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01-01-2015 | Original Article

Evaluation of coronary artery disease and cardiac morphology and function in patients with hypertrophic cardiomyopathy, using cardiac computed tomography

Authors: Satoshi Okayama, Tsunenari Soeda, Rika Kawakami, Yasuhiro Takami, Satoshi Somekawa, Tomoya Ueda, Yu Sugawara, Takaki Matsumoto, Ji Hee Sung, Taku Nishida, Shiro Uemura, Yoshihiko Saito

Published in: Heart and Vessels | Issue 1/2015

Abstract

Coronary artery disease and cardiac morphology and function were evaluated in 51 patients with hypertrophic cardiomyopathy (HCM), without typical chest pain, using cardiac computed tomography (CT). This study investigated the prevalence of coronary artery disease, the indicators of obstructive coronary stenosis, and the magnitude of left ventricular (LV) hypertrophy. The patients’ mean coronary artery calcium score was 198.8 ± 312.0 and was positively correlated with the number of coronary risk factors (r = 0.32; P < 0.05). Of the 51 patients with HCM, 42 (82.4 %) had some degree of stenosis and 8 (15.7 %) had obstructive stenosis. Noncalcified and mixed plaques were detected in 14 (27.5 %) and 11 (21.6 %) patients, respectively. Multivariate logistic regression revealed that diabetes was an independent indicator of the presence of obstructive stenosis in HCM patients. Multivariate linear regression revealed that low estimated glomerular filtration rates and high triglyceride concentrations were independent indicators of higher LV mass indexes. In conclusion, cardiac CT revealed that coronary artery disease was common among patients with HCM. The presence of obstructive coronary stenosis and the magnitude of LV hypertrophy were related to the presence of diabetes, triglyceride levels, and estimated glomerular filtration rate.

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Title: Evaluation of coronary artery disease and cardiac morphology and function in patients with hypertrophic cardiomyopathy, using cardiac computed tomography
Authors: Satoshi Okayama
Tsunenari Soeda
Rika Kawakami
Yasuhiro Takami
Satoshi Somekawa
Tomoya Ueda
Yu Sugawara
Takaki Matsumoto
Ji Hee Sung
Taku Nishida
Shiro Uemura
Yoshihiko Saito
Publication date: 01-01-2015
Publisher: Springer Japan
Published in: Heart and Vessels / Issue 1/2015
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI: https://doi.org/10.1007/s00380-013-0452-9

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Evaluation of coronary artery disease and cardiac morphology and function in patients with hypertrophic cardiomyopathy, using cardiac computed tomography

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