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European Journal of Nutrition
Published in: European Journal of Nutrition 1/2019

01-02-2019 | Original Contribution

Coffee consumption and risk of hypertension: a dose–response meta-analysis of prospective studies

Authors: Lanfranco D’Elia, Ersilia La Fata, Ferruccio Galletti, Luca Scalfi, Pasquale Strazzullo

Published in: European Journal of Nutrition | Issue 1/2019

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Abstract

Purpose

Recently, a large prospective study provided additional information concerning the debated possible association between habitual coffee consumption and risk of hypertension (HPT). Therefore, we updated the state of knowledge on this issue by carrying out a comprehensive new systematic review of the literature and a meta-analysis of the available relevant studies.

Methods

We performed a systematic search for prospective studies on general population, published without language restrictions (1966–August 2017). A random-effects dose–response meta-analysis was conducted to combine study specific relative risks (RRs) and 95% confidence intervals. Potential non-linear relation was investigated using restricted cubic splines.

Results

Four studies (196,256 participants, 41,184 diagnosis of HPT) met the inclusion criteria. Coffee intake was assessed by dietary questionnaire. Dose–response meta-analysis showed a non-linear relationship between coffee consumption and risk of HPT (p for non-linearity < 0.001). Whereas the habitual drinking of one or two cups of coffee per day, compared with non-drinking, was not associated with risk of HPT, a significantly protective effect of coffee consumption was found starting from the consumption of three cups of coffee per day (RR = 0.97, 95% CI = 0.94 to 0.99), and was confirmed for greater consumption.

Conclusions

The results of this analysis indicate that habitual moderate coffee intake is not associated with higher risk of HPT in the general population and that in fact a non-linear inverse dose–response relationship occurs between coffee consumption and risk of HPT.
Appendix
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Metadata
Title
Coffee consumption and risk of hypertension: a dose–response meta-analysis of prospective studies
Authors
Lanfranco D’Elia
Ersilia La Fata
Ferruccio Galletti
Luca Scalfi
Pasquale Strazzullo
Publication date
01-02-2019
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 1/2019
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-017-1591-z

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