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01-08-2021 | Arthritis | Review

Expanding the spectrum of reactive arthritis (ReA): classic ReA and infection-related arthritis including poststreptococcal ReA, Poncet’s disease, and iBCG-induced ReA

Authors: Yoshinori Taniguchi, Hirofumi Nishikawa, Takeshi Yoshida, Yoshio Terada, Kurisu Tada, Naoto Tamura, Shigeto Kobayashi

Published in: Rheumatology International | Issue 8/2021

Abstract

Reactive arthritis (ReA) is a form of sterile arthritis that occurs secondary to an extra-articular infection in genetically predisposed individuals. The extra-articular infection is typically an infection of the gastrointestinal tract or genitourinary tract. Infection-related arthritis is a sterile arthritis associated with streptococcal tonsillitis, extra-articular tuberculosis, or intravesical instillation of bacillus Calmette–Guérin (iBCG) therapy for bladder cancer. These infection-related arthritis diagnoses are often grouped with ReA based on the pathogenic mechanism. However, the unique characteristics of these entities may be masked by a group classification. Therefore, we reviewed the clinical characteristics of classic ReA, poststreptococcal ReA, Poncet’s disease, and iBCG-induced ReA. Considering the diversity in triggering microbes, infection sites, and frequency of HLA-B27, these are different disorders. However, the clinical symptoms and intracellular parasitism pathogenic mechanism among classic ReA and infection-related arthritis entities are similar. Therefore, poststreptococcal ReA, Poncet’s disease, and iBCG-induced ReA could be included in the expanding spectrum of ReA, especially based on the pathogenic mechanism.

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Title: Expanding the spectrum of reactive arthritis (ReA): classic ReA and infection-related arthritis including poststreptococcal ReA, Poncet’s disease, and iBCG-induced ReA
Authors: Yoshinori Taniguchi
Hirofumi Nishikawa
Takeshi Yoshida
Yoshio Terada
Kurisu Tada
Naoto Tamura
Shigeto Kobayashi
Publication date: 01-08-2021
Publisher: Springer Berlin Heidelberg
Keywords: Arthritis
Reactive Arthritis
Spondyloarthropathy
Published in: Rheumatology International / Issue 8/2021
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-021-04879-3

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