilar S (2007) Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung. Stem Cells 25(1586–1594):2006 10.1634/stemcells-0762
34.
go back to reference Zimmermann S, Voss M, Kaiser S, Kapp U, Waller CF, Martens UM (2003) Lack of telomerase activity in human mesenchymal stem cells. Leuk Off J Leuk Soc Am Leuk Res Fund UK 17(6):1146–1149. doi:10.1038/sj.leu.2402962 CrossRef Zimmermann S, Voss M, Kaiser S, Kapp U, Waller CF, Martens UM (2003) Lack of telomerase activity in human mesenchymal stem cells. Leuk Off J Leuk Soc Am Leuk Res Fund UK 17(6):1146–1149. doi:10.​1038/​sj.​leu.​2402962 CrossRef
35.
36.
go back to reference Sessarego N, Parodi A, Podesta M, Benvenuto F, Mogni M, Raviolo V, Lituania M, Kunkl A, Ferlazzo G, Bricarelli FD, Uccelli A, Frassoni F (2008) Multipotent mesenchymal stromal cells from amniotic fluid: solid perspectives for clinical application. Haematologica 93(3):339–346. doi:10.3324/haematol.11869 PubMedCrossRef Sessarego N, Parodi A, Podesta M, Benvenuto F, Mogni M, Raviolo V, Lituania M, Kunkl A, Ferlazzo G, Bricarelli FD, Uccelli A, Frassoni F (2008) Multipotent mesenchymal stromal cells from amniotic fluid: solid perspectives for clinical application. Haematologica 93(3):339–346. doi:10.​3324/​haematol.​11869 PubMedCrossRef
37.
go back to reference Moschidou D, Mukherjee S, Blundell MP, Drews K, Jones GN, Abdulrazzak H et al (2012) Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach. Mol Ther 20:1953–1967 Moschidou D, Mukherjee S, Blundell MP, Drews K, Jones GN, Abdulrazzak H et al (2012) Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach. Mol Ther 20:1953–1967
39.
go back to reference Kunter U, Rong S, Boor P, Eitner F, Muller-Newen G, Djuric Z, van Roeyen CR, Konieczny A, Ostendorf T, Villa L, Milovanceva-Popovska M, Kerjaschki D, Floege J (2007) Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes. J Am Soc Nephrol JASN 18(6):1754–1764. doi:10.1681/ASN.2007010044 CrossRef Kunter U, Rong S, Boor P, Eitner F, Muller-Newen G, Djuric Z, van Roeyen CR, Konieczny A, Ostendorf T, Villa L, Milovanceva-Popovska M, Kerjaschki D, Floege J (2007) Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes. J Am Soc Nephrol JASN 18(6):1754–1764. doi:10.​1681/​ASN.​2007010044 CrossRef
40.
go back to reference Chiavegato A, Bollini S, Pozzobon M, Callegari A, Gasparotto L, Taiani J, Piccoli M, Lenzini E, Gerosa G, Vendramin I, Cozzi E, Angelini A, Iop L, Zanon GF, Atala A, De Coppi P, Sartore S (2007) Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat. J Mol Cell Cardiol 42(4):746–759. doi:10.1016/j.yjmcc.2006.12.008 PubMedCrossRef Chiavegato A, Bollini S, Pozzobon M, Callegari A, Gasparotto L, Taiani J, Piccoli M, Lenzini E, Gerosa G, Vendramin I, Cozzi E, Angelini A, Iop L, Zanon GF, Atala A, De Coppi P, Sartore S (2007) Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat. J Mol Cell Cardiol 42(4):746–759. doi:10.​1016/​j.​yjmcc.​2006.​12.​008 PubMedCrossRef
41.
go back to reference Weber B, Emmert MY, Behr L, Schoenauer R, Brokopp C, Drogemuller C, Modregger P, Stampanoni M, Vats D, Rudin M, Burzle W, Farine M, Mazza E, Frauenfelder T, Zannettino AC, Zund G, Kretschmar O, Falk V, Hoerstrup SP (2012) Prenatally engineered autologous amniotic fluid stem cell-based heart valves in the fetal circulation. Biomaterials 33(16):4031–4043. doi:10.1016/j.biomaterials.2011.11.087 PubMedCrossRef Weber B, Emmert MY, Behr L, Schoenauer R, Brokopp C, Drogemuller C, Modregger P, Stampanoni M, Vats D, Rudin M, Burzle W, Farine M, Mazza E, Frauenfelder T, Zannettino AC, Zund G, Kretschmar O, Falk V, Hoerstrup SP (2012) Prenatally engineered autologous amniotic fluid stem cell-based heart valves in the fetal circulation. Biomaterials 33(16):4031–4043. doi:10.​1016/​j.​biomaterials.​2011.​11.​087 PubMedCrossRef
42.
go back to reference SHAUN M.Kunisaki DAF (2006) Fetal tracheal reconstruction with cartilaginous grafts engineered from mesenchymal amniocytes. Journal oF Pediatric Surgery 41:675-682 SHAUN M.Kunisaki DAF (2006) Fetal tracheal reconstruction with cartilaginous grafts engineered from mesenchymal amniocytes. Journal oF Pediatric Surgery 41:675-682
44.
go back to reference Delo DM, Guan X, Wang Z, Groban L, Callahan M, Smith T, Sane DC, Payne RM, Atala A, Soker S (2011) Calcification after myocardial infarction is independent of amniotic fluid stem cell injection. Cardiovasc Pathol Off J Soc Cardiovasc Pathol 20(2):e69–e78. doi:10.1016/j.carpath.2010.03.001 CrossRef Delo DM, Guan X, Wang Z, Groban L, Callahan M, Smith T, Sane DC, Payne RM, Atala A, Soker S (2011) Calcification after myocardial infarction is independent of amniotic fluid stem cell injection. Cardiovasc Pathol Off J Soc Cardiovasc Pathol 20(2):e69–e78. doi:10.​1016/​j.​carpath.​2010.​03.​001 CrossRef
45.
go back to reference De Coppi P, Callegari A, Chiavegato A, Gasparotto L, Piccoli M, Taiani J, Pozzobon M, Boldrin L, Okabe M, Cozzi E, Atala A, Gamba P, Sartore S (2007) Amniotic fluid and bone marrow derived mesenchymal stem cells can be converted to smooth muscle cells in the cryo-injured rat bladder and prevent compensatory hypertrophy of surviving smooth muscle cells. J Urol 177(1):369–376. doi:10.1016/j.juro.2006.09.103 PubMedCrossRef De Coppi P, Callegari A, Chiavegato A, Gasparotto L, Piccoli M, Taiani J, Pozzobon M, Boldrin L, Okabe M, Cozzi E, Atala A, Gamba P, Sartore S (2007) Amniotic fluid and bone marrow derived mesenchymal stem cells can be converted to smooth muscle cells in the cryo-injured rat bladder and prevent compensatory hypertrophy of surviving smooth muscle cells. J Urol 177(1):369–376. doi:10.​1016/​j.​juro.​2006.​09.​103 PubMedCrossRef
47.
go back to reference Cananzi M, De Coppi P (2012) CD117+ amniotic fluid stem cells: state of the art and future perspectives. Organogenesis 8(3):77–88. doi:10.4161/org.22426 Cananzi M, De Coppi P (2012) CD117+ amniotic fluid stem cells: state of the art and future perspectives. Organogenesis 8(3):77–88. doi:10.​4161/​org.​22426
49.
go back to reference Gran SED (1996) Why do so many cancer patients fail to respond to interferon therapy. J Interferon Cytokine Res 16:275–281CrossRef Gran SED (1996) Why do so many cancer patients fail to respond to interferon therapy. J Interferon Cytokine Res 16:275–281CrossRef
51.
go back to reference Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W, Small JE, Herrlinger U, Ourednik V, Black PM, Breakefield XO, Snyder EY (2000) Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 97(23):12846–12851. doi:10.1073/pnas.97.23.12846 PubMedCentralPubMedCrossRef Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W, Small JE, Herrlinger U, Ourednik V, Black PM, Breakefield XO, Snyder EY (2000) Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 97(23):12846–12851. doi:10.​1073/​pnas.​97.​23.​12846 PubMedCentralPubMedCrossRef
52.
53.
go back to reference Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, Chen J, Hentschel S, Vecil G, Dembinski J, Andreeff M, Lang FF (2005) Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 65(8):3307–3318PubMed Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, Chen J, Hentschel S, Vecil G, Dembinski J, Andreeff M, Lang FF (2005) Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 65(8):3307–3318PubMed
54.
go back to reference Khakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira II, Nguyen AT, Malide D, Combs CA, Hall G, Zhang J, Raffeld M, Rogers TB, Stetler-Stevenson W, Frank JA, Reitz M, Finkel T (2006) Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi’s sarcoma. J Exp Med 203(5):1235–1247. doi:10.1084/jem.20051921 PubMedCentralPubMedCrossRef Khakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira II, Nguyen AT, Malide D, Combs CA, Hall G, Zhang J, Raffeld M, Rogers TB, Stetler-Stevenson W, Frank JA, Reitz M, Finkel T (2006) Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi’s sarcoma. J Exp Med 203(5):1235–1247. doi:10.​1084/​jem.​20051921 PubMedCentralPubMedCrossRef
55.
go back to reference Hung SC, Deng WP, Yang WK, Liu RS, Lee CC, Su TC, Lin RJ, Yang DM, Chang CW, Chen WH, Wei HJ, Gelovani JG (2005) Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging. Clin Cancer Res Off J Am Assoc Cancer Res 11(21):7749–7756. doi:10.1158/1078-0432.CCR-05-0876 CrossRef Hung SC, Deng WP, Yang WK, Liu RS, Lee CC, Su TC, Lin RJ, Yang DM, Chang CW, Chen WH, Wei HJ, Gelovani JG (2005) Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging. Clin Cancer Res Off J Am Assoc Cancer Res 11(21):7749–7756. doi:10.​1158/​1078-0432.​CCR-05-0876 CrossRef
56.
go back to reference Lee K, Majumdar MK, Buyaner D, Hendricks JK, Pittenger MF, Mosca JD (2001) Human mesenchymal stem cells maintain transgene expression during expansion and differentiation. Mol Ther J Am Soc Gene Ther 3(6):857–866. doi:10.1006/mthe.2001.0327 CrossRef Lee K, Majumdar MK, Buyaner D, Hendricks JK, Pittenger MF, Mosca JD (2001) Human mesenchymal stem cells maintain transgene expression during expansion and differentiation. Mol Ther J Am Soc Gene Ther 3(6):857–866. doi:10.​1006/​mthe.​2001.​0327 CrossRef
57.
go back to reference Gutova M, Najbauer J, Frank RT, Kendall SE, Gevorgyan A, Metz MZ, Guevorkian M, Edmiston M, Zhao D, Glackin CA, Kim SU, Aboody KS (2008) Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors. Stem Cells 26(6):1406–1413. doi:10.1634/stemcells.2008-0141 PubMedCrossRef Gutova M, Najbauer J, Frank RT, Kendall SE, Gevorgyan A, Metz MZ, Guevorkian M, Edmiston M, Zhao D, Glackin CA, Kim SU, Aboody KS (2008) Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors. Stem Cells 26(6):1406–1413. doi:10.​1634/​stemcells.​2008-0141 PubMedCrossRef
58.
go back to reference Menon LG, Picinich S, Koneru R, Gao H, Lin SY, Koneru M, Mayer-Kuckuk P, Glod J, Banerjee D (2007) Differential gene expression associated with migration of mesenchymal stem cells to conditioned medium from tumor cells or bone marrow cells. Stem Cells 25(2):520–528. doi:10.1634/stemcells.2006-0257 PubMedCrossRef Menon LG, Picinich S, Koneru R, Gao H, Lin SY, Koneru M, Mayer-Kuckuk P, Glod J, Banerjee D (2007) Differential gene expression associated with migration of mesenchymal stem cells to conditioned medium from tumor cells or bone marrow cells. Stem Cells 25(2):520–528. doi:10.​1634/​stemcells.​2006-0257 PubMedCrossRef
59.
go back to reference Kidd S, Caldwell L, Dietrich M, Samudio I, Spaeth EL, Watson K, Shi Y, Abbruzzese J, Konopleva M, Andreeff M, Marini FC (2010) Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment. Cytotherapy 12(5):615–625. doi:10.3109/14653241003631815 PubMedCrossRef Kidd S, Caldwell L, Dietrich M, Samudio I, Spaeth EL, Watson K, Shi Y, Abbruzzese J, Konopleva M, Andreeff M, Marini FC (2010) Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment. Cytotherapy 12(5):615–625. doi:10.​3109/​1465324100363181​5 PubMedCrossRef
60.
go back to reference Cho JA, Park H, Kim HK, Lim EH, Seo SW, Choi JS, Lee KW (2009) Hyperthermia-treated mesenchymal stem cells exert antitumor effects on human carcinoma cell line. Cancer 115(2):311–323. doi:10.1002/cncr.24032 PubMedCrossRef Cho JA, Park H, Kim HK, Lim EH, Seo SW, Choi JS, Lee KW (2009) Hyperthermia-treated mesenchymal stem cells exert antitumor effects on human carcinoma cell line. Cancer 115(2):311–323. doi:10.​1002/​cncr.​24032 PubMedCrossRef
61.
go back to reference Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449(7162):557–563. doi:10.1038/nature06188 PubMedCrossRef Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449(7162):557–563. doi:10.​1038/​nature06188 PubMedCrossRef
Metadata
Title
Amniotic fluid-derived mesenchymal stem cells: characteristics and therapeutic applications
Publication date
01-08-2014
Published in
Archives of Gynecology and Obstetrics / Issue 2/2014
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-014-3231-7

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