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European Radiology
Published in: European Radiology 1/2022

01-01-2022 | Magnetic Resonance Imaging | Hepatobiliary-Pancreas

Simultaneous evaluation of perfusion and morphology using GRASP MRI in hepatic fibrosis

Authors: Jeong Hee Yoon, Jeong Min Lee, Mi Hye Yu, Bo Yun Hur, Robert Grimm, Steven Sourbron, Hersh Chandarana, Yohan Son, Susmita Basak, Kyoung-Bun Lee, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh

Published in: European Radiology | Issue 1/2022

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Abstract

Objectives

To determine if golden-angle radial sparse parallel (GRASP) dynamic contrast-enhanced (DCE)-MRI allows simultaneous evaluation of perfusion and morphology in liver fibrosis.

Methods

Participants who were scheduled for liver biopsy or resection were enrolled (NCT02480972). Images were reconstructed at 12-s temporal resolution for morphologic assessment and at 3.3-s temporal resolution for quantitative evaluation. The image quality of the morphologic images was assessed on a four-point scale, and the Liver Imaging Reporting and Data System score was recorded for hepatic observations. Comparisons were made between quantitative parameters of DCE-MRI for the different fibrosis stages, and for hepatocellular carcinoma (HCCs) with different LR features.

Results

DCE-MRI of 64 participants (male = 48) were analyzed. The overall image quality consistently stood at 3.5 ± 0.4 to 3.7 ± 0.4 throughout the exam. Portal blood flow significantly decreased in participants with F2–F3 (n = 18, 175 ± 110 mL/100 mL/min) and F4 (n = 12, 98 ± 47 mL/100 mL/min) compared with those in participants with F0–F1 (n = 34, 283 ± 178 mL/100 mL/min, p < 0.05 for all). In participants with F4, the arterial fraction and extracellular volume were significantly higher than those in participants with F0–F1 and F2–F3 (p < 0.05). Compared with HCCs showing non-LR-M features (n = 16), HCCs with LR-M (n = 5) had a significantly prolonged mean transit time and lower arterial blood flow (p < 0.05).

Conclusions

Liver MRI using GRASP obtains both sufficient spatial resolution for confident diagnosis and high temporal resolution for pharmacokinetic modeling. Significant differences were found between the MRI-derived portal blood flow at different hepatic fibrosis stages.

Key Points

  • A single MRI examination is able to provide both images with sufficient spatial resolution for anatomic evaluation and those with high temporal resolution for pharmacokinetic modeling.
  • Portal blood flow was significantly lower in clinically significant hepatic fibrosis and mean transit time and extracellular volume increased in cirrhosis, compared with those in no or mild hepatic fibrosis.
  • HCCs with different LR features showed different quantitative parameters of DCE-MRI: longer mean transit time and lower arterial flow were observed in HCCs with LR-M features.
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Metadata
Title
Simultaneous evaluation of perfusion and morphology using GRASP MRI in hepatic fibrosis
Authors
Jeong Hee Yoon
Jeong Min Lee
Mi Hye Yu
Bo Yun Hur
Robert Grimm
Steven Sourbron
Hersh Chandarana
Yohan Son
Susmita Basak
Kyoung-Bun Lee
Nam-Joon Yi
Kwang-Woong Lee
Kyung-Suk Suh
Publication date
01-01-2022
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 1/2022
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-021-08087-2

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