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01-08-2011 | Original Article

Pediatric living donor liver transplantation for biliary atresia with hepatopulmonary syndrome: the gift of a second wind

Authors: Taizen Urahashi, Koichi Mizuta, Yukihiro Sanada, Minoru Umehara, Taiichi Wakiya, Shuji Hishikawa, Masanobu Hyodo, Yasunaru Sakuma, Takehito Fujiwara, Yoshikazu Yasuda, Hideo Kawarasaki

Published in: Pediatric Surgery International | Issue 8/2011

Abstract

Purpose

Hepatopulmonary syndrome (HPS) is a progressive, deteriorating complication of end-stage liver disease (ESLD) that occurs in 13–47% of liver transplant candidates. Although LT is the only therapeutic option for HPS, it has a high morbidity and mortality, especially in patients with severe hypoxemia before transplantation, but the course of HPS after living donor liver transplantation (LDLT), especially for biliary atresia (BA) patients is not well established.

Patients and methods

The present study evaluated 122 patients who received an LDLT for BA and of these, 3 patients had HPS at the time of LDLT in a single-center series.

Results

Two patients of the HPS patients them had biliary and/or vascular complications, but they recovered uneventfully with interventional treatment. None of the patients required supplemental oxygen and had no residual cardiopulmonary abnormalities at a follow-up of more than 24 months.

Conclusion

Although a series of three patients is too small for definitive conclusion and further investigations must be conducted, pediatric LDLT can be a favorable therapeutic option for HPS.

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Title: Pediatric living donor liver transplantation for biliary atresia with hepatopulmonary syndrome: the gift of a second wind
Authors: Taizen Urahashi
Koichi Mizuta
Yukihiro Sanada
Minoru Umehara
Taiichi Wakiya
Shuji Hishikawa
Masanobu Hyodo
Yasunaru Sakuma
Takehito Fujiwara
Yoshikazu Yasuda
Hideo Kawarasaki
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: Pediatric Surgery International / Issue 8/2011
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-011-2866-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Pediatric living donor liver transplantation for biliary atresia with hepatopulmonary syndrome: the gift of a second wind

Abstract

Purpose

Patients and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Patients and methods

Results

Conclusion

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