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Open Access 01-01-2021 | Computed Tomography

Quantitative dual-energy CT material decomposition of holmium microspheres: local concentration determination evaluated in phantoms and a rabbit tumor model

Authors: Ralf Gutjahr, Robbert C. Bakker, Feiko Tiessens, Sebastiaan A. van Nimwegen, Bernhard Schmidt, Johannes Frank Wilhelmus Nijsen

Published in: European Radiology | Issue 1/2021

Abstract

Objectives

The purpose of this study was to assess the feasibility of dual-energy CT-based material decomposition using dual-X-ray spectra information to determine local concentrations of holmium microspheres in phantoms and in an animal model.

Materials and methods

A spectral calibration phantom with a solution containing 10 mg/mL holmium and various tube settings was scanned using a third-generation dual-energy CT scanner to depict an energy-dependent and material-dependent enhancement vectors. A serial dilution of holmium (microspheres) was quantified by spectral material decomposition and compared with known holmium concentrations. Subsequently, the feasibility of the spectral material decomposition was demonstrated in situ in three euthanized rabbits with injected (radioactive) holmium microspheres.

Results

The measured CT values of the holmium solutions scale linearly to all measured concentrations and tube settings (R² = 1.00). Material decomposition based on CT acquisitions using the tube voltage combinations of 80/150 Sn kV or 100/150 Sn kV allow the most accurate quantifications for concentrations down to 0.125 mg/mL holmium.

Conclusion

Dual-energy CT facilitates image-based material decomposition to detect and quantify holmium microspheres in phantoms and rabbits.

Key Points

• Quantification of holmium concentrations based on dual-energy CT is obtained with good accuracy.

• The optimal tube-voltage pairs for quantifying holmium were 80/150 Sn kV and 100/150 Sn kV using a third-generation dual-source CT system.

• Quantification of accumulated holmium facilitates the assessment of local dosimetry for radiation therapies.

Di Chiro G, Brooks RA, Kessler RM et al (1979) Tissue signatures with dual-energy computed tomography. Radiology 131:521–523CrossRef

Genant HK, Boyd D (1977) Quantitative bone mineral analysis using dual energy computed tomography. Invest Radiol 12:545–551CrossRef

McDavid WD, Waggener RG, Dennis MJ, Sank VJ, Payne WH (1977) Estimation of chemical composition and density from computed tomography carried out at a number of energies. Invest Radiol 12:189–194CrossRef

Millner MR, McDavid WD, Waggener RG, Dennis MJ, Payne WH, Sank VJ (1979) Extraction of information from CT scans at different energies. Med Phys 6:70–71CrossRef

Rutherford RA, Pullan BR, Isherwood I (1976) Measurement of effective atomic number and electron density using an EMI scanner. Neuroradiology 11:15–21CrossRef

Primak AN, Giraldo JCR, Eusemann CD et al (2010) Dual-source dual-energy CT with additional tin filtration: dose and image quality evaluation in phantoms and in-vivo. AJR Am J Roentgenol 195:1164CrossRef

Kelcz F, Joseph PM, Hilal SK (1979) Noise considerations in dual energy CT scanning. Med Phys 6:418–425CrossRef

Johnson TRC, Krauss B, Sedlmair M et al (2007) Material differentiation by dual energy CT: initial experience. Eur Radiol 17:1510–1517CrossRef

Pelgrim GJ, van Hamersvelt RW, Willemink MJ et al (2017) Accuracy of iodine quantification using dual energy CT in latest generation dual source and dual layer CT. Eur Radiol 27:3904–3912CrossRef

10.

Reimann AJ, Rinck D, Birinci-Aydogan A et al (2007) Dual-source computed tomography: Advances of improved temporal resolution in coronary plaque imaging. Invest Radiol 42:196–203CrossRef

11.

Yeh BM, Shepherd JA, Wang ZJ, Hui ST, Hartman RP, Prevrhal S (2009) Dual-energy and low-kVp CT in the abdomen. Am J Roentgenol:47–54

12.

Alvarez RE, Macovski A (1976) Energy-selective reconstructions in x-ray computerised tomography. Phys Med Biol 21:733CrossRef

13.

Coursey CA, Nelson RC, Boll DT et al (2010) Dual-energy multidetector CT: how does it work, what can it tell us, and when can we use it in abdominopelvic imaging? Radiographics 30:1037–1055CrossRef

14.

Yang C-B, Zhang S, Jia Y-J et al (2017) Dual energy spectral CT imaging for the evaluation of small hepatocellular carcinoma microvascular invasion. Eur J Radiol 95:222–227CrossRef

15.

Li Y, Shi G, Wang S, Wang S, Wu R (2013) Iodine quantification with dual-energy CT: phantom study and preliminary experience with VX2 residual tumour in rabbits after radiofrequency ablation. Br J Radiol 86:20130143CrossRef

16.

Primak AN, Fletcher JG, Vrtiska TJ et al (2007) Noninvasive differentiation of uric acid versus non--uric acid kidney stones using dual-energy CT. Acad Radiol 14:1441–1447CrossRef

17.

Graser A, Johnson TRC, Bader M et al (2008) Dual energy CT characterization of urinary calculi: initial in vitro and clinical experience. Invest Radiol 43:112–119CrossRef

18.

Fukuda T, Umezawa Y, Asahina A, Nakagawa H, Furuya K, Fukuda K (2017) Dual energy CT iodine map for delineating inflammation of inflammatory arthritis. Eur Radiol 27:5034–5040CrossRef

19.

Bongartz T, Glazebrook KN, Kavros SJ et al (2015) Dual-energy CT for the diagnosis of gout: an accuracy and diagnostic yield study. Ann Rheum Dis 74:1072–1077CrossRef

20.

Smits MLJ, Elschot M, van den Bosch MAAJ et al (2013) In Vivo Dosimetry Based on SPECT and MR Imaging of 166Ho-Microspheres for Treatment of Liver Malignancies. J Nucl Med 54:2093–2100CrossRef

21.

van Nimwegen SA, Bakker RC, Kirpensteijn J et al (2017) Intratumoral injection of radioactive holmium (166 Ho) microspheres for treatment of oral squamous cell carcinoma in cats. Vet Comp Oncol 16:114–124CrossRef

22.

Bakker RC, van Es RJJ, Rosenberg AJWP et al (2018) Intratumoral injection of radioactive holmium-166 microspheres in recurrent head and neck squamous cell carcinoma. Nucl Med Commun. https://doi.org/10.1097/mnm.0000000000000792:1

23.

Nijsen JFW, Cornelis Krijger G, van het Schip A (2007) The bright future of radionuclides for cancer therapy. Anticancer Agents Med Chem 7:271–290CrossRef

24.

Seevinck PR, Seppenwoolde J-H, de Wit TC et al (2007) Factors affecting the sensitivity and detection limits of MRI, CT, and SPECT for multimodal diagnostic and therapeutic agents. Anticancer Agents Med Chem 7:317–334CrossRef

25.

Seppenwoolde J-H, Nijsen JFW, Bartels LW, Zielhuis SW, van het Schip AD, Bakker CJG (2005) Internal radiation therapy of liver tumors: Qualitative and quantitative magnetic resonance imaging of the biodistribution of holmium-loaded microspheres in animal models. Magn Reson Med 53:76–84CrossRef

26.

van de Maat GH, Seevinck PR, Elschot M et al (2013) MRI-based biodistribution assessment of holmium-166 poly(L-lactic acid) microspheres after radioembolisation. Eur Radiol 23:827–835CrossRef

27.

Stierstorfer K, Rauscher A, Boese J, Bruder H, Schaller S, Flohr T (2004) Weighted FBP—a simple approximate 3D FBP algorithm for multislice spiral CT with good dose usage for arbitrary pitch. Phys Med Biol 49:2209CrossRef

28.

Nijsen JFW, Seppenwoolde J-H, Havenith T, Bos C, Bakker CJG, van het Schip AD (2004) Liver tumors: MR imaging of radioactive holmium microspheres—phantom and rabbit study. Radiology 231:491–499CrossRef

29.

Liu X, Yu L, Primak AN, McCollough CH (2009) Quantitative imaging of element composition and mass fraction using dual-energy CT: three-material decomposition. Med Phys 36:1602–1609CrossRef

30.

Siemens Healthineers Global (2017) SyngoCT Postprocessing applications - Instructions For Use - syngoCT Workplace syngo CT VB20

31.

Symons R, Cork TE, Lakshmanan MN et al (2017) Dual-contrast agent photon-counting computed tomography of the heart: initial experience. Int J Cardiovasc Imaging 33:1253–1261CrossRef

32.

Faby S, Maier J, Sawall S et al (2016) An efficient computational approach to model statistical correlations in photon counting x-ray detectors. Med Phys 43:3645–3960CrossRef

Title: Quantitative dual-energy CT material decomposition of holmium microspheres: local concentration determination evaluated in phantoms and a rabbit tumor model
Authors: Ralf Gutjahr
Robbert C. Bakker
Feiko Tiessens
Sebastiaan A. van Nimwegen
Bernhard Schmidt
Johannes Frank Wilhelmus Nijsen
Publication date: 01-01-2021
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 1/2021
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-020-07092-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Quantitative dual-energy CT material decomposition of holmium microspheres: local concentration determination evaluated in phantoms and a rabbit tumor model

Abstract

Objectives

Materials and methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

Key Points

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