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European Radiology

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01-11-2016 | Breast

Intravoxel incoherent motion MR imaging for breast lesions: comparison and correlation with pharmacokinetic evaluation from dynamic contrast-enhanced MR imaging

Authors: Chunling Liu, Kun Wang, Queenie Chan, Zaiyi Liu, Jine Zhang, Hui He, Shuixing Zhang, Changhong Liang

Published in: European Radiology | Issue 11/2016

Abstract

Objectives

To compare diagnostic performance for breast lesions by quantitative parameters derived from intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and to explore whether correlations exist between these parameters.

Methods

IVIM and DCE MRI were performed on a 1.5-T MRI scanner in patients with suspicious breast lesions. Thirty-six breast cancers and 23 benign lesions were included in the study. Quantitative parameters from IVIM (D, f and D*) and DCE MRI (K^trans, K_ep, V_e and V_p) were calculated and compared between malignant and benign lesions. Spearman correlation test was used to evaluate correlations between them.

Results

D, f, D* from IVIM and K^trans, K_ep, V_p from DCE MRI were statistically different between breast cancers and benign lesions (p < 0.05, respectively) and D demonstrated the largest area under the receiver-operating characteristic curve (AUC = 0.917) and had the highest specificity (83 %). The f value was moderately statistically correlated with V_p (r = 0.692) and had a poor correlation with K^trans (r = 0.456).

Conclusions

IVIM MRI is useful in the differentiation of breast lesions. Significant correlations were found between perfusion-related parameters from IVIM and DCE MRI. IVIM may be a useful adjunctive tool to standard MRI in diagnosing breast cancer.

Key Points

• IVIM provided diffusion as well as perfusion information

• IVIM could help differential diagnosis of breast lesions

• Correlations were found between perfusion-related parameters from IVIM and DCE MRI

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Title: Intravoxel incoherent motion MR imaging for breast lesions: comparison and correlation with pharmacokinetic evaluation from dynamic contrast-enhanced MR imaging
Authors: Chunling Liu
Kun Wang
Queenie Chan
Zaiyi Liu
Jine Zhang
Hui He
Shuixing Zhang
Changhong Liang
Publication date: 01-11-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 11/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4241-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intravoxel incoherent motion MR imaging for breast lesions: comparison and correlation with pharmacokinetic evaluation from dynamic contrast-enhanced MR imaging

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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