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Open Access 01-03-2013 | Magnetic Resonance

MRI-based biodistribution assessment of holmium-166 poly(L-lactic acid) microspheres after radioembolisation

Authors: Gerrit H. van de Maat, Peter R. Seevinck, Mattijs Elschot, Maarten L. J. Smits, Hendrik de Leeuw, Alfred D. van het Schip, Maarten A. D. Vente, Bernard A. Zonnenberg, Hugo W. A. M. de Jong, Marnix G. E. H. Lam, Max A. Viergever, Maurice A. A. J. van den Bosch, Johannes F. W. Nijsen, Chris J. G. Bakker

Published in: European Radiology | Issue 3/2013

Abstract

Objectives

To demonstrate the feasibility of MRI-based assessment of the intrahepatic Ho-PLLA-MS biodistribution after radioembolisation in order to estimate the absorbed radiation dose.

Methods

Fifteen patients were treated with holmium-166 (¹⁶⁶Ho) poly(L-lactic acid)-loaded microspheres (Ho-PLLA-MS, mean 484 mg; range 408–593 mg) in a phase I study. Multi-echo gradient-echo MR images were acquired from which R ₂ ^* maps were constructed. The amount of Ho-PLLA-MS in the liver was determined by using the relaxivity r ₂ ^* of the Ho-PLLA-MS and compared with the administered amount. Quantitative single photon emission computed tomography (SPECT) was used for comparison with MRI regarding the whole liver absorbed radiation dose.

Results

R ₂ ^* maps visualised the deposition of Ho-PLLA-MS with great detail. The mean total amount of Ho-PLLA-MS detected in the liver based on MRI was 431 mg (range 236–666 mg) or 89 ± 19 % of the delivered amount (correlation coefficient r = 0.7; P < 0.01). A good correlation was found between the whole liver mean absorbed radiation dose as assessed by MRI and SPECT (correlation coefficient r = 0.927; P < 0.001).

Conclusion

MRI-based dosimetry for holmium-166 radioembolisation is feasible. Biodistribution is visualised with great detail and quantitative measurements are possible.

Key Points

• Radioembolisation is increasingly used for treating unresectable primary or metastatic liver tumours.

• MRI-based intrahepatic microsphere biodistribution assessment is feasible after holmium-166 radioembolisation.

• MRI enables quantification of holmium-166 microspheres in liver in a short imaging time.

• MRI can estimate the whole liver absorbed radiation dose following holmium-166 radioembolisation.

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Title: MRI-based biodistribution assessment of holmium-166 poly(L-lactic acid) microspheres after radioembolisation
Authors: Gerrit H. van de Maat
Peter R. Seevinck
Mattijs Elschot
Maarten L. J. Smits
Hendrik de Leeuw
Alfred D. van het Schip
Maarten A. D. Vente
Bernard A. Zonnenberg
Hugo W. A. M. de Jong
Marnix G. E. H. Lam
Max A. Viergever
Maurice A. A. J. van den Bosch
Johannes F. W. Nijsen
Chris J. G. Bakker
Publication date: 01-03-2013
Publisher: Springer-Verlag
Published in: European Radiology / Issue 3/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2648-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

MRI-based biodistribution assessment of holmium-166 poly(L-lactic acid) microspheres after radioembolisation

Abstract

Objectives

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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