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Acta Neuropathologica
Published in: Acta Neuropathologica 4/2003

01-10-2003 | Editorial Note

Age-associated prevalence and risk factors of Lewy body pathology in a general population

Author: Kurt A. Jellinger

Published in: Acta Neuropathologica | Issue 4/2003

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Excerpt

In a community-based study, Wakisaka et al. [6], examining 102 consecutive autopsy cases, reported Lewy body (LB) pathology in 22.5%, and in 41.4% of demented patients who represented 28.4% of the total. The LB score was not significantly different between cases of dementia with LB (DLB) and non-demented subjects with LB pathology, while the Braak stages were significantly higher in demented cases. Prevalence of LB pathology increased with age. DLB cases with severe Alzheimer (AD) pathology showed increased LB score, and had poorer prognosis than those without AD changes. These data suggest that aging and severe AD pathology have a strong effect on the evolution of LB pathology. …
Literature
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DeLucia MW, Cookson N, Dickson DW (2002) Synuclein-immunoreactive Lewy bodies are detected in the amygdala in less than 20% of Alzheimer's disease (AD) cases. J Neuropathol Exp Neurol 61:454
2.
Jellinger KA, Seppi K, Wenning GK, Poewe W (2002) Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease. J Neural Transm 109:329–339PubMed
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Jellinger KA (2003) Prevalence of vascular lesions in dementia with Lewy Bodies. A postmortem study. J Neural Transm 110:771–778PubMed
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Jellinger KA (2003) Alpha-synuclein pathology in Parkinson's and Alzheimer's disease brain: incidence and topographic distribution—a pilot study. Acta Neuropathol 106:DOI 10.1007/s00401-003-0725-y (published online 5 July 2003)
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Mikolaenko L, Kwan CH, O'Brien R, Petnikov O, Troncoso JC (2003) Abstracts of the 6th International Conference on AD/PD, Sevilla, Spain, p 133
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Wakisaka Y, Furuta A, Tanizaki Y, Kiyohara Y, Iida M, Iwaki T (2003) Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study. Acta Neuropathol DOI 10.1007/s00401-003-0750-x
Metadata
Title
Age-associated prevalence and risk factors of Lewy body pathology in a general population
Author
Kurt A. Jellinger
Publication date
01-10-2003
Publisher
Springer-Verlag
Published in
Acta Neuropathologica / Issue 4/2003
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-003-0751-9

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