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01-04-2015 | Original Paper

IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II–III diffuse gliomas

Authors: Adriana Olar, Khalida M. Wani, Kristin D. Alfaro-Munoz, Lindsey E. Heathcock, Hinke F. van Thuijl, Mark R. Gilbert, Terri S. Armstrong, Erik P. Sulman, Daniel P. Cahill, Elizabeth Vera-Bolanos, Ying Yuan, Jaap C. Reijneveld, Bauke Ylstra, Pieter Wesseling, Kenneth D. Aldape

Published in: Acta Neuropathologica | Issue 4/2015

Abstract

Diffuse gliomas are up till now graded based upon morphology. Recent findings indicate that isocitrate dehydrogenase (IDH) mutation status defines biologically distinct groups of tumors. The role of tumor grade and mitotic index in patient outcome has not been evaluated following stratification by IDH mutation status. To address this, we interrogated 558 WHO grade II–III diffuse gliomas for IDH1/2 mutations and investigated the prognostic impact of WHO grade within IDH-mutant and IDH-wild type tumor subsets independently. The prognostic impact of grade was modest in IDH-mutant [hazard ratio (HR) = 1.21, 95 % confidence interval (CI) = 0.91–1.61] compared to IDH-wild type tumors (HR = 1.74, 95 % CI = 0.95–3.16). Using a dichotomized mitotic index cut-off of 4/1000 tumor cells, we found that while mitotic index was significantly associated with outcome in IDH-wild type tumors (log-rank p < 0.0001, HR = 4.41, 95 % CI = 2.55–7.63), it was not associated with outcome in IDH-mutant tumors (log-rank p = 0.5157, HR = 1.10, 95 % CI = 0.80–1.51), and could demonstrate a statistical interaction (p < 0.0001) between IDH mutation and mitotic index (i.e., suggesting that the effect of mitotic index on patient outcome is dependent on IDH mutation status). Patient age, an established prognostic factor in diffuse glioma, was significantly associated with outcome only in the IDH-wild type subset, and consistent with prior data, 1p/19q co-deletion conferred improved outcome in the IDH-mutant cohort. These findings suggest that stratification of grade II–III gliomas into subsets defined by the presence or absence of IDH mutation leads to subgroups with distinct prognostic characteristics. Further evaluation of grading criteria and prognostic markers is warranted within IDH-mutant versus IDH-wild type diffuse grade II–III gliomas as independent entities.

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Title: IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II–III diffuse gliomas
Authors: Adriana Olar
Khalida M. Wani
Kristin D. Alfaro-Munoz
Lindsey E. Heathcock
Hinke F. van Thuijl
Mark R. Gilbert
Terri S. Armstrong
Erik P. Sulman
Daniel P. Cahill
Elizabeth Vera-Bolanos
Ying Yuan
Jaap C. Reijneveld
Bauke Ylstra
Pieter Wesseling
Kenneth D. Aldape
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 4/2015
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-015-1398-z

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IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II–III diffuse gliomas

Abstract

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Abstract

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