Skip to main content
Top
Published in: Heart and Vessels 2/2024

04-10-2023 | Obesity | Original Article

Visceral adiposity in patients with lipomatous hypertrophy of the interatrial septum

Authors: Carlo A. Mallio, Gianfranco Di Gennaro, Federico Greco, Andrea Pescosolido, Caterina Bernetti, Claudia Lucia Piccolo, Vitaliano Buffa, Carlo C. Quattrocchi, Bruno Beomonte Zobel

Published in: Heart and Vessels | Issue 2/2024

Login to get access

Abstract

Lipomatous hypertrophy of the interatrial septum (LHIS) is a benign cardiac mass determined by abnormal deposition of adipose tissue in the interatrial septum. The quantitative relationship between LHIS and visceral adiposity has not been explored to date.In this retrospective study, three groups of consecutive patients undergoing CT imaging were enrolled: L + with LHIS, L− without LHIS, and LO− without both LHIS and history of malignancies. Areas of total adipose tissue (TAT), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and LHIS areas were calculated on CT images. The relationship between LHIS and abdominal fat distribution was investigated with linear regression models. Bonferroni correction was applied to account for multiple testing. Statistical significance was set at 5%. In this study we enrolled a total of 175 subjects: 58 (33.14%) with LHIS (L +), 51(29.14%) without LHIS (L−) and 66 (37.71%) without both LHIS and medical history of malignancies (LO-). VAT (coeff: 105.82; 95% CI 59.37–152.27), SAT (coeff: 74.59; 95% CI 31.63–117.54), and TAT (coeff: 190.37; 95% CI 115.02–265.72), were significantly higher in L + patients. Moreover, VAT (coeff: 24.95; 95% CI 6.94–42.96) and TAT (coeff: 36.58; 95% CI 8.75–64.41) were statistically significant linear predictors for LHIS area. Here, we report a novel association between LHIS and visceral adiposity using a quantitative CT-based imaging approach. The results are of great importance also because they might drive early identification of subjects with LHIS at risk for visceral obesity, and trigger lifestyle interventions aimed at weight loss.
Literature
1.
go back to reference Silbiger JJ, Bazaz R, Trost B (2010) Lipomatous hypertrophy of the interatrial septum revisited. J Am Soc Echocardiogr 23:789–790CrossRefPubMed Silbiger JJ, Bazaz R, Trost B (2010) Lipomatous hypertrophy of the interatrial septum revisited. J Am Soc Echocardiogr 23:789–790CrossRefPubMed
2.
go back to reference Shirani J, Roberts WC (1993) Clinical, electrocardiographic and morphologic features of massive fatty deposits (“lipomatous hypertrophy”) in the atrial septum. J Am Coll Cardiol 22:226–238CrossRefPubMed Shirani J, Roberts WC (1993) Clinical, electrocardiographic and morphologic features of massive fatty deposits (“lipomatous hypertrophy”) in the atrial septum. J Am Coll Cardiol 22:226–238CrossRefPubMed
3.
go back to reference Heyer CM, Kagel T, Lemburg SP, Bauer TT, Nicolas V (2003) Lipomatous hypertrophy of the interatrial septum. Chest 124:2068–2073CrossRefPubMed Heyer CM, Kagel T, Lemburg SP, Bauer TT, Nicolas V (2003) Lipomatous hypertrophy of the interatrial septum. Chest 124:2068–2073CrossRefPubMed
5.
go back to reference Pochis WT, Saeian K, Sagar KB (1992) Usefulness of transesophageal echocardiography in diagnosing lipomatous hypertrophy of the atrial septum with comparison to transthoracic echocardiography. Am J Cardiol 70:396–398CrossRefPubMed Pochis WT, Saeian K, Sagar KB (1992) Usefulness of transesophageal echocardiography in diagnosing lipomatous hypertrophy of the atrial septum with comparison to transthoracic echocardiography. Am J Cardiol 70:396–398CrossRefPubMed
6.
go back to reference Xanthos T, Giannakopoulos N, Papadimitriou L (2007) Lipomatous hypertrophy of the interatrial septum: a pathological and clinical approach. Int J Cardiol 121:4–8CrossRefPubMed Xanthos T, Giannakopoulos N, Papadimitriou L (2007) Lipomatous hypertrophy of the interatrial septum: a pathological and clinical approach. Int J Cardiol 121:4–8CrossRefPubMed
7.
go back to reference Meaney JF, Kazerooni EA, Jamadar DA, Korobkin M (1997) CT appearance of lipomatous hypertrophy of the interatrial septum. Am J Roentgenol 168:1081–1084CrossRef Meaney JF, Kazerooni EA, Jamadar DA, Korobkin M (1997) CT appearance of lipomatous hypertrophy of the interatrial septum. Am J Roentgenol 168:1081–1084CrossRef
8.
go back to reference Rosenquist GC, Sweeney LJ, Ruckman RN, McAllister HA (1979) Atrial septal thickness and area in normal heart specimens and in those with ostium secundum atrial septal defects. J Clin Ultrasound 7:345–348CrossRefPubMed Rosenquist GC, Sweeney LJ, Ruckman RN, McAllister HA (1979) Atrial septal thickness and area in normal heart specimens and in those with ostium secundum atrial septal defects. J Clin Ultrasound 7:345–348CrossRefPubMed
9.
go back to reference Dotti MT, Mondillo S, Plewnia K, Agricola E, Federico A (1998) Cerebrotendinous xanthomatosis: evidence of lipomatous hypertrophy of the atrial septum. J Neurol 245:723–726CrossRefPubMed Dotti MT, Mondillo S, Plewnia K, Agricola E, Federico A (1998) Cerebrotendinous xanthomatosis: evidence of lipomatous hypertrophy of the atrial septum. J Neurol 245:723–726CrossRefPubMed
10.
go back to reference Enzi G, Busetto L, Ceschin E, Coin A, Digito M, Pigozzo S (2002) Multiple symmetric lipomatosis: clinical aspects and outcome in a long-term longitudinal study. Int J Obes Relat Metab Disord 26:253–261CrossRefPubMed Enzi G, Busetto L, Ceschin E, Coin A, Digito M, Pigozzo S (2002) Multiple symmetric lipomatosis: clinical aspects and outcome in a long-term longitudinal study. Int J Obes Relat Metab Disord 26:253–261CrossRefPubMed
11.
go back to reference Greco F, Mallio CA (2021) Relationship between visceral adipose tissue and genetic mutations (VHL and KDM5C) in clear cell renal cell carcinoma. Radiol Med 126:645–651CrossRefPubMed Greco F, Mallio CA (2021) Relationship between visceral adipose tissue and genetic mutations (VHL and KDM5C) in clear cell renal cell carcinoma. Radiol Med 126:645–651CrossRefPubMed
12.
go back to reference Quattrocchi CC, Giona A, Di Martino A, Gaudino F, Mallio CA, Errante Y, Occhicone F, Vitali MA, Zobel BB, Denaro V (2015) Lumbar subcutaneous edema and degenerative spinal disease in patients with low back pain: a retrospective MRI study. Musculoskelet Surg 99:159–163CrossRefPubMed Quattrocchi CC, Giona A, Di Martino A, Gaudino F, Mallio CA, Errante Y, Occhicone F, Vitali MA, Zobel BB, Denaro V (2015) Lumbar subcutaneous edema and degenerative spinal disease in patients with low back pain: a retrospective MRI study. Musculoskelet Surg 99:159–163CrossRefPubMed
13.
go back to reference Greco F, Cirimele V, Mallio C, Zobel B, Grasso R (2018) Increased visceral adipose tissue in male patients with clear cell renal cell carcinoma. Clin Cancer Investig J 7:132CrossRef Greco F, Cirimele V, Mallio C, Zobel B, Grasso R (2018) Increased visceral adipose tissue in male patients with clear cell renal cell carcinoma. Clin Cancer Investig J 7:132CrossRef
14.
go back to reference Zhang HP, Zou J, Xu ZQ, Ruan J, Yang SD, Yin Y, Mu HJ (2017) Association of leptin, visfatin, apelin, resistin and adiponectin with clear cell renal cell carcinoma. Oncol Lett 13:463–468CrossRefPubMed Zhang HP, Zou J, Xu ZQ, Ruan J, Yang SD, Yin Y, Mu HJ (2017) Association of leptin, visfatin, apelin, resistin and adiponectin with clear cell renal cell carcinoma. Oncol Lett 13:463–468CrossRefPubMed
15.
16.
go back to reference Yaghootkar H, Lotta LA, Tyrrell J, Smit RA, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, Ruth KS, Padmanabhan S, Jukema JW, Palmer CC, Hattersley A, Freathy RM, Langenberg C, Wareham NJ, Wood AR, Murray A, Weedon MN, Sattar N, Pearson E, Scott RA, Frayling TM (2016) Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension, and heart disease. Diabetes 65:2448–2460CrossRefPubMed Yaghootkar H, Lotta LA, Tyrrell J, Smit RA, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, Ruth KS, Padmanabhan S, Jukema JW, Palmer CC, Hattersley A, Freathy RM, Langenberg C, Wareham NJ, Wood AR, Murray A, Weedon MN, Sattar N, Pearson E, Scott RA, Frayling TM (2016) Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension, and heart disease. Diabetes 65:2448–2460CrossRefPubMed
17.
go back to reference Smith U, Kahn BB (2016) Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. J Intern Med 280:465–475CrossRefPubMedPubMedCentral Smith U, Kahn BB (2016) Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. J Intern Med 280:465–475CrossRefPubMedPubMedCentral
19.
go back to reference Mallio CA, Greco F, Pacella G, Schena E, Beomonte Zobel B (2018) Gender-based differences of abdominal adipose tissue distribution in non-small cell lung cancer patients. Shanghai Chest 2:20–20CrossRef Mallio CA, Greco F, Pacella G, Schena E, Beomonte Zobel B (2018) Gender-based differences of abdominal adipose tissue distribution in non-small cell lung cancer patients. Shanghai Chest 2:20–20CrossRef
22.
24.
go back to reference Neeland IJ, Ross R, Després JP, Matsuzawa Y, Yamashita S, Shai I, Seidell J, Magni P, Santos RD, Arsenault B, Cuevas A, Hu FB, Griffin B, Zambon A, Barter P, Fruchart JC, Eckel RH (2019) Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. Lancet Diabetes Endocrinol 7:715–725. https://doi.org/10.1016/S2213-8587(19)30084-1CrossRefPubMed Neeland IJ, Ross R, Després JP, Matsuzawa Y, Yamashita S, Shai I, Seidell J, Magni P, Santos RD, Arsenault B, Cuevas A, Hu FB, Griffin B, Zambon A, Barter P, Fruchart JC, Eckel RH (2019) Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. Lancet Diabetes Endocrinol 7:715–725. https://​doi.​org/​10.​1016/​S2213-8587(19)30084-1CrossRefPubMed
25.
go back to reference Greco F, Salgado R, Van Hecke W, Del Buono R, Parizel PM, Mallio CA (2022) Epicardial and pericardial fat analysis on CT images and artificial intelligence: a literature review. Quant Imaging Med Surg 12:2075–2089CrossRefPubMedPubMedCentral Greco F, Salgado R, Van Hecke W, Del Buono R, Parizel PM, Mallio CA (2022) Epicardial and pericardial fat analysis on CT images and artificial intelligence: a literature review. Quant Imaging Med Surg 12:2075–2089CrossRefPubMedPubMedCentral
27.
go back to reference Neeland IJ, Ayers CR, Rohatgi AK, Turer AT, Berry JD, Das SR, Vega GL, Khera A, McGuire DK, Grundy SM, de Lemos JA (2013) Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults. Obesity 21:E439–E447. https://doi.org/10.1002/oby.20135CrossRefPubMed Neeland IJ, Ayers CR, Rohatgi AK, Turer AT, Berry JD, Das SR, Vega GL, Khera A, McGuire DK, Grundy SM, de Lemos JA (2013) Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults. Obesity 21:E439–E447. https://​doi.​org/​10.​1002/​oby.​20135CrossRefPubMed
Metadata
Title
Visceral adiposity in patients with lipomatous hypertrophy of the interatrial septum
Authors
Carlo A. Mallio
Gianfranco Di Gennaro
Federico Greco
Andrea Pescosolido
Caterina Bernetti
Claudia Lucia Piccolo
Vitaliano Buffa
Carlo C. Quattrocchi
Bruno Beomonte Zobel
Publication date
04-10-2023
Publisher
Springer Japan
Published in
Heart and Vessels / Issue 2/2024
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-023-02319-9

Other articles of this Issue 2/2024

Heart and Vessels 2/2024 Go to the issue