Melatonin supplementation and pro-inflammatory mediators: a systematic review and meta-analysis of clinical trials
- 01-08-2020
- Review
Published in:
- Authors
- Meysam Zarezadeh
- Masoud Khorshidi
- Mohammadreza Emami
- Parisa Janmohammadi
- Hamed Kord-varkaneh
- Seyed Mohammad Mousavi
- Shimels Hussien Mohammed
- Ahmad Saedisomeolia
- Shahab Alizadeh
- Published in
- European Journal of Nutrition | Issue 5/2020
Abstract
Background
Inflammatory processes are involved in chronic diseases. It has been suggested that melatonin reduces inflammation by its radical scavenging properties; however, the results of the previous studies are inconclusive. The objective of the present meta-analysis is to determine the direction and magnitude of melatonin supplementation effect on inflammatory biomarkers.
Methods
Databases including PubMed, Scopus, Cochran Library, Embase, and Google Scholar were searched up to April 2019. Meta-analysis was performed using random-effect model. Subgroup analysis, sensitivity analysis, and meta-regression were also carried out.
Results
Thirteen eligible studies with 22 datasets with total sample size of 749 participants were included in the meta-analysis. Melatonin supplementation significantly decreased TNF-α and IL-6 levels [(WMD = − 2.24 pg/ml; 95% CI − 3.45, − 1.03; P < 0.001; I2 = 96.7%, Pheterogeneity < 0.001) and (WMD = − 30.25 pg/ml; 95% CI − 41.45, − 19.06; P < 0.001, I2 = 99.0%; Pheterogeneity < 0.001)], respectively. The effect of melatonin on CRP levels was marginal (WMD = − 0.45 mg/L; 95% CI − 0.94, 0.03; P = 0.06; I2 = 96.6%, Pheterogeneity < 0.001).
Conclusion
The results of the present meta-analysis support that melatonin supplementation could be effective on ameliorating of inflammatory mediators.
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