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International Journal of Colorectal Disease

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01-06-2020 | Rectal Cancer | Review

Total mesorectal excision plus lateral lymph node dissection vs TME on rectal cancer patients: a meta-analysis

Authors: Xingmeng Wang, Aifeng Qiu, Xiaobing Liu, Yuhua Shi

Published in: International Journal of Colorectal Disease | Issue 6/2020

Abstract

Objective

Our study is the first meta-analysis to compare total mesorectal excision (TME) plus lateral lymph node dissection (LLND) with TME on rectal cancer patients regarding outcomes including overall survival, disease-free survival, local recurrence, complications, urinary dysfunction, and sexual dysfunction.

Methods

PubMed, Embase, and Cochrane library were searched for publications up to October 2019. Two investigators independently screened the studies for eligibility and extracted specific data. Relevant data were analyzed by Review Manager version 5.3.

Results

Patients in TME + LLND group suffered more complications (OR = 1.48, 95% CI [1.07, 2.03], P = 0.02) compared with TME group; no significant difference was observed in overall survival (HR = 1.11, 95% CI [0.77, 1.61], P = 0.57), disease-free survival (HR = 1.05, 95% CI [0.85, 1.30], P = 0.64), local recurrence (OR = 0.93, 95% CI [0.56, 1.54], P = 0.78), and urinary dysfunction (OR = 1.60, 95% CI [0.66, 3.87], P = 0.3).

Conclusion

TME + LLND may cause more complications compared with TME on rectal cancer patients. However, the definite conclusion still requires more researches.

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Title: Total mesorectal excision plus lateral lymph node dissection vs TME on rectal cancer patients: a meta-analysis
Authors: Xingmeng Wang
Aifeng Qiu
Xiaobing Liu
Yuhua Shi
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keywords: Rectal Cancer
Rectal Cancer
Published in: International Journal of Colorectal Disease / Issue 6/2020
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-020-03610-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Total mesorectal excision plus lateral lymph node dissection vs TME on rectal cancer patients: a meta-analysis

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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