Top

20-04-2024 | Original Contribution

Sex difference in the association of dietary fiber intake with visceral fat volume in Japanese adults

Authors: Maki Igarashi, Motoki Iwasaki, Ryoko Katagiri, Shoichiro Tsugane, Nozomu Kobayashi, Taiki Yamaji

Published in: European Journal of Nutrition

Abstract

Purpose

Dietary fiber is a possible nutritional component which aids in the prevention of visceral fat accumulation. We examined the association between dietary fiber intake and visceral fat volume (VFV) by sex, and further analysed the association by major food sources of dietary fiber.

Methods

In this cross-sectional study, we measured VFV in 2779 Japanese (1564 men and 1215 women) aged 40–89 who underwent positron emission tomography/computed tomography for cancer screening between 2004 and 2005. Dietary fiber intake was calculated based on a validated semi-quantitative food frequency questionnaire. The association between dietary fiber intake and VFV was investigated using multivariate linear regression models after adjustment for potential confounders.

Results

Total, soluble, and insoluble fiber intakes were inversely associated with VFV in men (Q1: 3740 cm³, Q4: 3517 cm³, P_trend: 0.0006 for total fiber), but not in women (Q1: 2207 cm³, Q4: 2193 cm³,P_trend: 0.88 for total fiber). Statistically significant sex difference was observed (P_interaction = 0.001 for total fiber). Subgroup analyses by major food sources revealed that dietary fiber intakes from beans, vegetables and fruits showed an inverse association with VFV in men, while cereal fiber intake showed a tendency toward a positive association in both sexes (Q1: 3520 cm³, Q4: 3671 cm³, P_trend: 0.05 in men, Q1: 2147 cm³, Q4: 2227 cm³, P_trend: 0.10 in women).

Conclusion

We observed a sex-specific association between dietary fiber intake and VFV in Japanese adults. This study suggests that efforts against visceral fat accumulation should take account of the source of dietary fiber.

Available only for authorised users

Silveira EA, Kliemann N, Noll M, Sarrafzadegan N, de Oliveira C (2021) Visceral obesity and incident cancer and cardiovascular disease: an integrative review of the epidemiological evidence. Obes Rev 22:e13088. https://doi.org/10.1111/obr.13088CrossRefPubMed

Neeland IJ, Turer AT, Ayers CR, Powell-Wiley TM, Vega GL, Farzaneh-Far R et al (2012) Dysfunctional adiposity and the risk of Prediabetes and Type 2 diabetes in obese adults. JAMA 308:1150–1159. https://doi.org/10.1001/2012.jama.11132CrossRefPubMedPubMedCentral

Vaughn AC, Cooper EM, DiLorenzo PM, O’Loughlin LJ, Konkel ME, Peters JH et al (2017) Energy-dense diet triggers changes in gut microbiota, reorganization of gut-brain vagal communication and increases body fat accumulation. Acta Neurobiol Exp 77:18–30. https://doi.org/10.21307/ane-2017-033CrossRef

Lambert JE, Parnell JA, Tunnicliffe JM, Han J, Sturzenegger T, Reimer RA (2017) Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial. Clin Nutr 36:126–133. https://doi.org/10.1016/j.clnu.2015.12.016CrossRefPubMed

Shimizu C, Kihara M, Aoe S, Araki S, Ito K, Hayashi K et al (2008) Effect of high β-glucan barley on serum cholesterol concentrations and visceral fat area in Japanese men—a randomized, double-blinded, placebo-controlled trial. Plant Foods Hum Nutr 63:21–25. https://doi.org/10.1007/s11130-007-0064-6CrossRefPubMed

Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su R et al (2014) Novel insights of dietary polyphenols and obesity. J Nutri Biochem 25:1–18. https://doi.org/10.1016/j.jnutbio.2013.09.001CrossRef

Franco BM, Latre ML, Esteban EMA, Ordov ás JM, Casasnovas JA, Peñalvo JL (2014) Soluble and insoluble dietary fiber intake and risk factors for metabolic syndrome and cardiovascular disease in middle-aged adults: the AWHS cohort. Nutr Hosp 30:1279–1288. https://doi.org/10.3305/nh.2014.30.6.7778CrossRef

Du H, Van Der ADL, Boshuizen HC, Forouhi NG, Wareham NJ, Halkjær J et al (2010) Dietary fiber and subsequent changes in body weight and waist circumference in European men and women. Am J Clin Nutr 91:329–336. https://doi.org/10.3945/ajcn.2009.28191CrossRefPubMed

Veldhuis L, Koppes LLJ, Driessen MT, Samoocha D, Twisk JWR (2010) Effects of dietary fibre intake during adolescence on the components of the metabolic syndrome at the age of 36 years: the Amsterdam Growth and Health Longitudinal Study. J Hum Nutr Diet 23:601–608. https://doi.org/10.1111/j.1365-277X.2010.01089.xCrossRefPubMed

10.

Ozato N, Saito S, Yamaguchi T, Katashima M, Tokuda I, Sawada K et al (2019) Association between nutrients and visceral fat in healthy Japanese adults: a 2-year longitudinal study brief title: micronutrients associated with visceral fat accumulation. Nutrients 7:11:2698. https://doi.org/10.3390/nu11112698CrossRef

11.

Ben Slama F, Jebali N, Chemli R, Ben Rayana C, Achour A, Najar MF et al (2011) Dietary fiber in the diets of urban Tunisian women: Association of fiber intake with BMI, waist circumference and blood chemistry: preliminary study. Clin Res Hepatol Gastroenterol 35:750–754. https://doi.org/10.1016/j.clinre.2011.04.005CrossRefPubMed

12.

Sekgala MD, McHiza ZJ, Parker WA, Monyeki KD (2018) Dietary fiber intake and metabolic syndrome risk factors among young South African adults. Nutrients 10:504. https://doi.org/10.3390/nu10040504CrossRefPubMedPubMedCentral

13.

Lairon D, Arnault N, Bertrais S, Planells R, Clero E, Hercberg S et al (2005) Dietary fiber intake and risk factors for cardiovascular disease in French adults. Am J Clin Nutr 82:1185–1194. https://doi.org/10.1093/ajcn/82.6.1185CrossRefPubMed

14.

Ludwig DS, Pereira MA, Kroenke CH, Hilner JE, Linda RD, Horn V et al (1999) Dietary Fiber, Weight Gain, and Cardiovascular Disease Risk Factors in Young Adults. JAMA 282:1539–1546. https://doi.org/10.1001/jama.282.16.1539

15.

Zhou Q, Wu J, Tang J, Wang JJ, Lu CH, Wang PX (2015) Beneficial effect of higher dietary fiber intake on plasma HDL-C and TC/HDL-C ratio among Chinese rural-to-urban migrant workers. Int J Environ Res Public Health 12:4726–4738. https://doi.org/10.3390/ijerph120504726CrossRefPubMedPubMedCentral

16.

Palmer BF, Clegg DJ (2015) The sexual dimorphism of obesity. Mol Cell Endocrinol 402:113–119. https://doi.org/10.1016/j.mce.2014.11.029CrossRefPubMed

17.

Karastergiou K, Smith SR, Greenberg AS, Fried SK (2012) Sex differences in human adipose tissues - the biology of pear shape. Biol Sex Differ 3:13. https://doi.org/10.1186/2042-6410-3-13CrossRefPubMedPubMedCentral

18.

Takachi R, Ishihara J, Iwasaki M, Hosoi S, Ishii Y, Sasazuki S et al (2011) Validity of a self-administered food frequency questionnaire for middle-aged urban cancer screenees: comparison with 4-day weighed dietary records. J Epidemiol 21:447–458. https://doi.org/10.2188/jea.je20100173CrossRefPubMedPubMedCentral

19.

The National Health and Nutrition Survey in Japan Ministry of Health, Labour and Welfare Publishing Web.https://www.mhlw.go.jp/content/000711006.pdf Accessed 17 November 2023

20.

Yamaji T, Iwasaki M, Sasazuki S, Sakamoto H, Yoshida T, Tsugane S (2012) Association between plasma 25-hydroxyvitamin D and colorectal adenoma according to dietary calcium intake and vitamin D receptor polymorphism. Am J Epidemiol 175:236–244. https://doi.org/10.1093/aje/kwr295CrossRefPubMed

21.

Yamaji T, Iwasaki M, Sasazuki S, Sakamoto H, Yoshida T, Tsugane S (2009) Methionine synthase A2756G polymorphism interacts with alcohol and folate intake to influence the risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev 18:267–274. https://doi.org/10.1158/1055-9965.EPI-08-0702CrossRefPubMed

22.

Yamaji T, Iwasaki M, Sasazuki S, Tsugane S (2010) Interaction between adiponectin and leptin influences the risk of colorectal adenoma. Cancer Res 70:5430–5437. https://doi.org/10.1158/0008-5472.CAN-10-0178CrossRefPubMed

23.

Standard Tables of Food Composition in Japan The Seventh Revised Version 2015. Ministry of Education Culture, Sports, Science and Technology-Japan (MEXT) Publishing Web http://www.mext.go.jp/en/policy/science_technology/policy/title01/detail01/1374030.htm Accessed 17 November 2023

24.

Willett WC, Howe GR, Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65:1220S–1228S. https://doi.org/10.1093/ajcn/65.4.1220SCrossRefPubMed

25.

Kikuchi H, Inoue S, Odagiri Y, Ihira H, Inoue M, Sawada N et al (2020) Intensity-specific validity and reliability of the Japan Public Health Center-based prospective study-physical activity questionnaire. Prev Med Rep 20:101–169. https://doi.org/10.1016/j.pmedr.2020.101169CrossRef

26.

Yamaji T, Iwasaki M, Sasazuki S, Kurahashi N, Mutoh M, Yamamoto S et al (2009) Visceral fat volume and the prevalence of colorectal adenoma. Am J Epidemiol 170:1502–1511. https://doi.org/10.1093/aje/kwp311CrossRefPubMed

27.

Watanabe T, Kobayashi S, Yamaguchi T, Hibi M, Fukuhara I, Osaki N (2019) Coffee abundant in chlorogenic acids reduces abdominal fat in overweight adults: a randomized, double-blind, controlled trial. Nutrients 11:1617. https://doi.org/10.3390/nu11071617CrossRefPubMedPubMedCentral

28.

Maki KC, Reeves MS, Farmer M, Yasunaga K, Matsuo N, Katsuragi Y et al (2009) Green tea catechin consumption enhances exercise-induced abdominal fat loss in overweight and obese adults. J Nutri 139:264–270. https://doi.org/10.3945/jn.108.098293CrossRef

29.

Yamaji T, Iwasaki M, Sasazuki S, Tsugane S (2012) Gender difference in the association of insulin and the insulin-like growth factor axis with colorectal neoplasia. Int J Obes 36:440–447. https://doi.org/10.1038/ijo.2011.114CrossRef

30.

World Health Organization Waist circumference and waist-hip ratio: report of a WHO expert consultation, Geneva, 8–11 December 2008

31.

Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T et al (2013) The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun 4:1829. https://doi.org/10.1038/ncomms2852CrossRefPubMed

32.

Chakraborti CK (2015) New-found link between microbiota and obesity. World J Gastrointest Pathophysiol 6:110–119. https://doi.org/10.4291/wjgp.v6.i4.110CrossRefPubMedPubMedCentral

33.

Chambers ES, Viardot A, Psichas A, Morrison DJ, Murphy KG, Zac-Varghese et al (2015) Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut 64:1744–1754. https://doi.org/10.1136/gutjnl-2014-307913CrossRefPubMed

34.

Kondo T, Kishi M, Fushimi T, Ugajin S, Kaga T (2009) Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. Biosci Biotechnol Biochem 73:1837–1843. https://doi.org/10.1271/bbb.90231CrossRefPubMed

35.

Ozato N, Saito S, Yamaguchi T, Katashima M, Tokuda I, Sawada K et al (2019) Blautia genus associated with visceral fat accumulation in adults 20–76 years of age. NPJ Biofilms Microbiomes 5:28. https://doi.org/10.1038/s41522-019-0101-xCrossRefPubMedPubMedCentral

36.

Takagi T, Naito Y, Inoue R, Kashiwagi S, Uchiyama K, Mizushima K et al (2019) Differences in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects. J Gastroenterol 54:53–63. https://doi.org/10.1007/s00535-018-1488-5CrossRefPubMed

37.

Koliada A, Moseiko V, Romanenko M, Lushchak O, Kryzhanovska N, Guryanov V et al (2021) Sex differences in the phylum-level human gut microbiota composition. BMC Microbiol 21:131. https://doi.org/10.1186/s12866-021-02198-yCrossRefPubMedPubMedCentral

38.

Tsukiyama H, Nagai Y, Matsubara F, Shimizu H, Iwamoto T, Yamanouchi E et al (2016) Proposed cut-off values of the waist circumference for metabolic syndrome based on visceral fat volume in a Japanese population. J Diabetes Investig 7:587–593. https://doi.org/10.1111/jdi.12454CrossRefPubMedPubMedCentral

Title: Sex difference in the association of dietary fiber intake with visceral fat volume in Japanese adults
Authors: Maki Igarashi
Motoki Iwasaki
Ryoko Katagiri
Shoichiro Tsugane
Nozomu Kobayashi
Taiki Yamaji
Publication date: 20-04-2024
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-024-03405-y

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits

Illustration of figure on mountain summit/© Orapun / Stock.adobe.com, STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com