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Published in: European Journal of Nutrition 2/2008

01-05-2008

Anticarcinogenic compounds of olive oil and related biomarkers

Authors: Theodore G. Sotiroudis, Soterios A. Kyrtopoulos

Published in: European Journal of Nutrition | Special Issue 2/2008

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Abstract

Olive oil, one of the oldest vegetable oils consumed without any refining, is associated with a reduced risk of a number of common cancers. Minor constituents of virgin olive oil have been suggested to be among the major chemopreventive components. A brief overview is presented of recent findings concerning the bioavailability of certain important olive oil minor components including efficient antioxidant polyphenols, the triterpene hydrocarbon squalene and β-sitosterol, considered as putative nutritional biomarkers, in relation to the incidence of cancer.
Literature
1.
go back to reference Bouic PJD (2001) The role of phytosterols and phytosterolins in immune modulation: a review of the past 10 years. Curr Opin Clin Nutr Metab Care 4:471–475CrossRef Bouic PJD (2001) The role of phytosterols and phytosterolins in immune modulation: a review of the past 10 years. Curr Opin Clin Nutr Metab Care 4:471–475CrossRef
2.
go back to reference Caruso D, Visioli F, Patelli R, Galli C, Galli G (2001) Urinary excretion of olive oil phenols and their metabolites in humans. Metab Clin Exp 50:1426–1428 Caruso D, Visioli F, Patelli R, Galli C, Galli G (2001) Urinary excretion of olive oil phenols and their metabolites in humans. Metab Clin Exp 50:1426–1428
3.
go back to reference Casas EM, Albadalego MF, Planells MIC, Colomer MF, Raventos RML, Fornell RD (2001) Tyrosol bioavailability in humans after ingestion of virgin olive oil. Clin Chem 47:341–343 Casas EM, Albadalego MF, Planells MIC, Colomer MF, Raventos RML, Fornell RD (2001) Tyrosol bioavailability in humans after ingestion of virgin olive oil. Clin Chem 47:341–343
4.
go back to reference Criado MN, Morello JR, Motilva MJ, Romero MP (2004) Effect of growing area on pigment and phenolic fractions of virgin olive oils of the Arbequina variety in Spain. J Am Oil Chem Soc 81:633–640CrossRef Criado MN, Morello JR, Motilva MJ, Romero MP (2004) Effect of growing area on pigment and phenolic fractions of virgin olive oils of the Arbequina variety in Spain. J Am Oil Chem Soc 81:633–640CrossRef
5.
go back to reference Fielding JM, Rowley KG, Kooper P, O’Dea K (2005) Increases in plasma lycopene concentration after consumption of tomatoes cooked with olive oil. Asia Pac J Clin Nutr 14:131–136 Fielding JM, Rowley KG, Kooper P, O’Dea K (2005) Increases in plasma lycopene concentration after consumption of tomatoes cooked with olive oil. Asia Pac J Clin Nutr 14:131–136
6.
go back to reference Grizis C, Atta-Politou J, Koupparis MA (2003) Simultaneous determination of oleuropein and tyrosol in plasma using high performance liquid chromatography with UV detection. J Liq Chromatogr Relat Technol 26:599–616CrossRef Grizis C, Atta-Politou J, Koupparis MA (2003) Simultaneous determination of oleuropein and tyrosol in plasma using high performance liquid chromatography with UV detection. J Liq Chromatogr Relat Technol 26:599–616CrossRef
7.
go back to reference Jansen GHE, Arts ICW, Nielen MWF, Muller M, Hollman PCH, Keijer J (2005) Uptake and metabolism of enterolactone and enterodiol by human colon epithelial cells. Arch Biochem Biophys 435:74–82CrossRef Jansen GHE, Arts ICW, Nielen MWF, Muller M, Hollman PCH, Keijer J (2005) Uptake and metabolism of enterolactone and enterodiol by human colon epithelial cells. Arch Biochem Biophys 435:74–82CrossRef
8.
go back to reference Ketomaki A, Gylling H, Siimes MA, Vuorio A, Miettinen TA (2003) Squalene and noncholesterol sterols in serum and lipoproteins of children with and without familial hypercholesterolemia. Ped Res 53:648–653CrossRef Ketomaki A, Gylling H, Siimes MA, Vuorio A, Miettinen TA (2003) Squalene and noncholesterol sterols in serum and lipoproteins of children with and without familial hypercholesterolemia. Ped Res 53:648–653CrossRef
9.
go back to reference Kuijsten A, Arts JCW, Vree TB, Hollman PCH (2005) Pharmacokinetics of enterolignans in healthy men and women consuming a single dose of secoisolariciresinol diglucoside. J Nutr 135:795–801 Kuijsten A, Arts JCW, Vree TB, Hollman PCH (2005) Pharmacokinetics of enterolignans in healthy men and women consuming a single dose of secoisolariciresinol diglucoside. J Nutr 135:795–801
10.
go back to reference Lee A, Thurnham DI, Chopra M (2000) Consumption of tomato products with olive oil, but not sunflower oil increases the antioxidant activity of plasama. Free Rad Biol Med 29:1051–1055CrossRef Lee A, Thurnham DI, Chopra M (2000) Consumption of tomato products with olive oil, but not sunflower oil increases the antioxidant activity of plasama. Free Rad Biol Med 29:1051–1055CrossRef
11.
go back to reference Li JH, Awad AB, Fink CS, Wu YWB, Trevisan M, Muti P (2001) Measurement variability of plasma beta-sitosterol and campesterol, two new biomarkers for cancer prevention. Eur J Cancer Prev 10:245–249CrossRef Li JH, Awad AB, Fink CS, Wu YWB, Trevisan M, Muti P (2001) Measurement variability of plasma beta-sitosterol and campesterol, two new biomarkers for cancer prevention. Eur J Cancer Prev 10:245–249CrossRef
12.
go back to reference Maruvada P, Srivastava S (2004) Biomarkers for cancer diagnosis: Implications for nutritional research. J Nutr 134:1640S–1645S Maruvada P, Srivastava S (2004) Biomarkers for cancer diagnosis: Implications for nutritional research. J Nutr 134:1640S–1645S
13.
go back to reference McCann SE, Muti P, Vito D, Edge SB, Trevisan M, Freudenheim JL (2004) Dietary lignan intakes and risk of pre- and postmenopausal breast cancer. Int J Cancer 111:440–443CrossRef McCann SE, Muti P, Vito D, Edge SB, Trevisan M, Freudenheim JL (2004) Dietary lignan intakes and risk of pre- and postmenopausal breast cancer. Int J Cancer 111:440–443CrossRef
14.
go back to reference Miro-Casas E, Covas MI, Fito M, Fare-Albadalejo M, Marrugat J, de la Torre R (2003) Tyrosol and hydroxytyrosol are absorbed from moderate and sustained doses of virgin olive oil in humans. Eur J Clin Nutr 57:186–190CrossRef Miro-Casas E, Covas MI, Fito M, Fare-Albadalejo M, Marrugat J, de la Torre R (2003) Tyrosol and hydroxytyrosol are absorbed from moderate and sustained doses of virgin olive oil in humans. Eur J Clin Nutr 57:186–190CrossRef
15.
go back to reference Miro-Casas E, Farre Albaladejo M, Covas MI, Rodriguez JO, Menoyo Colomer E, Lamuela Raventos RM, de la Torre R (2001) Capillary gas chromatography-mass spectrometry quantitative determination of hydroxytyrosol and tyrosol in human urine after olive oil intake. Anal Biochem 294:63–72CrossRef Miro-Casas E, Farre Albaladejo M, Covas MI, Rodriguez JO, Menoyo Colomer E, Lamuela Raventos RM, de la Torre R (2001) Capillary gas chromatography-mass spectrometry quantitative determination of hydroxytyrosol and tyrosol in human urine after olive oil intake. Anal Biochem 294:63–72CrossRef
16.
go back to reference Nenadis N, Tsimidou M (2002) Determination of squalene in olive oil using fractional crystallization for sample preparation. J Am Oil Chem Soc 79:257–259CrossRef Nenadis N, Tsimidou M (2002) Determination of squalene in olive oil using fractional crystallization for sample preparation. J Am Oil Chem Soc 79:257–259CrossRef
17.
go back to reference Newmark HL (1997) Squalene, olive oil, and cancer risk: a review and hypothesis. Cancer Epidemiol Biomarkers Prev 6:1101–1103 Newmark HL (1997) Squalene, olive oil, and cancer risk: a review and hypothesis. Cancer Epidemiol Biomarkers Prev 6:1101–1103
18.
go back to reference Owen RW, Haubner R, Wurtele G, Hull WE, Spiegelhalder B, Bartsch H (2004) Olives and olive oil in cancer prevention. Eur J Cancer Prev 13:319–326CrossRef Owen RW, Haubner R, Wurtele G, Hull WE, Spiegelhalder B, Bartsch H (2004) Olives and olive oil in cancer prevention. Eur J Cancer Prev 13:319–326CrossRef
19.
go back to reference Peeters PHM, Keinan-Boker L, van der Schouw YT, Grobbee DE (2003) Phytoestrogens and breast cancer risk-Review of the epidemiological evidence. Breast Cancer Res Treatment 77:171–183CrossRef Peeters PHM, Keinan-Boker L, van der Schouw YT, Grobbee DE (2003) Phytoestrogens and breast cancer risk-Review of the epidemiological evidence. Breast Cancer Res Treatment 77:171–183CrossRef
20.
go back to reference Relas H, Gylling H, Rajaratnam RA, Miettinen TA (2000) Postprandial retinyl palmitate and squalene metabolism is age dependent. J Gerontol SerA 55:B515–B521 Relas H, Gylling H, Rajaratnam RA, Miettinen TA (2000) Postprandial retinyl palmitate and squalene metabolism is age dependent. J Gerontol SerA 55:B515–B521
21.
go back to reference Saudek CD, Frier BM, Liu GCK (1978) Plasma squalene: lipoprotein distribution and kinetic analysis. J Lipid Res 19:827–835 Saudek CD, Frier BM, Liu GCK (1978) Plasma squalene: lipoprotein distribution and kinetic analysis. J Lipid Res 19:827–835
22.
go back to reference Smith TJ (2000) Squalene: potential chemopreventive agent. Expert Opinion Investig Drugs 9:1841–1848CrossRef Smith TJ (2000) Squalene: potential chemopreventive agent. Expert Opinion Investig Drugs 9:1841–1848CrossRef
23.
go back to reference Sotiroudis TG, Kyrtopoulos SA, Xenakis A, Sotiroudis GT (2003) Chemopreventive potential of minor components of olive oil against cancer. Ital J Food Sci 15:169–185 Sotiroudis TG, Kyrtopoulos SA, Xenakis A, Sotiroudis GT (2003) Chemopreventive potential of minor components of olive oil against cancer. Ital J Food Sci 15:169–185
24.
go back to reference Tsarbopoulos A, Gikas E, Papadopoulos N, Aligiannis N, Kafatos A (2003) Simultaneous determination of oleuropein and its metabolites in plasma by high-performance liquid chromatography. J Chromatogr B 785:157–164CrossRef Tsarbopoulos A, Gikas E, Papadopoulos N, Aligiannis N, Kafatos A (2003) Simultaneous determination of oleuropein and its metabolites in plasma by high-performance liquid chromatography. J Chromatogr B 785:157–164CrossRef
25.
go back to reference Visioli F, Caruso D, Galli C, Viappiani S, Galli G, Sala A (2000) Olive oil rich in in natural catecholic phenols decrease isoprostane excretion in humans. Biochem Biophys Res Commun 278:797–799CrossRef Visioli F, Caruso D, Galli C, Viappiani S, Galli G, Sala A (2000) Olive oil rich in in natural catecholic phenols decrease isoprostane excretion in humans. Biochem Biophys Res Commun 278:797–799CrossRef
26.
go back to reference Visioli F, Galli C, Bornet F, Mattei A, Patelli R, Galli G, Caruso D (2000) Olive oil phenolics are dose-dependently absorbed in humans. FEBS Lett 468:159–160CrossRef Visioli F, Galli C, Bornet F, Mattei A, Patelli R, Galli G, Caruso D (2000) Olive oil phenolics are dose-dependently absorbed in humans. FEBS Lett 468:159–160CrossRef
27.
go back to reference Visioli F, Galli C, Galli G, Caruso D (2002) Biological activities and metabolic fate of olive oil phenols. Eur J Lip Sci Technol 104:677–684CrossRef Visioli F, Galli C, Galli G, Caruso D (2002) Biological activities and metabolic fate of olive oil phenols. Eur J Lip Sci Technol 104:677–684CrossRef
28.
go back to reference Webb AL, McCullough ML (2005) Dietary lignans: potential role in cancer prevention. Nutr Cancer 51:117–131CrossRef Webb AL, McCullough ML (2005) Dietary lignans: potential role in cancer prevention. Nutr Cancer 51:117–131CrossRef
29.
go back to reference Weinbrenner T, Fito M, Farre AM, Saez GT, Rijken P, Tormos C, Coolen S, De la Torre R, Covas MI (2004) Bioavailability of phenolic compounds from olive oil and oxidative/antioxidant status at postprandial state in healthy humans. Drugs Exp Clin Res 30:207–212 Weinbrenner T, Fito M, Farre AM, Saez GT, Rijken P, Tormos C, Coolen S, De la Torre R, Covas MI (2004) Bioavailability of phenolic compounds from olive oil and oxidative/antioxidant status at postprandial state in healthy humans. Drugs Exp Clin Res 30:207–212
Metadata
Title
Anticarcinogenic compounds of olive oil and related biomarkers
Authors
Theodore G. Sotiroudis
Soterios A. Kyrtopoulos
Publication date
01-05-2008
Publisher
D. Steinkopff-Verlag
Published in
European Journal of Nutrition / Issue Special Issue 2/2008
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-008-2008-9

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