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International Journal of Colorectal Disease

Published in:

01-03-2015 | Review

Management of nodal disease from colon cancer in the laparoscopic era

Authors: Corrado Pedrazzani, Lelde Lauka, Simone Sforza, Andrea Ruzzenente, Filippo Nifosì, GianGaetano Delaini, Alfredo Guglielmi

Published in: International Journal of Colorectal Disease | Issue 3/2015

Abstract

Purpose

In colon cancer (CC), nodal involvement is the main prognostic factor following potentially curative (R0) resection. The purpose of this study was to examine data from the literature to provide an up-to-date analysis of the management of nodal disease with special reference to laparoscopic treatment.

Methods

MEDLINE and EMBASE databases were searched for potentially eligible studies published in English up to July 15, 2014.

Results

In CC, nodal involvement is a frequent event and represents the main risk of cancer recurrence. Node negative patients recur in 10–30 % of cases most likely due to underdiagnosed or undertreated nodal disease. Extended colonic resections (complete mesocolic excision with central vascular ligation; D3 lymphadenectomy) provides a survival benefit and better local control. Sentinel lymph node mapping in addition to standard surgical resection represents an option for improving staging of clinical node negative patients. Both extended resection and sentinel lymph node mapping are feasible in a laparoscopic setting.

Conclusions

Both extended colonic resection and sentinel lymph node mapping should play a role in the laparoscopic treatment of CC with the purpose of improving control and staging of nodal disease.

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Title: Management of nodal disease from colon cancer in the laparoscopic era
Authors: Corrado Pedrazzani
Lelde Lauka
Simone Sforza
Andrea Ruzzenente
Filippo Nifosì
GianGaetano Delaini
Alfredo Guglielmi
Publication date: 01-03-2015
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 3/2015
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-014-2075-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Management of nodal disease from colon cancer in the laparoscopic era

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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