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European Radiology
Published in: European Radiology 10/2019

Open Access 01-10-2019 | Osteoarthrosis | Musculoskeletal

T2 mapping of the meniscus is a biomarker for early osteoarthritis

Authors: Susanne M. Eijgenraam, Frans A. T. Bovendeert, Joost Verschueren, Jasper van Tiel, Yvonne M. Bastiaansen-Jenniskens, Marinus A. Wesdorp, Kazem Nasserinejad, Duncan E. Meuffels, Jamal Guenoun, Stefan Klein, Max Reijman, Edwin H. G. Oei

Published in: European Radiology | Issue 10/2019

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Abstract

Purpose

To evaluate in vivo T2 mapping as quantitative, imaging-based biomarker for meniscal degeneration in humans, by studying the correlation between T2 relaxation time and degree of histological degeneration as reference standard.

Methods

In this prospective validation study, 13 menisci from seven patients with radiographic knee osteoarthritis (median age 67 years, three males) were included. Menisci were obtained during total knee replacement surgery. All patients underwent pre-operative magnetic resonance imaging using a 3-T MR scanner which included a T2 mapping pulse sequence with multiple echoes. Histological analysis of the collected menisci was performed using the Pauli score, involving surface integrity, cellularity, matrix organization, and staining intensity. Mean T2 relaxation times were calculated in meniscal regions of interest corresponding with the areas scored histologically, using a multi-slice multi-echo postprocessing algorithm. Correlation between T2 mapping and histology was assessed using a generalized least squares model fit by maximum likelihood.

Results

The mean T2 relaxation time was 22.4 ± 2.7 ms (range 18.5–27). The median histological score was 10, IQR 7–11 (range 4–13). A strong correlation between T2 relaxation time and histological score was found (rs = 0.84, CI 95% 0.64–0.93).

Conclusion

In vivo T2 mapping of the human meniscus correlates strongly with histological degeneration, suggesting that T2 mapping enables the detection and quantification of early compositional changes of the meniscus in knee OA.

Key Points

• Prospective histology-based study showed that in vivo T 2 mapping of the human meniscus correlates strongly with histological degeneration.
• Meniscal T 2 mapping allows detection and quantifying of compositional changes, without need for contrast or special MRI hardware.
• Meniscal T 2 mapping provides a biomarker for early OA, potentially allowing early treatment strategies and prevention of OA progression.
Appendix
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Metadata
Title
T2 mapping of the meniscus is a biomarker for early osteoarthritis
Authors
Susanne M. Eijgenraam
Frans A. T. Bovendeert
Joost Verschueren
Jasper van Tiel
Yvonne M. Bastiaansen-Jenniskens
Marinus A. Wesdorp
Kazem Nasserinejad
Duncan E. Meuffels
Jamal Guenoun
Stefan Klein
Max Reijman
Edwin H. G. Oei
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 10/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06091-1

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