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European Radiology

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01-11-2017 | Neuro

Retrosplenial cortical thinning as a possible major contributor for cognitive impairment in HIV patients

Authors: Na-Young Shin, Jinwoo Hong, Jun Yong Choi, Seung-Koo Lee, Soo Mee Lim, Uicheul Yoon

Published in: European Radiology | Issue 11/2017

Abstract

Objectives

To identify brain cortical regions relevant to HIV-associated neurocognitive disorder (HAND) in HIV patients.

Methods

HIV patients with HAND (n = 10), those with intact cognition (HIV-IC; n = 12), and age-matched, seronegative controls (n = 11) were recruited. All participants were male and underwent 3-dimensional T1-weighted imaging. Both vertex-wise and region of interest (ROI) analyses were performed to analyse cortical thickness.

Results

Compared to controls, both HIV-IC and HAND showed decreased cortical thickness mainly in the bilateral primary sensorimotor areas, extending to the prefrontal and parietal cortices. When directly comparing HIV-IC and HAND, HAND showed cortical thinning in the left retrosplenial cortex, left dorsolateral prefrontal cortex, left inferior parietal lobule, bilateral superior medial prefrontal cortices, right temporoparietal junction and left hippocampus, and cortical thickening in the left middle occipital cortex. Left retrosplenial cortical thinning showed significant correlation with slower information processing, declined verbal memory and executive function, and impaired fine motor skills.

Conclusions

This study supports previous research suggesting the selective vulnerability of the primary sensorimotor cortices and associations between cortical thinning in the prefrontal and parietal cortices and cognitive impairment in HIV-infected patients. Furthermore, for the first time, we propose retrosplenial cortical thinning as a possible major contributor to HIV-associated cognitive impairment.

Key points

• Primary sensorimotor and supplementary motor cortices were selectively vulnerable to HIV infection

• Prefrontal and parietal cortical thinning was associated with HIV-associated cognitive impairment

• Retrosplenial cortical thinning might be a major contributor to HIV-associated cognitive impairment

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Title: Retrosplenial cortical thinning as a possible major contributor for cognitive impairment in HIV patients
Authors: Na-Young Shin
Jinwoo Hong
Jun Yong Choi
Seung-Koo Lee
Soo Mee Lim
Uicheul Yoon
Publication date: 01-11-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 11/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-4836-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Retrosplenial cortical thinning as a possible major contributor for cognitive impairment in HIV patients

Abstract

Objectives

Methods

Results

Conclusions

Key points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key points

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