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01-02-2012 | Original Article

Matriderm^® 1 mm versus Integra^® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats

Authors: Sophie Böttcher-Haberzeth, Thomas Biedermann, Clemens Schiestl, Fabienne Hartmann-Fritsch, Jörg Schneider, Ernst Reichmann, Martin Meuli

Published in: Pediatric Surgery International | Issue 2/2012

Abstract

Purpose

Dermal templates, such as Matriderm^® and Integra^®, are widely used in plastic and reconstructive surgery, often as two-step procedures. A recent development is the application of thin dermal templates covered with split thickness skin grafts in one-step procedures. In this experimental study, we compare the two thin matrices Matriderm^® 1 mm and Integra^® Single Layer in a one-step procedure with particular focus on neodermis formation.

Methods

Matriderm^® 1 mm and Integra^® Dermal Regeneration Template—Single Layer (1.3 mm) were compared in a rat model. In three groups of five animals each, a full thickness wound was covered with (a) Matriderm^® 1 mm and neonatal rat epidermis, (b) Integra^® Single Layer and neonatal rat epidermis, or, (c) neonatal rat epidermis only (control). Histological sections 2 weeks post transplantation were analyzed with regard to take of template and epidermis, neodermal thickness, collagen deposition, vascularization, and inflammatory response.

Results

Take of both templates was complete in all animals. The Matriderm^®-based neodermis was thinner but showed a higher cell density than the Integra^®-based neodermis. The other parameters were similar in both matrices.

Conclusion

The two templates demonstrate a comparable biological behavior early after transplantation. The only difference was found regarding neodermal thickness, probably resulting from faster degradation of Matriderm^®. These preliminary data suggest that both dermal templates appear similarly suitable for transplantation in a one-step procedure.

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Title: Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats
Authors: Sophie Böttcher-Haberzeth
Thomas Biedermann
Clemens Schiestl
Fabienne Hartmann-Fritsch
Jörg Schneider
Ernst Reichmann
Martin Meuli
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: Pediatric Surgery International / Issue 2/2012
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-011-2990-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Matriderm^® 1 mm versus Integra^® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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