Skip to main content
Top
Published in: European Journal of Nutrition 2/2013

Open Access 01-03-2013 | Original Contribution

Dairy intake in relation to cardiovascular disease mortality and all-cause mortality: the Hoorn Study

Authors: Marieke A. van Aerde, Sabita S. Soedamah-Muthu, Johanna M. Geleijnse, Marieke B. Snijder, Giel Nijpels, Coen D. A. Stehouwer, Jacqueline M. Dekker

Published in: European Journal of Nutrition | Issue 2/2013

Login to get access

Abstract

Purpose

Existing data from prospective cohort studies on dairy consumption and cardiovascular diseases are inconsistent. Even though the association between total dairy and cardiovascular diseases has been studied before, little is known about the effect of different types of dairy products on cardiovascular diseases (CVD). The objective of this study was to examine the relationship between (type of) dairy intake and CVD mortality and all-cause mortality in a Dutch population.

Methods

We examined the relationship between dairy intake and CVD mortality and all-cause mortality in 1956 participants of the Hoorn Study (aged 50–75 years), free of CVD at baseline. Hazard ratios with 95 % CIs were obtained for CVD mortality and all-cause mortality per standard deviation (SD) of the mean increase in dairy intake, with adjustment for age, sex, BMI, smoking, education, total energy intake, alcohol consumption, physical activity, and dietary intakes.

Results

During 12.4 years of follow-up, 403 participants died, of whom 116 had a fatal CVD event. Overall dairy intake was not associated with CVD mortality or all-cause mortality. Each SD increase in high-fat dairy intake was associated with a 32 % higher risk of CVD mortality (95 % CI; 7–61 %).

Conclusion

In this prospective cohort study, the intake of high-fat dairy products was associated with an increased risk of CVD mortality.
Literature
2.
go back to reference Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N (1997) A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 336(16):1117–1124CrossRef Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N (1997) A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 336(16):1117–1124CrossRef
3.
go back to reference St-Onge MP, Farnworth ER, Jones PJ (2000) Consumption of fermented and nonfermented dairy products: effects on cholesterol concentrations and metabolism. Am J Clin Nutr 71(3):674–681 St-Onge MP, Farnworth ER, Jones PJ (2000) Consumption of fermented and nonfermented dairy products: effects on cholesterol concentrations and metabolism. Am J Clin Nutr 71(3):674–681
4.
go back to reference Elwood PC, Pickering JE, Fehily AM, Hughes J, Ness AR (2004) Milk drinking, ischaemic heart disease and ischaemic stroke I. Evidence from the Caerphilly cohort. Eur J Clin Nutr 58(5):711–717CrossRef Elwood PC, Pickering JE, Fehily AM, Hughes J, Ness AR (2004) Milk drinking, ischaemic heart disease and ischaemic stroke I. Evidence from the Caerphilly cohort. Eur J Clin Nutr 58(5):711–717CrossRef
5.
go back to reference Shaper AG, Wannamethee G, Walker M (1991) Milk, butter, and heart disease. BMJ 302(6779):785–786CrossRef Shaper AG, Wannamethee G, Walker M (1991) Milk, butter, and heart disease. BMJ 302(6779):785–786CrossRef
6.
go back to reference Van der Vijver LP, van der Waal MA, Weterings KG, Dekker JM, Schouten EG, Kok FJ (1992) Calcium intake and 28-year cardiovascular and coronary heart disease mortality in Dutch civil servants. Int J Epidemiol 21(1):36–39CrossRef Van der Vijver LP, van der Waal MA, Weterings KG, Dekker JM, Schouten EG, Kok FJ (1992) Calcium intake and 28-year cardiovascular and coronary heart disease mortality in Dutch civil servants. Int J Epidemiol 21(1):36–39CrossRef
7.
go back to reference Al-Delaimy WK, Rimm E, Willett WC, Stampfer MJ, Hu FB (2003) A prospective study of calcium intake from diet and supplements and risk of ischemic heart disease among men. Am J Clin Nutr 77(4):814–818 Al-Delaimy WK, Rimm E, Willett WC, Stampfer MJ, Hu FB (2003) A prospective study of calcium intake from diet and supplements and risk of ischemic heart disease among men. Am J Clin Nutr 77(4):814–818
8.
go back to reference Houston DK, Driver KE, Bush AJ, Kritchevsky SB (2008) The association between cheese consumption and cardiovascular risk factors among adults. J Hum Nutr Diet 21(2):129–140CrossRef Houston DK, Driver KE, Bush AJ, Kritchevsky SB (2008) The association between cheese consumption and cardiovascular risk factors among adults. J Hum Nutr Diet 21(2):129–140CrossRef
9.
go back to reference Larsson SC, Mannisto S, Virtanen MJ, Kontto J, Albanes D, Virtamo J (2009) Dairy foods and risk of stroke. Epidemiology 20(3):355–360CrossRef Larsson SC, Mannisto S, Virtanen MJ, Kontto J, Albanes D, Virtamo J (2009) Dairy foods and risk of stroke. Epidemiology 20(3):355–360CrossRef
10.
go back to reference Umesawa M, Iso H, Date C, Yamamoto A, Toyoshima H, Watanabe Y, Kikuchi S, Koizumi A, Kondo T, Inaba Y, Tanabe N, Tamakoshi A (2006) Dietary intake of calcium in relation to mortality from cardiovascular disease: the JACC Study. Stroke 37(1):20–26CrossRef Umesawa M, Iso H, Date C, Yamamoto A, Toyoshima H, Watanabe Y, Kikuchi S, Koizumi A, Kondo T, Inaba Y, Tanabe N, Tamakoshi A (2006) Dietary intake of calcium in relation to mortality from cardiovascular disease: the JACC Study. Stroke 37(1):20–26CrossRef
11.
go back to reference Bostick RM, Kushi LH, Wu Y, Meyer KA, Sellers TA, Folsom AR (1999) Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 149(2):151–161CrossRef Bostick RM, Kushi LH, Wu Y, Meyer KA, Sellers TA, Folsom AR (1999) Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 149(2):151–161CrossRef
12.
go back to reference Ness AR, Smith GD, Hart C (2001) Milk, coronary heart disease and mortality. J Epidemiol Community Health 55(6):379–382CrossRef Ness AR, Smith GD, Hart C (2001) Milk, coronary heart disease and mortality. J Epidemiol Community Health 55(6):379–382CrossRef
13.
go back to reference Wang L, Manson JE, Buring JE, Lee IM, Sesso HD (2008) Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women. Hypertension 51(4):1073–1079CrossRef Wang L, Manson JE, Buring JE, Lee IM, Sesso HD (2008) Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women. Hypertension 51(4):1073–1079CrossRef
14.
go back to reference Alonso A, Beunza JJ, Delgado-Rodriguez M, Martinez JA, Martinez-Gonzalez MA (2005) Low-fat dairy consumption and reduced risk of hypertension: the Seguimiento Universidad de Navarra (SUN) cohort. Am J Clin Nutr 82(5):972–979 Alonso A, Beunza JJ, Delgado-Rodriguez M, Martinez JA, Martinez-Gonzalez MA (2005) Low-fat dairy consumption and reduced risk of hypertension: the Seguimiento Universidad de Navarra (SUN) cohort. Am J Clin Nutr 82(5):972–979
15.
go back to reference Engberink MF, Hendriksen MA, Schouten EG, van Rooij FJ, Hofman A, Witteman JC, Geleijnse JM (2009) Inverse association between dairy intake and hypertension: the Rotterdam Study. Am J Clin Nutr 89(6):1877–1883CrossRef Engberink MF, Hendriksen MA, Schouten EG, van Rooij FJ, Hofman A, Witteman JC, Geleijnse JM (2009) Inverse association between dairy intake and hypertension: the Rotterdam Study. Am J Clin Nutr 89(6):1877–1883CrossRef
16.
go back to reference Tholstrup T (2006) Dairy products and cardiovascular disease. Curr Opin Lipidol 17(1):1–10 Tholstrup T (2006) Dairy products and cardiovascular disease. Curr Opin Lipidol 17(1):1–10
17.
go back to reference German JB, Gibson RA, Krauss RM, Nestel P, Lamarche B, van Staveren WA, Steijns JM, de Groot LC, Lock AL, Destaillats F (2009) A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk. Eur J Nutr 48(4):191–203CrossRef German JB, Gibson RA, Krauss RM, Nestel P, Lamarche B, van Staveren WA, Steijns JM, de Groot LC, Lock AL, Destaillats F (2009) A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk. Eur J Nutr 48(4):191–203CrossRef
18.
go back to reference Gibson RA, Makrides M, Smithers LG, Voevodin M, Sinclair AJ (2009) The effect of dairy foods on CHD: a systematic review of prospective cohort studies. Br J Nutr 102(9):1267–1275CrossRef Gibson RA, Makrides M, Smithers LG, Voevodin M, Sinclair AJ (2009) The effect of dairy foods on CHD: a systematic review of prospective cohort studies. Br J Nutr 102(9):1267–1275CrossRef
19.
go back to reference Elwood PC, Pickering JE, Hughes J, Fehily AM, Ness AR (2004) Milk drinking, ischaemic heart disease and ischaemic stroke II. Evidence from cohort studies. Eur J Clin Nutr 58(5):718–724CrossRef Elwood PC, Pickering JE, Hughes J, Fehily AM, Ness AR (2004) Milk drinking, ischaemic heart disease and ischaemic stroke II. Evidence from cohort studies. Eur J Clin Nutr 58(5):718–724CrossRef
20.
go back to reference Elwood PC, Givens DI, Beswick AD, Fehily AM, Pickering JE, Gallacher J (2008) The survival advantage of milk and dairy consumption: an overview of evidence from cohort studies of vascular diseases, diabetes and cancer. J Am Coll Nutr 27(6):723S–734S Elwood PC, Givens DI, Beswick AD, Fehily AM, Pickering JE, Gallacher J (2008) The survival advantage of milk and dairy consumption: an overview of evidence from cohort studies of vascular diseases, diabetes and cancer. J Am Coll Nutr 27(6):723S–734S
21.
go back to reference Soedamah-Muthu SS, Ding EL, Al-Delaimy WK, Hu FB, Engberink MF, Willett WC, Geleijnse JM (2011) Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Am J Clin Nutr 93(1):158–171CrossRef Soedamah-Muthu SS, Ding EL, Al-Delaimy WK, Hu FB, Engberink MF, Willett WC, Geleijnse JM (2011) Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Am J Clin Nutr 93(1):158–171CrossRef
22.
go back to reference Mooy JM, Grootenhuis PA, de Vries H, Valkenburg HA, Bouter LM, Kostense PJ, Heine RJ (1995) Prevalence and determinants of glucose intolerance in a Dutch Caucasian population: the Hoorn Study. Diabetes Care 18(9):1270–1273CrossRef Mooy JM, Grootenhuis PA, de Vries H, Valkenburg HA, Bouter LM, Kostense PJ, Heine RJ (1995) Prevalence and determinants of glucose intolerance in a Dutch Caucasian population: the Hoorn Study. Diabetes Care 18(9):1270–1273CrossRef
23.
go back to reference Grootenhuis PA, Westenbrink S, Sie CMTL, De Neeling JND, Kok FJ, Bouter LM (1995) A semiquantitative food frequency questionnaire for use in epidemiologic research among the elderly: validation by comparison with dietary history. J Clin Epidemiol 48(7):859–868CrossRef Grootenhuis PA, Westenbrink S, Sie CMTL, De Neeling JND, Kok FJ, Bouter LM (1995) A semiquantitative food frequency questionnaire for use in epidemiologic research among the elderly: validation by comparison with dietary history. J Clin Epidemiol 48(7):859–868CrossRef
24.
go back to reference Snijder MB, van der Heijden AA, van Dam RM, Stehouwer CD, Hiddink GJ, Nijpels G, Heine RJ, Bouter LM, Dekker JM (2007) Is higher dairy consumption associated with lower body weight and fewer metabolic disturbances? The Hoorn Study. Am J Clin Nutr 85(4):989–995 Snijder MB, van der Heijden AA, van Dam RM, Stehouwer CD, Hiddink GJ, Nijpels G, Heine RJ, Bouter LM, Dekker JM (2007) Is higher dairy consumption associated with lower body weight and fewer metabolic disturbances? The Hoorn Study. Am J Clin Nutr 85(4):989–995
25.
go back to reference Willett WC, Howe GR, Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65(4 Suppl):1220S–1228S; discussion 1229S-1231S Willett WC, Howe GR, Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65(4 Suppl):1220S–1228S; discussion 1229S-1231S
26.
go back to reference Engberink MF, Geleijnse JM, de Jong N, Smit HA, Kok FJ, Verschuren WM (2009) Dairy intake, blood pressure, and incident hypertension in a general Dutch population. J Nutr 139(3):582–587CrossRef Engberink MF, Geleijnse JM, de Jong N, Smit HA, Kok FJ, Verschuren WM (2009) Dairy intake, blood pressure, and incident hypertension in a general Dutch population. J Nutr 139(3):582–587CrossRef
27.
go back to reference Snijder MB, van Dam RM, Stehouwer CD, Hiddink GJ, Heine RJ, Dekker JM (2008) A prospective study of dairy consumption in relation to changes in metabolic risk factors: the Hoorn Study. Obesity (Silver Spring) 16(3):706–709CrossRef Snijder MB, van Dam RM, Stehouwer CD, Hiddink GJ, Heine RJ, Dekker JM (2008) A prospective study of dairy consumption in relation to changes in metabolic risk factors: the Hoorn Study. Obesity (Silver Spring) 16(3):706–709CrossRef
28.
go back to reference Hu FB, Stampfer MJ, Manson JE, Ascherio A, Colditz GA, Speizer FE, Hennekens CH, Willett WC (1999) Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am J Clin Nutr 70(6):1001–1008 Hu FB, Stampfer MJ, Manson JE, Ascherio A, Colditz GA, Speizer FE, Hennekens CH, Willett WC (1999) Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am J Clin Nutr 70(6):1001–1008
29.
go back to reference Goldbohm RA, Chorus AM, Galindo Garre F, Schouten LJ, van den Brandt PA (2011) Dairy consumption and 10-year total and cardiovascular mortality: a prospective cohort study in the Netherlands. Am J Clin Nutr 93(3):615–627CrossRef Goldbohm RA, Chorus AM, Galindo Garre F, Schouten LJ, van den Brandt PA (2011) Dairy consumption and 10-year total and cardiovascular mortality: a prospective cohort study in the Netherlands. Am J Clin Nutr 93(3):615–627CrossRef
30.
go back to reference Moss M, Freed D (2003) The cow and the coronary: epidemiology, biochemistry and immunology. Int J Cardiol 87(2–3):203–216CrossRef Moss M, Freed D (2003) The cow and the coronary: epidemiology, biochemistry and immunology. Int J Cardiol 87(2–3):203–216CrossRef
31.
go back to reference Segall JJ (1977) Is milk a coronary health hazard? Br J Prev Soc Med 31(2):81–85 Segall JJ (1977) Is milk a coronary health hazard? Br J Prev Soc Med 31(2):81–85
32.
go back to reference Rossouw JE, Burger EM, Van der Vyver P, Ferreira JJ (1981) The effect of skim milk, yoghurt, and full cream milk on human serum lipids. Am J Clin Nutr 34(3):351–356 Rossouw JE, Burger EM, Van der Vyver P, Ferreira JJ (1981) The effect of skim milk, yoghurt, and full cream milk on human serum lipids. Am J Clin Nutr 34(3):351–356
33.
go back to reference Steinmetz KA, Childs MT, Stimson C, Kushi LH, McGovern PG, Potter JD, Yamanaka WK (1994) Effect of consumption of whole milk and skim milk on blood lipid profiles in healthy men. Am J Clin Nutr 59(3):612–618 Steinmetz KA, Childs MT, Stimson C, Kushi LH, McGovern PG, Potter JD, Yamanaka WK (1994) Effect of consumption of whole milk and skim milk on blood lipid profiles in healthy men. Am J Clin Nutr 59(3):612–618
34.
go back to reference Moss M (2002) Does milk cause coronary heart disease? J Nutr Environ Med 12(3):207–216CrossRef Moss M (2002) Does milk cause coronary heart disease? J Nutr Environ Med 12(3):207–216CrossRef
35.
go back to reference Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC (2004) Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr 134(11):3100–3105 Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC (2004) Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr 134(11):3100–3105
36.
go back to reference Beulens JW, Bots ML, Atsma F, Bartelink ML, Prokop M, Geleijnse JM, Witteman JC, Grobbee DE, van der Schouw YT (2009) High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis 203(2):489–493CrossRef Beulens JW, Bots ML, Atsma F, Bartelink ML, Prokop M, Geleijnse JM, Witteman JC, Grobbee DE, van der Schouw YT (2009) High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis 203(2):489–493CrossRef
37.
go back to reference Bernstein AM, Sun Q, Hu FB, Stampfer MJ, Manson JE, Willett WC (2010) Major dietary protein sources and risk of coronary heart disease in women. Circulation 122(9):876–883CrossRef Bernstein AM, Sun Q, Hu FB, Stampfer MJ, Manson JE, Willett WC (2010) Major dietary protein sources and risk of coronary heart disease in women. Circulation 122(9):876–883CrossRef
38.
go back to reference European Nutrition and Health Report (2009) Forum of nutrition. In: Elmadfa I (ed) Vienna, vol 62. Karger, Switzerland European Nutrition and Health Report (2009) Forum of nutrition. In: Elmadfa I (ed) Vienna, vol 62. Karger, Switzerland
Metadata
Title
Dairy intake in relation to cardiovascular disease mortality and all-cause mortality: the Hoorn Study
Authors
Marieke A. van Aerde
Sabita S. Soedamah-Muthu
Johanna M. Geleijnse
Marieke B. Snijder
Giel Nijpels
Coen D. A. Stehouwer
Jacqueline M. Dekker
Publication date
01-03-2013
Publisher
Springer-Verlag
Published in
European Journal of Nutrition / Issue 2/2013
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-012-0363-z

Other articles of this Issue 2/2013

European Journal of Nutrition 2/2013 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.