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01-03-2011 | Original Paper

Long-term outcome after drug-eluting stent implantation in comparison with bare metal stents: a single centre experience

Authors: Ioannis Tentzeris, Rudolf Jarai, Serdar Farhan, Johann Wojta, Martin Schillinger, Alexander Geppert, Michael Nürnberg, Gerhard Unger, Kurt Huber

Published in: Clinical Research in Cardiology | Issue 3/2011

Abstract

Background

The aim of our study was to evaluate the effect of drug-eluting stents (DES) compared with bare-metal stents (BMS) on all-cause mortality and target vessel revascularization (TVR) in a “real-world” clinical setting.

Methods and results

One thousand four hundred and ninety consecutive patients, who underwent PCI, were included in a prospective registry from January 2003 until December 2006. Patients were divided retrospectively into two groups: those who received a DES and those who received a BMS. The primary combined endpoint all-cause mortality or TVR and the individual endpoints death and TVR were evaluated during a mean follow-up period of 24.56 ± 12.5 months (range 6–52 months).

In total 1,033 patients (69.3%) received BMS, while 457 patients (30.7%) received DES. With respect to clinical characteristics, significant differences between groups were found for age, hyperlipidemia, diabetes mellitus, heart failure, previous cerebral insult and presence of acute coronary syndrome (ACS) during intervention. Propensity score analysis was performed in attempt to eliminate this selection bias.

With respect to the combined endpoint all-cause death or TVR, 12.9% of patients with DES and 21.3% with BMS (p = 0.015) had an event during the follow-up. 12.3% of patients with BMS but only 5.7% with DES died during the follow-up (p = 0.025). Thirty-three patients (7.2%) of the DES group and 99 patients (9.6%) of the BMS group (p = 0.1) needed TVR.

Conclusion

Our results obtained in a “real-world” clinical setting exhibit a clinical long-term benefit for DES compared with BMS and underline the safety and efficacy of DES over BMS.

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Title: Long-term outcome after drug-eluting stent implantation in comparison with bare metal stents: a single centre experience
Authors: Ioannis Tentzeris
Rudolf Jarai
Serdar Farhan
Johann Wojta
Martin Schillinger
Alexander Geppert
Michael Nürnberg
Gerhard Unger
Kurt Huber
Publication date: 01-03-2011
Publisher: Springer-Verlag
Published in: Clinical Research in Cardiology / Issue 3/2011
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-010-0228-5

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Long-term outcome after drug-eluting stent implantation in comparison with bare metal stents: a single centre experience

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