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European Radiology

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01-05-2014 | Breast

Is there any correlation between model-based perfusion parameters and model-free parameters of time-signal intensity curve on dynamic contrast enhanced MRI in breast cancer patients?

Authors: Boram Yi, Doo Kyoung Kang, Dukyong Yoon, Yong Sik Jung, Ku Sang Kim, Hyunee Yim, Tae Hee Kim

Published in: European Radiology | Issue 5/2014

Abstract

Objective

To find out any correlation between dynamic contrast-enhanced (DCE) model-based parameters and model-free parameters, and evaluate correlations between perfusion parameters with histologic prognostic factors.

Methods

Model-based parameters (Ktrans, Kep and Ve) of 102 invasive ductal carcinomas were obtained using DCE-MRI and post-processing software. Correlations between model-based and model-free parameters and between perfusion parameters and histologic prognostic factors were analysed.

Results

Mean Kep was significantly higher in cancers showing initial rapid enhancement (P = 0.002) and a delayed washout pattern (P = 0.001). Ve was significantly lower in cancers showing a delayed washout pattern (P = 0.015). Kep significantly correlated with time to peak enhancement (TTP) (ρ = −0.33, P < 0.001) and washout slope (ρ = 0.39, P = 0.002). Ve was significantly correlated with TTP (ρ = 0.33, P = 0.002). Mean Kep was higher in tumours with high nuclear grade (P = 0.017). Mean Ve was lower in tumours with high histologic grade (P = 0.005) and in tumours with negative oestrogen receptor status (P = 0.047). TTP was shorter in tumours with negative oestrogen receptor status (P = 0.037).

Conclusions

We could acquire general information about the tumour vascular physiology, interstitial space volume and pathologic prognostic factors by analyzing time-signal intensity curve without a complicated acquisition process for the model-based parameters.

Key points

• Kep mainly affected the initial and delayed curve pattern in time–signal intensity curve.

• There is significant correlation between model-based and model-free parameters.

• We acquired information about tumour vascular physiology, interstitial space volume and prognostic factors.

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Title: Is there any correlation between model-based perfusion parameters and model-free parameters of time-signal intensity curve on dynamic contrast enhanced MRI in breast cancer patients?
Authors: Boram Yi
Doo Kyoung Kang
Dukyong Yoon
Yong Sik Jung
Ku Sang Kim
Hyunee Yim
Tae Hee Kim
Publication date: 01-05-2014
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 5/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3100-6

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Springer Medicine

Is there any correlation between model-based perfusion parameters and model-free parameters of time-signal intensity curve on dynamic contrast enhanced MRI in breast cancer patients?

Abstract

Objective

Methods

Results

Conclusions

Key points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

Key points

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