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Open Access 01-02-2017 | Original Article

Bowel perforation after liver transplantation for biliary atresia: a retrospective study of care in the transition from children to adulthood

Authors: Yusuke Yanagi, Toshiharu Matsuura, Makoto Hayashida, Yoshiaki Takahashi, Koichiro Yoshimaru, Genshirou Esumi, Tomoaki Taguchi

Published in: Pediatric Surgery International | Issue 2/2017

Abstract

Purpose

We evaluated the outcomes of liver transplantation (LT) in pediatric and adult patients with biliary atresia (BA). We focused on bowel perforation after LT (BPLT) as the most common surgical complication and analyzed its risk factors.

Methods

This was a retrospective analysis of 70 BA patients who underwent LT. The patients were divided into three groups according to the timing of LT: within the first year of age (Group A), between 1 and 12 years of age (Group B), and after 12 years of age (Group C). The outcomes of LT and the clinical presentations of BPLT were compared. The surgical variables of patients with and without BPLT were analyzed to assess the risk factors.

Results

The timing of LT did not affect patient survival. The incidence of BPLT was significantly higher in Group C. In Group C, BPLT progressed to severe peritonitis. No cases of BPLT-associated mortality were observed. A multivariate analysis revealed that a prolonged operative time for LT was an independent risk factor (p = 0.03).

Conclusion

The clinical course after transplantation was complicated after adolescence. BPLT should be strongly suspected and relaparotomy should be performed in a timely manner for patients undergoing LT after adolescence.

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Title: Bowel perforation after liver transplantation for biliary atresia: a retrospective study of care in the transition from children to adulthood
Authors: Yusuke Yanagi
Toshiharu Matsuura
Makoto Hayashida
Yoshiaki Takahashi
Koichiro Yoshimaru
Genshirou Esumi
Tomoaki Taguchi
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 2/2017
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-016-4008-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Bowel perforation after liver transplantation for biliary atresia: a retrospective study of care in the transition from children to adulthood

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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