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Rheumatology International
Published in: Rheumatology International 3/2005

01-04-2005 | Review Article

Evidence-based use of methotrexate in children with rheumatic diseases: a consensus statement of the Working Groups Pediatric Rheumatology Germany (AGKJR) and Pediatric Rheumatology Austria

Authors: Tim Niehues, Gerd Horneff, Hartmut Michels, Michaela Sailer Höck, Lothar Schuchmann

Published in: Rheumatology International | Issue 3/2005

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Abstract

Juvenile idiopathic arthritis (JIA) is the most common diagnosis in children and adolescents with rheumatic disorders. In many children and adolescents, JIA is successfully treated with non-steroidal anti-inflammatory drugs (NSAID) and physiotherapy. However, in a significant number of cases the disease is resistant to this therapy, and treatment with “second line” disease-modifying antirheumatic drugs (DMARDs) is required. Methotrexate (MTX) is frequently referred to as “first-choice second-line agent” for the treatment of JIA. To increase drug safety, the Working Groups for Children and Adolescents with Rheumatic Diseases in Germany (AGKJR) and Pediatric Rheumatology Austria have initiated the formulation of evidence-based recommendations. Evidence is based on consensus expert meetings, a MEDLINE search with the key words “Methotrexate” and “juvenile arthritis” limited to age 0–18 years, standard textbooks and review articles, data from the central registry of the German Research Center for Rheumatic Diseases (Deutsches Rheumaforschungszentrum Berlin DRFZ), experience with MTX in adults with rheumatoid arthritis (RA), and recommendations of the German Society of Rheumatology (DGRh). Based on these data, evidence and recommendations are graded, and evidence-based recommendations for the use of MTX in children and adolescents with rheumatic disease are presented.
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Metadata
Title
Evidence-based use of methotrexate in children with rheumatic diseases: a consensus statement of the Working Groups Pediatric Rheumatology Germany (AGKJR) and Pediatric Rheumatology Austria
Authors
Tim Niehues
Gerd Horneff
Hartmut Michels
Michaela Sailer Höck
Lothar Schuchmann
Publication date
01-04-2005
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 3/2005
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-004-0537-y

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