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World Journal of Urology

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Open Access 01-10-2011 | Topic paper

Novel contrast-enhanced ultrasound imaging in prostate cancer

Authors: Martijn Smeenge, Massimo Mischi, M. Pilar Laguna Pes, Jean J. M. C. H. de la Rosette, Hessel Wijkstra

Published in: World Journal of Urology | Issue 5/2011

Abstract

Purpose

The purposes of this paper were to present the current status of contrast-enhanced transrectal ultrasound imaging and to discuss the latest achievements and techniques now under preclinical testing.

Objective

Although grayscale transrectal ultrasound is the standard method for prostate imaging, it lacks accuracy in the detection and localization of prostate cancer. With the introduction of contrast-enhanced ultrasound (CEUS), perfusion imaging of the microvascularization became available. By this, cancer-induced neovascularisation can be visualized with the potential to improve ultrasound imaging for prostate cancer detection and localization significantly. For example, several studies have shown that CEUS-guided biopsies have the same or higher PCa detection rate compared with systematic biopsies with less biopsies needed.

Materials and methods

This paper describes the current status of CEUS and discusses novel quantification techniques that can improve the accuracy even further. Furthermore, quantification might decrease the user-dependency, opening the door to use in the routine clinical environment. A new generation of targeted microbubbles is now under pre-clinical testing and showed avidly binding to VEGFR-2, a receptor up-regulated in prostate cancer due to angiogenesis. The first publications regarding a targeted microbubble ready for human use will be discussed.

Conclusion

Ultrasound-assisted drug delivery gives rise to a whole new set of therapeutic options, also for prostate cancer. A major breakthrough in the future can be expected from the clinical use of targeted microbubbles for drug delivery for prostate cancer diagnosis as well as treatment.

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Title: Novel contrast-enhanced ultrasound imaging in prostate cancer
Authors: Martijn Smeenge
Massimo Mischi
M. Pilar Laguna Pes
Jean J. M. C. H. de la Rosette
Hessel Wijkstra
Publication date: 01-10-2011
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 5/2011
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-011-0747-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Novel contrast-enhanced ultrasound imaging in prostate cancer

Abstract

Purpose

Objective

Materials and methods

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Objective

Materials and methods

Conclusion

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