Published in:
01-07-2010 | Short Communication
Association of cytosine–adenine repeat polymorphism of the estrogen receptor-β gene with rheumatoid arthritis symptoms
Authors:
A. González-Canga, K. Ugai, M. Suzuki, H. Okuzawa, E. Negishi, K. Ueno
Published in:
Rheumatology International
|
Issue 9/2010
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Abstract
The influence of the polymorphism of the estrogen receptor-β gene, cytosine–adenine (CA) dinucleotide repeat in intron 6, in the occurrence of rheumatoid arthritis (RA) was investigated. Forty-seven RA patients and 36 control subjects with osteoarthritis (OA) were recruited. CA repeat polymorphism was examined using denaturing high-performance liquid chromatography (WAVE® DNA Fragment Analysis System). The mean number of CA repeats was significantly higher in RA than in OA patients. Two groups were established: ≤21 repeats (short S), ≥22 repeats (long L); and 3 kinds of genotypes (SS, SL, LL) were found. In RA patients, the L allele frequency was higher (OR = 2.03; P ≤ 0.05 Fisher’s test) and more subjects carried the LL genotype (OR = 5.50; P ≤ 0.05 Fisher’s test) compared to OA patients. It was concluded that the presence of the L allele could be a risk factor for RA, although additional larger scale study is needed.