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Published in: Basic Research in Cardiology 4/2013

Open Access 01-07-2013 | Invited Review

How can we cure a heart “in flame”? A translational view on inflammation in heart failure

Authors: Ulrich Hofmann, Stefan Frantz

Published in: Basic Research in Cardiology | Issue 4/2013

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Abstract

The prevalence of chronic heart failure is still increasing making it a major health issue in the 21st century. Tremendous evidence has emerged over the past decades that heart failure is associated with a wide array of mechanisms subsumed under the term “inflammation”. Based on the great success of immuno-suppressive treatments in auto-immunity and transplantation, clinical trials were launched targeting inflammatory mediators in patients with chronic heart failure. However, they widely lacked positive outcomes. The failure of the initial study program directed against tumor necrosis factor-α led to the search for alternative therapeutic targets involving a broader spectrum of mechanisms besides cytokines. We here provide an overview of the current knowledge on immune activation in chronic heart failure of different etiologies, summarize clinical studies in the field, address unresolved key questions, and highlight some promising novel therapeutic targets for clinical trials from a translational basic science and clinical perspective.
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Metadata
Title
How can we cure a heart “in flame”? A translational view on inflammation in heart failure
Authors
Ulrich Hofmann
Stefan Frantz
Publication date
01-07-2013
Publisher
Springer Berlin Heidelberg
Published in
Basic Research in Cardiology / Issue 4/2013
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI
https://doi.org/10.1007/s00395-013-0356-y

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