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20-12-2023 | Multiple Sclerosis | Commentary

Looking at the rim in multiple sclerosis: new MRI-based biomarkers may open our eyes to the disease’s evolution

Authors: Jean-Christophe Brisset, François Cotton

Published in: European Radiology | Issue 2/2024

Excerpt

The identification of new prognostic biomarkers for progressive multiple sclerosis (MS) is crucial for the development of new therapeutic interventions targeting this phase of the disease [1]. The study entitled “Deeply 3D-T1-TFE hypointense voxels are characteristic of phase-rim lesions in multiple sclerosis” in this current issue of European Radiology investigates the use of a derived metric from 3D T1-weighted turbo field echo (3DT1TFE) MRI to identify phase-rim lesions (PRLs), which have been proposed as possible markers of progressive MS [2]. …

Ontaneda D, Chitnis T, Rammohan K, Obeidat AZ (2023) Identification and management of subclinical disease activity in early multiple sclerosis: a review. J Neurol. https://doi.org/10.1007/s00415-023-12021-5CrossRefPubMed

Naval-Baudin P, Pons-Escoda A, Camins À et al (2023) Deeply 3D-T1-TFE hypointense voxels are characteristic of phase-rim lesions in multiple sclerosis. Eur Radiol https://doi.org/10.1007/s00330-023-09784-w

Meaton I, Altokhis A, Allen CM et al (2022) Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis. Mult Scler 28:2212–2220. https://doi.org/10.1177/13524585221118677CrossRefPubMedPubMedCentral

Maggi P, Sati P, Nair G et al (2020) Paramagnetic rim lesions are specific to multiple sclerosis: an international multicenter 3T MRI study. Ann Neurol 88:1034–1042. https://doi.org/10.1002/ana.25877CrossRefPubMedPubMedCentral

Martire MS, Moiola L, Rocca MA et al (2022) What is the potential of paramagnetic rim lesions as diagnostic indicators in multiple sclerosis? Expert Rev Neurother 22:829–837. https://doi.org/10.1080/14737175.2022.2143265CrossRefPubMed

Caruana G, Auger C, Pessini LM et al (2022) SWI as an alternative to contrast-enhanced imaging to detect acute MS lesions. AJNR Am J Neuroradiol 43:534–539. https://doi.org/10.3174/ajnr.A7474CrossRefPubMedPubMedCentral

Absinta M, Sati P, Masuzzo F et al (2019) Association of chronic active multiple sclerosis lesions with disability in vivo. JAMA Neurol 76:1474. https://doi.org/10.1001/jamaneurol.2019.2399CrossRefPubMedPubMedCentral

Hemond CC, Reich DS, Dundamadappa SK (2022) Paramagnetic rim lesions in multiple sclerosis: comparison of visualization at 1.5-T and 3-T MRI. AJR Am J Roentgenol 219:120–131. https://doi.org/10.2214/AJR.21.26777CrossRefPubMed

Brisset J-C, Vukusic S, Cotton F (2021) Update on brain MRI for the diagnosis and follow-up of MS patients. Presse Med 50:104067. https://doi.org/10.1016/j.lpm.2021.104067CrossRefPubMed

10.

Cacciaguerra L, Storelli L, Rocca MA, Filippi M (2022) Current and future applications of artificial intelligence in multiple sclerosis. In: Augmenting neurological disorder prediction and rehabilitation using artificial intelligence. Elsevier, pp 107–144

11.

Bonacchi R, Filippi M, Rocca MA (2022) Role of artificial intelligence in MS clinical practice. Neuroimage Clin 35:103065. https://doi.org/10.1016/j.nicl.2022.103065CrossRefPubMedPubMedCentral

12.

La Rosa F, Wynen M, Al-Louzi O et al (2022) Cortical lesions, central vein sign, and paramagnetic rim lesions in multiple sclerosis: Emerging machine learning techniques and future avenues. Neuroimage Clin 36:103205. https://doi.org/10.1016/j.nicl.2022.103205CrossRefPubMedPubMedCentral

13.

Calvi A, Clarke MA, Prados F et al (2023) Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis. Mult Scler 29:352–362. https://doi.org/10.1177/13524585221141964CrossRefPubMed

14.

Wattjes MP, Ciccarelli O, Reich DS et al (2021) 2021 MAGNIMS–CMSC–NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis. Lancet Neurol 20:653–670. https://doi.org/10.1016/S1474-4422(21)00095-8CrossRefPubMed

Title: Looking at the rim in multiple sclerosis: new MRI-based biomarkers may open our eyes to the disease’s evolution
Authors: Jean-Christophe Brisset
François Cotton
Publication date: 20-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: Multiple Sclerosis
Biomarkers
Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: European Radiology / Issue 2/2024
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-023-10482-w

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Looking at the rim in multiple sclerosis: new MRI-based biomarkers may open our eyes to the disease’s evolution

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