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01-08-2012 | Maternal-Fetal Medicine

Cancer during pregnancy: perinatal outcome after in utero exposure to chemotherapy

Authors: El-Said Abdel-Hady, Reda Abdel-Hady Hemida, Anas Gamal, Maha El-Zafarany, Eman Toson, Mohammed Attia El-Bayoumi

Published in: Archives of Gynecology and Obstetrics | Issue 2/2012

Abstract

Objectives

To study the outcome of pregnancies complicated by malignant disease, in particular neonatal morbidity and mortality after in utero exposure to chemotherapy.

Methods

This prospective study included 118 patients diagnosed with malignant disease for the first time during pregnancy over an 8-year period (March 2003–March 2011). Outcome of neonates born to mothers who received chemotherapy during pregnancy was studied and compared with a control group.

Results

The commonest cancer type diagnosed during pregnancy (56/118 = 47.45 %) was breast carcinoma followed by lymphoma/leukemia (32 = 27.12 %). Gynecological tumors (all ovarian) represented 10.16 %, soft tissue tumors 5.08 %, colorectal 4.23 %, thyroid 2.54 % and others 3.38 %.

Sixty-one (51.64 %) women received chemotherapy (average 3 ± 2 cycles) during the second and third trimesters. The incidence of neonatal survival, preterm birth, small for gestational age and congenital malformations was not significantly different between women who received chemotherapy during pregnancy and the control group. Five (4.23 %) women with advanced disease died during or shortly after termination of pregnancy.

Conclusion

In utero exposure to chemotherapy during the second and third trimesters of pregnancy carries minimal morbidity to the unborn fetus.

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Title: Cancer during pregnancy: perinatal outcome after in utero exposure to chemotherapy
Authors: El-Said Abdel-Hady
Reda Abdel-Hady Hemida
Anas Gamal
Maha El-Zafarany
Eman Toson
Mohammed Attia El-Bayoumi
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 2/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2287-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cancer during pregnancy: perinatal outcome after in utero exposure to chemotherapy

Abstract

Objectives

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

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