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18-07-2023 | Anthracycline | Commentary

Multiparametric cardiac magnetic resonance unveiling the mechanisms and early manifestations of anticancer drug cardiotoxicity

Authors: Marco Francone, Stefano Figliozzi, Lorenzo Monti, Christian Loewe, Federica Catapano

Published in: European Radiology | Issue 12/2023

Excerpt

Global 5-year survival rate for cancer patients has reached an unprecedented all-time high of 66% [1]. This remarkable progress is largely attributed to the development of innovative, biology-driven therapeutic approaches that leverage specific molecular and cellular features of cancer cells, such as genetic mutations, altered signaling pathways, and immune evasion mechanisms, to devise precise and targeted treatments, thereby enhancing efficacy while minimizing off-target effects. …

International Agency for Research on Cancer. In: Cancer today Available via https://gco.iarc.fr/today/home. Accessed 22 Jun 2023

Porter C, Azam TU, Mohananey D et al (2022) Permissive cardiotoxicity: the clinical crucible of cardio-oncology. JACC CardioOncol 4:302–312. https://doi.org/10.1016/j.jaccao.2022.07.005

Esposito A, Gallone G, Palmisano A et al (2020) The current landscape of imaging recommendations in cardiovascular clinical guidelines: toward an imaging-guided precision medicine. Radiol Med 125:1013–1023. https://doi.org/10.1007/s11547-020-01286-9

Čelutkienė J, Pudil R, López-Fernández T et al (2020) Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the Eur. Eur J Heart Fail 22:1504–1524. https://doi.org/10.1002/ejhf.1957CrossRefPubMed

Bellenger NG, Burgess MI, Ray SG et al (2000) Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance. Are they interchangeable? Eur Heart J 21:1387–1396. https://doi.org/10.1053/euhj.2000.2011CrossRefPubMed

Ong G, Brezden-Masley C, Dhir V et al (2018) Myocardial strain imaging by cardiac magnetic resonance for detection of subclinical myocardial dysfunction in breast cancer patients receiving trastuzumab and chemotherapy. Int J Cardiol 261:228–233. https://doi.org/10.1016/j.ijcard.2018.03.041CrossRefPubMed

Farhad H, Staziaki PV, Addison D et al (2016) Characterization of the changes in cardiac structure and function in mice treated with anthracyclines using serial cardiac magnetic resonance imaging. Circ Cardiovasc Imaging 9:1–8. https://doi.org/10.1161/CIRCIMAGING.115.003584CrossRef

Saunderson CED, Plein S, Manisty CH (2021) Role of cardiovascular magnetic resonance imaging in cardio-oncology. Eur Heart J Cardiovasc Imaging 22:383–396. https://doi.org/10.1093/ehjci/jeaa345CrossRefPubMed

Thavendiranathan P, Shalmon T, Fan CS et al (2023) Comprehensive cardiovascular magnetic resonance tissue characterization and cardiotoxicity in women with breast cancer. JAMA Cardiol 8:524–534. https://doi.org/10.1001/jamacardio.2023.0494

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Neilan TG, Coelho-Filho OR, Pena-Herrera D et al (2012) Left ventricular mass in patients with a cardiomyopathy after treatment with anthracyclines. Am J Cardiol 110:1679–1686. https://doi.org/10.1016/j.amjcard.2012.07.040CrossRefPubMedPubMedCentral

Title: Multiparametric cardiac magnetic resonance unveiling the mechanisms and early manifestations of anticancer drug cardiotoxicity
Authors: Marco Francone
Stefano Figliozzi
Lorenzo Monti
Christian Loewe
Federica Catapano
Publication date: 18-07-2023
Publisher: Springer Berlin Heidelberg
Keywords: Anthracycline
Trastuzumab
Published in: European Radiology / Issue 12/2023
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-023-09948-8

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Multiparametric cardiac magnetic resonance unveiling the mechanisms and early manifestations of anticancer drug cardiotoxicity

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