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Seminars in Immunopathology
Published in: Seminars in Immunopathology 5/2020

01-10-2020 | Review

Immunosenescence is both functional/adaptive and dysfunctional/maladaptive

Authors: T. Fulop, A. Larbi, K. Hirokawa, A. A. Cohen, J. M. Witkowski

Published in: Seminars in Immunopathology | Issue 5/2020

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Abstract

Alterations in the immune system with aging are considered to underlie many age-related diseases. However, many elderly individuals remain healthy until even a very advanced age. There is also an increase in numbers of centenarians and their apparent fitness. We should therefore change our unilaterally detrimental consideration of age-related immune changes. Recent data taking into consideration the immunobiography concept may allow for meaningful distinctions among various aging trajectories. This implies that the aging immune system has a homeodynamic characteristic balanced between adaptive and maladaptive aspects. The survival and health of an individual depends from the equilibrium of this balance. In this article, we highlight which parts of the aging of the immune system may be considered adaptive in contrast to those that may be maladaptive.
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Metadata
Title
Immunosenescence is both functional/adaptive and dysfunctional/maladaptive
Authors
T. Fulop
A. Larbi
K. Hirokawa
A. A. Cohen
J. M. Witkowski
Publication date
01-10-2020
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 5/2020
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-020-00818-9

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